Polysaccharides Chiral Stationary Phases in Liquid Chromatography

Chirality of organophosphorus pesticides: Analysis and toxicity

“…The advantage of using enantioselective HPLC methods is that individual enantiomers could be recovered following the separation, and subsequently used in toxicological experiments that require separated stereoisomers. In addition, due to the strongly polar nature and low volatility of most OPs, enantiomeric resolution of chiral OPs is often best achieved by enantioselective HPLC [57][58][59].…”

Hybrid monolithic columns coated with cellulose tris(3,5-dimethylphenyl-carbamate) for enantioseparations in capillary electrochromatography and capillary liquid chromatography

“…Polysaccharide derivatives have occupied a unique place among these chiral stationary phases (CSPs) and have been the most widely used chiral selector for enantioseparation of a broad range of chiral compounds [21][22][23][24]. Several kinds of polysaccharide derivatives such as cellulose tris(3,5-dimethylphenylcarbamate) (CDMPC), cellulose tris(4-methylbenzoate), cellulose tris(3,5-dichlorophenyl carbamate) and amylose tris(3,5-dimethylphenylcarbamate) have been coated or immobilized onto the silica-based monoliths and successfully applied for enantioseparations in CLC or CEC [25,26,27,28,29].…”

Enantiomeric separation of organophosphorus pesticides by high-performance liquid chromatography, gas chromatography and capillary electrophoresis and their applications to environmental fate and toxicity assays

“…Recently, HPLC has become useful not only for determining the optical purity of enantiomers but also for preparing enantiopure standards. So far, more than 100 CSPs have been sold commercially [14], and approximately 99% of enantiomeric separations were carried out by HPLC on various CSPs [15]. Based on their different chemical structures, CSPs can be divided into at least seven classes, including Pirkle's type, polysaccharides, cyclodextrins, macrocyclic glycopeptide antibiotics, proteins, crown ethers and ligand exchangers.…”