Polyvinyl acetate-based film coatings

Kolter, Karl; Dashevsky, Andrei; Irfan, Muhamad; Bodmeier, Roland

doi:10.1016/j.ijpharm.2013.08.077

Cited by 47 publications

(11 citation statements)

References 19 publications

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“…This was suggested to be due to media absorbing the PVAc, which transformed the dry and stiff PVAc matrix into a soft and flexible matrix. Due to this plasticising property PVAc has been widely investigated for extended drug release applications [ 49 ]. Whilst application of the PVAc to the PLA fibres strongly influenced the compressive strength of the dry scaffolds, the addition of β-TCP (up to 30 wt %) in the PVAc coating only imparted a small effect on the compressive strength of the samples after immersion in PBS at 37 °C over the 10 day period.…”

Section: Discussionmentioning

confidence: 99%

Tubular Scaffold with Shape Recovery Effect for Cell Guide Applications

Hossain

Zhu

Felfel

et al. 2015

JFB

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Tubular scaffolds with aligned polylactic acid (PLA) fibres were fabricated for cell guide applications by immersing rolled PLA fibre mats into a polyvinyl acetate (PVAc) solution to bind the mats. The PVAc solution was also mixed with up to 30 wt % β-tricalcium phosphate (β-TCP) content. Cross-sectional images of the scaffold materials obtained via scanning electron microscopy (SEM) revealed the aligned fibre morphology along with a significant number of voids in between the bundles of fibres. The addition of β-TCP into the scaffolds played an important role in increasing the void content from 17.1% to 25.3% for the 30 wt % β-TCP loading, which was measured via micro-CT (µCT) analysis. Furthermore, µCT analyses revealed the distribution of aggregated β-TCP particles in between the various PLA fibre layers of the scaffold. The compressive modulus properties of the scaffolds increased from 66 MPa to 83 MPa and the compressive strength properties decreased from 67 MPa to 41 MPa for the 30 wt % β-TCP content scaffold. The scaffolds produced were observed to change into a soft and flexible form which demonstrated shape recovery properties after immersion in phosphate buffered saline (PBS) media at 37 °C for 24 h. The cytocompatibility studies (using MG-63 human osteosarcoma cell line) revealed preferential cell proliferation along the longitudinal direction of the fibres as compared to the control tissue culture plastic. The manufacturing process highlighted above reveals a simple process for inducing controlled cell alignment and varying porosity features within tubular scaffolds for potential tissue engineering applications.

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Section: Discussionmentioning

confidence: 99%

Tubular Scaffold with Shape Recovery Effect for Cell Guide Applications

Hossain

Zhu

Felfel

et al. 2015

JFB

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“…It has a low viscosity, which allows it to be atomised into fine droplets. It is non-sticky, and therefore can be applied easily, and has a minimum film-forming temperature (MFT) of 18 °C that can be further lowered by addition of plasticisers, which also improves the flexibility of the film [37].…”

Section: Coated Pellets (Reservoir-type Multiparticulate Drug Delimentioning

confidence: 99%

Oral Modified Release Multiple-Unit Particulate Systems: Compressed Pellets, Microparticles and Nanoparticles

et al. 2018

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Oral modified-release multiparticulate dosage forms, which are also referred to as oral multiple-unit particulate systems, are becoming increasingly popular for oral drug delivery applications. The compaction of polymer-coated multiparticulates into tablets to produce a sustained-release dosage form is preferred over hard gelatin capsules. Moreover, multiparticulate tablets are a promising solution to chronic conditions, patients’ adherence, and swallowing difficulties if incorporated into orodispersible matrices. Nonetheless, the compaction of multiparticulates often damages the functional polymer coat, which results in a rapid release of the drug substance and the subsequent loss of sustained-release properties. This review brings to the forefront key formulation variables that are likely to influence the compaction of coated multiparticulates into sustained-release tablets. It focusses on the tabletting of coated drug-loaded pellets, microparticles, and nanoparticles with a designated section on each. Furthermore, it explores the various approaches that are used to evaluate the compaction behaviour of particulate systems.

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“…But, care has to be taken during coating of aqueous dispersion as the film formation mechanism from these dispersions is complex. Sometimes film is not completely coalesced during coating and further gradual coalescence upon storage leads to unstable release profiles (Shao et al, 2002;Muschert et al, 2009b;Kolter et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Polymer blend: a new approach for eliminating curing effect of aqueous dispersion coatings

Abbas

Irfan

Zahoor³

et al. 2020

Braz. J. Pharm. Sci.

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The aim of present work was to investigate blends of Eudragit ® NE 30D with Aquacoat ® ECD using different ratios to eliminate curing effect associated with individual polymers. Propranolol HCl 10% w/w was layered onto sugar cores using 5% w/w HPMC as a binder. Drug-layered-cores were coated either with pure or blends of Aquacoat ® ECD: Eudragit ® NE 30D in a fluidized bed coater to obtain 20% w/w coating level. Talc 35% w/w was used as anti-tacking agent. The pellets were characterized for in vitro dissolution studies, morphology, water uptake-weight loss, osmolality and adhesion of coating after curing at 60 °C or 60 °C/75% RH for 24 h. The findings revealed that Aquacoat ® ECD coated pellets showed curing effect due to further gradual coalescence of polymeric particles which resulted into better film formation upon curing. In contrast, the curing effect of Eudragit ® NE 30D coated pellets was caused by decrease in adhesion of coatings after curing which provided entirely different swelling behavior of uncured (localized swelling) and cured (uniform swelling) pellets. The undesired curing effect of individual polymers was eliminated by using their blends in appropriate ratio.

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Polyvinyl acetate-based film coatings

Cited by 47 publications

References 19 publications

Tubular Scaffold with Shape Recovery Effect for Cell Guide Applications

Tubular Scaffold with Shape Recovery Effect for Cell Guide Applications

Oral Modified Release Multiple-Unit Particulate Systems: Compressed Pellets, Microparticles and Nanoparticles

Polymer blend: a new approach for eliminating curing effect of aqueous dispersion coatings

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