Polysaccharides from tubers of Bletilla striata: Physicochemical characterization, formulation of buccoadhesive wafers and preliminary study on treating oral ulcer

Liao, Zhencheng; Zeng, Rui; Hu, Lingli; Maffucci, Katherine G.; Qu, Yan

doi:10.1016/j.ijbiomac.2018.09.050

Cited by 77 publications

(34 citation statements)

References 46 publications

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“…Bletilla striata polysaccharide (BSP) is a water-soluble polysaccharide extracted from the plant Bletilla striata and it is a polymer consisting of several 1,4-chain mannitol residues and 1,4-chain glucose residues [11, 12]. The BSP has good pharmacological activities, such as promoting wound healing, antibacterial, antitumor, antifibrotic, and so on [13, 14].…”

Section: Introductionmentioning

confidence: 99%

“…Simultaneously, the BSP has great potential and application prospects in biological delivery systems, wound dressings, and other biomaterials because of its great biodegradability and biocompatibility [15–17]. In our previous study, the BSP has been found to play a nontrivial role in promoting oral ulcer healing as a component in buccoadhesive wafers [11]. Nevertheless, the promoting wound healing effect of the BSP on dermal wound injury and its related mechanisms remain largely unclear.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Polysaccharides from Bletilla striata on the Healing of Dermal Wounds in Mice

Zhang

Chen

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Bletilla striata has been largely used in traditional folk medicine in China as a wound healing agent and to treat gastritis and several other health problems. Some studies have shown that plant polysaccharides may have the ability to promote wound healing. The aim of this work was to evaluate the wound healing activity of the polysaccharide extracted from Bletilla striata. Firstly, a Bletilla striata polysaccharide was extracted by water extraction and alcohol precipitation and characterized by Fourier transform infrared spectroscopy. The Bletilla striata polysaccharide was then tested for cell migration and proliferation using the mouse fibroblast cell line. Then, the Bletilla striata hydrogel was fabricated for acute wound health care of the mouse full-thickness excision. The results showed that the BSP enhanced the proliferation and migration of L929 cells. The superior wound healing capacity of the BSP hydrogel was demonstrated that it significantly accelerated the wound healing process in vivo in full-thickness skin defect wounded models. Compared to the saline group, the BSP hydrogel could accelerate wound healing and promote re-epithelialization and collagen deposition by means of TGF-β/Smad signal pathway activation. Taken together, BSP hydrogel would be a useful pharmaceutic candidate for acute cutaneous wound health care.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of Polysaccharides from Bletilla striata on the Healing of Dermal Wounds in Mice

Zhang

Chen

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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“…The various doses were delivered by adjusting the different irradiation time at a fixed rate. [ 36 ] The irradiation parameters were as follows: 40keY energy, 1.4 S mm aluminum filter, and 40 mA current. A side of gingivitis was irradiated on ice in a custom‐made icebox, [ 37 the automated gingival models' assay was performed as described.…”

Section: Methodsmentioning

confidence: 99%

Bletilla striata Polysaccharides Improve Hemostatic, Antiinflammatory Efficacy, and Platelet Aggregation in Gingivitis Rat Model

Guo

Bao

et al. 2020

Starch Stärke

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In this study, the bioactivity of the Bletilla striata polysaccharides (BSPS) on platelet aggregation and anti‐inflammation is investigated. For this purpose, a physiological system in vitro is established to evaluate the hemostatic effect of BSPS by measuring the platelet aggregation (PAG) rate, cyclic adenosine monophosphate (cAMP), and thromboxane B2 (TXB2). A quantifiable inflammatory model of human gingival epithelial cells (HGECs) is established by inducing lipopolysaccharide (LPS) to evaluate the anti‐inflammatory effect of BSPS. An experimental gingivitis rat model in vivo is set up to further verify hemostatic and anti‐inflammatory efficacy of BSPS, which is comprehensively evaluated through the following five techniques: X‐ray morphological observation, hematoxylin‐eosin (HE) staining analysis, probe index (plaque index, gingival index, bleeding on probing) diagnostic evaluation, immunoglobulin (IgA, IgM, IgG), and cytokines. Interestingly, the changes of cytokines in vivo are in accordance with those in vitro. The positive effects of BSPS in hemostasis and anti‐inflammation are also confirmed by X‐ray observation and HE staining. The above results demonstrate that BSPS promotes platelet aggregation with an anti‐inflammatory effect, which suggests that the BSPS may be beneficial in the treatment of hemostasis and inflammatory diseases.

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“…There are polysaccharides with various monosaccharide constituents and chemical structures isolated from B. striata. Meanwhile, the monosaccharide constituents and basic chemical structures of BSPs have been determined by several research groups through infrared spectroscopy (IR), nuclear magnetic resonance (NMR), gas chromatography-mass spectroscopy (GC-MS), gas chromatography (GC), high-performance liquid chromatography (HPLC), acid hydrolysis, methylation analysis, periodate oxidation, and Smith's degradation [7,9,18,35]. The primary structural characteristics of BSPs and also their biological activities are summarized in Table 2, together with their related bibliographies.…”

Section: Physiochemical and Structural Featuresmentioning

confidence: 99%

“…Increasing numbers of modern chemical and pharmacological studies revealed that B. striata has many beneficial effects, including healing, hemostasis, antioxidation, antiinflammation, antifibrotic, and immunomodulatory activity in vitro [4,7,8]. These multiple pharmacological effects of B. striata are attributed to its various functional ingredients, such as polysaccharides, saponins, flavonoids, terpenoids, trace elements, and other chemicals [1,4], among which the polysaccharides (BSPs) have gradually received attention and are now considered to be the main active substance of B. striata for its beneficial effects [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

A Review of Isolation, Chemical Properties, and Bioactivities of Polysaccharides from Bletilla striata

Yin

Nie

et al. 2020

BioMed Research International

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Recently, polysaccharides from Bletilla striata, a member of the orchidaceous family, aroused the wide interest of people, especially their isolation, chemical properties, and bioactivities. It is reported that these polysaccharides are the most important biologically active components of B. striata, exhibiting various biological activities, such as immunomodulatory, antioxidant, antifibrotic, and hemostatic effects. This review appraised the available literatures which described different aspects of B. striata polysaccharides, including the extraction, separation, purification, structural characterization, and biological activities. We expect to lay the foundation for further investigation of the application of B. striata polysaccharides in the field of functional foods and biomedicine.

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Polysaccharides from tubers of Bletilla striata: Physicochemical characterization, formulation of buccoadhesive wafers and preliminary study on treating oral ulcer

Cited by 77 publications

References 46 publications

Effect of Polysaccharides from Bletilla striata on the Healing of Dermal Wounds in Mice

Effect of Polysaccharides from Bletilla striata on the Healing of Dermal Wounds in Mice

Bletilla striata Polysaccharides Improve Hemostatic, Antiinflammatory Efficacy, and Platelet Aggregation in Gingivitis Rat Model

A Review of Isolation, Chemical Properties, and Bioactivities of Polysaccharides from Bletilla striata

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