Polystyrene Nanoparticles Activate Erythrocyte Aggregation and Adhesion to Endothelial Cells

Barshtein, Gregory; Livshits, Leonid; Shvartsman, L. D.; Shlomai, Noa Ofek; Yedgar, Saul; Arbell, Dan

doi:10.1007/s12013-015-0705-6

Cited by 53 publications

(22 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Earlier, it was demonstrated that relatively large NP agglomerates (~0.2 μm) were able to penetrate RBCs through the membrane with no influence on the nature of the NP material 7 . Significant RBC agglutination and stronger adhesion caused by small NPs than larger ones were observed for different types of NPs 8–10 . Surface properties are considered one of the major factors for the hemocompatibility of NPs.…”

Section: Introductionmentioning

confidence: 96%

Mutual interaction of red blood cells influenced by nanoparticles

Avsievich

Попов

Bykov

et al. 2019

Sci Rep

View full text Add to dashboard Cite

Despite extensive studies on different types of nanoparticles as potential drug carriers, the application of red blood cells (RBCs) as natural transport agents for systemic drug delivery is considered a new paradigm in modern medicine and possesses great potential. There is a lack of studies on the influence of drug carriers of different compositions on RBCs, especially regarding their potential impact on human health. Here, we apply conventional microscopy to observe the formation of RBC aggregates and optical tweezers to quantitatively assess the mutual interaction of RBCs incubated with inorganic and polymeric nanoparticles. Scanning electron microscopy is utilized for direct observation of nanoparticle localization on RBC membranes. The experiments are performed in a platelet-free blood plasma mimicking the RBC natural environment. We show that nanodiamonds influence mutual RBC interactions more antagonistically than other nanoparticles, resulting in higher aggregation forces and the formation of larger cell aggregates. In contrast, polymeric particles do not cause anomalous RBC aggregation. The results emphasize the application of optical tweezers for the direct quantitative assessment of the mutual interaction of RBCs influenced by nanomaterials.

show abstract

Section: Introductionmentioning

confidence: 96%

Mutual interaction of red blood cells influenced by nanoparticles

Avsievich

Попов

Bykov

et al. 2019

Sci Rep

View full text Add to dashboard Cite

show abstract

“…The authors showed that the formation of RBC aggregates increased with decreasing particle size and in parallel a distinctly elevated adhesion to endothelial cells was observed. 175 In addition, Barbul et al showed that polystyrene particles with sizes of 27, 45, and 100 nm adsorbed to RBCs led to shape transformations and reduced cell deformability, with the 27 nm particles showing the strongest effect. 176 Furthermore, Xia et al showed the influence of 30 nm polystyrene nanoparticles on the endocytotic pathway in macrophages and human cancer cell lines A549, HePG-2, and HCT116.…”

Section: Impact Of Nanoplastics On Human Healthmentioning

confidence: 99%

Emergence of Nanoplastic in the Environment and Possible Impact on Human Health

Lehner

Weder

Petri‐Fink

et al. 2019

Environ. Sci. Technol.

901

364

View full text Add to dashboard Cite

On account of environmental concerns, the fate and adverse effects of plastics have attracted considerable interest in the past few years. Recent studies have indicated the potential for fragmentation of plastic materials into nanoparticles, i.e., "nanoplastics," and their possible accumulation in the environment. Nanoparticles can show markedly different chemical and physical properties than their bulk material form. Therefore possible risks and hazards to the environment need to be considered and addressed. However, the fate and effect of nanoplastics in the (aquatic) environment has so far been little explored. In this review, we aim to provide an overview of the literature on this emerging topic, with an emphasis on the reported impacts of nanoplastics on human health, including the challenges involved in detecting plastics in a biological environment. We first discuss the possible sources of nanoplastics and their fates and effects in the environment and then describe the possible entry routes of these particles into the human body, as well as their uptake mechanisms at the cellular level. Since the potential risks of environmental nanoplastics to humans have not yet been extensively studied, we focus on studies demonstrating cell responses induced by polystyrene nanoparticles. In particular, the influence of particle size and surface chemistry are discussed, in order to understand the possible risks of nanoplastics for humans and provide recommendations for future studies.

show abstract

“…The presence of this defense system could explain their resistance to the damage induced by nanoparticles, indicating that these cells are not as sensitive to the toxic effects of nanoparticles. However, one of the factors that can influence whether a nanoparticle leads to hemolysis or not is the presence of surfactants [28] and [29] coatings. Surfactants confer different properties to nanomaterials, altering charge, interfacial tension, and becoming an amphiphilic molecule, which reduces the nanomaterial coalescence.…”

Section: Interaction Of Nanomaterials With Red Cellsmentioning

confidence: 99%

Interaction of Nanoparticles with Blood Components and Associated Pathophysiological Effects

Cruz¹,

Rodríguez-Fragoso²,

JorgeReyes-Esparza³

et al. 2018

Unraveling the Safety Profile of Nanoscale Particles and Materials - From Biomedical to Environmental Applications

View full text Add to dashboard Cite

Nanotechnology currently plays a pivotal role in several fields and has enabled substantial advances in a relatively short time. In biomedicine, nanomaterials can be potentially employed as a tool for early diagnosis and an innovative mode of drug delivery. Novel nanomaterials are currently widely manipulated without a full assessment of their potential health risks. It is commonly thought that nanomaterials' first contact with the organism is through the different components of the immune system. However, if the entry route is intravenous, the first contact will be with the blood's components (erythrocytes, platelets, white cells, plasma and complement proteins). The presence of nanomaterials within a dynamic environment such as the bloodstream can produce potential harmful effects following interaction with several blood components. The design of innovative strategies leading to the development of more hemocompatible nanomaterials is also necessary.

show abstract

Polystyrene Nanoparticles Activate Erythrocyte Aggregation and Adhesion to Endothelial Cells

Cited by 53 publications

References 55 publications

Mutual interaction of red blood cells influenced by nanoparticles

Mutual interaction of red blood cells influenced by nanoparticles

Emergence of Nanoplastic in the Environment and Possible Impact on Human Health

Interaction of Nanoparticles with Blood Components and Associated Pathophysiological Effects

Contact Info

Product

Resources

About