Polyurethane Modified with Plasma-Ion Implantation for Medical Applications

Chudinov, V. S.; Kondyurina, Irina; Шардаков, И. Н.; Свистков, А. Л.; Осоргина, И. В.; Kondyurin, Alexey

doi:10.1134/s0006350918030053

Cited by 12 publications

(3 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The endothelial cells also grow well on the PIII-treated polyurethane surface. However, the untreated polyurethane is observed totally covered with endothelial cells after only 6 days, while the PIII-treated polyurethane is totally covered after 2 days, as observed on the control tissue culture plastic (TCP) [ 53 ].…”

Section: Discussionmentioning

confidence: 99%

Foreign Body Reaction (Immune Response) for Artificial Implants Can Be Avoided: An Example of Polyurethane in Mice for 1 Week

Kondyurina,

Kondyurin

2023

JFB

View full text Add to dashboard Cite

Despite great success with artificial implants for the human body, modern implants cannot solve major health problems. The reason is an immune reaction of organisms to artificial implants, known as the foreign body reaction. We have found a way to avoid or decrease the foreign body reaction. The surface of an artificial implant is modified with condensed aromatic structures containing free radicals, which provide a covalent attachment of host proteins in a native conformation. The total protein coverage prevents the direct contact of immune cells with the implant surface, and the immune cells are not activated. As a result, the immune response of the organism is not generated, and the artificial implant is not isolated from the tissue; there is no collagen capsule, low activity of macrophages, low cell proliferation, and low inflammatory activity.

show abstract

Section: Discussionmentioning

confidence: 99%

Foreign Body Reaction (Immune Response) for Artificial Implants Can Be Avoided: An Example of Polyurethane in Mice for 1 Week

Kondyurina,

Kondyurin

2023

JFB

View full text Add to dashboard Cite

show abstract

“…Для изменения свойств поверхности поливинилхлорида с целью улучшения его биосовместимости мы будем использовать метод плазменно-иммерсионной ионной имплантации [10][11]. С помощью данного метода воздействия высокоэнергетических ионов на полимерный материал на его поверхности формируется карбонизованный слой, содержащий полиароматические конденсированные структуры с неспаренными электронами, стабилизированными π-электронным облаком на границах графитоподобных кластеров [12][13][14]. Поверхность карбонизованного слоя характеризуется улучшенной смачиваемостью и адсорбционной активностью к белкам [15].…”

Section: для цитированияunclassified

Covalent immobilization of albumin on the surface of medical polyvinyl chloride modified by plasma-imersion ion implantation

Kondyurina,

McKenzie

2023

Perm Sci. Cent. J.

View full text Add to dashboard Cite

“…As a result of ion-plasma treatment, carbonization of the surface layer of the polymer occurs and a carbonized hydrophilic nanolayer is formed that is capable of covalently binding adsorbed proteins in the native conformation. This nanolayer has improved biocompatibility compared to the polymer substrate [ 14 , 15 , 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Mechanical Properties of the Carbonized Layer Formed by Ion Flow Orientated at Different Angles to the Polyurethane Surface

Chudinov,

Shardakov,

Ivanov

et al. 2023

Polymers

View full text Add to dashboard Cite

Polymer materials are widely used in medicine due to their mechanical properties and biological inertness. When ion-plasma treatment is used on a polymer material, a carbonization process occurs in the surface nanolayer of the polymer sample. As a result, a surface carbonized nanolayer is formed, which has mechanical properties different from those of the substrate. This layer has good biocompatibility. The formation of a carbonized nanolayer on the surface of polymer implants makes it possible to reduce the body’s reaction to a foreign body. Typically, to study the properties of a carbonized layer, flat polymer samples are used, which are treated with an ion flow perpendicular to the surface. But medical endoprostheses often have a curved surface, so ion-plasma treatment can occur at different angles to the surface. This paper presents the results of a study of the morphological and mechanical properties of a carbonized layer formed on a polyurethane surface. The dependence of these properties on the directional angle of the ion flow and its fluence has been established. To study the surface morphology and elastic properties, methods of atomic force microscopy and methods of elasticity theory were used. The strength properties of the carbonized layer were studied using a stretching device combined with a digital optical microscope.

show abstract

Polyurethane Modified with Plasma-Ion Implantation for Medical Applications

Cited by 12 publications

References 29 publications

Foreign Body Reaction (Immune Response) for Artificial Implants Can Be Avoided: An Example of Polyurethane in Mice for 1 Week

Foreign Body Reaction (Immune Response) for Artificial Implants Can Be Avoided: An Example of Polyurethane in Mice for 1 Week

Covalent immobilization of albumin on the surface of medical polyvinyl chloride modified by plasma-imersion ion implantation

Mechanical Properties of the Carbonized Layer Formed by Ion Flow Orientated at Different Angles to the Polyurethane Surface

Contact Info

Product

Resources

About