Polyvinyl alcohol composite nanofibres containing conjugated levofloxacin-chitosan for controlled drug release

Jalvandi, Javid; White, Max; Gao, Yuan; Truong, Yen Bach; Padhye, Rajiv; Kyratzis, Ilias Louis

doi:10.1016/j.msec.2016.12.112

Cited by 84 publications

(44 citation statements)

References 50 publications

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“…4A). A variety of drug-loaded bers were prepared using simple blending electrospinning, such as antibiotics, 85 cytostatic drugs, 86,87 and anti-inammatory analgesics loaded bers. 88 However, simple blending electrospinning has many shortcomings in drug delivery: sensitive drug molecules, proteins, and DNA are oen denatured and lose their biological activity in the organic solvents used in simple blending electrospinning, the encapsulation efficiency of the prepared ber is low, the distribution of drugs in the bers is uneven, and the sudden release of drug is obvious.…”

Section: Simple Blending Electrospinningmentioning

confidence: 99%

Electrospun fibers and their application in drug controlled release, biological dressings, tissue repair, and enzyme immobilization

et al. 2019

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Section: Simple Blending Electrospinningmentioning

confidence: 99%

Electrospun fibers and their application in drug controlled release, biological dressings, tissue repair, and enzyme immobilization

et al. 2019

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“…The thermal stability of the chitosan conjugate is closely related to polysaccharides and bioactive substances. Some studies have shown that the introduction of exogenous active substances can lead to a decrease in the thermal stability of chitosan, which may be due to the weakening of the strong intramolecular bonding in the chitosan chain and the obstruction of chitosan chain packing due to the coupling reaction [41,74,113]. This decrease in thermal stability usually does not affect the actual application of chitosan, because the structural modification only partially reduces the thermal stability of chitosan, and its conjugates still have high thermal stability (usually up to 200 • C) [113].…”

Section: Physiochemical Properties and Antimicrobial Activitiesmentioning

confidence: 99%

“…Sometimes, a solubilizing moiety or linker is needed. Based on this conjugation strategy, active ingredients such as caffeic acid [31], ferulic acid [32], tannic acid [33], catechin [34], curcumin [35], eurycomanone [36], streptomycin [37], gibberellin [38], cysteine [39], lysozyme [40], levofloxacin [41], cefuroxime [42] were reported to succeed in coupling with chitosan.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Chitosan Conjugates: Current Synthetic Strategies and Potential Applications

Qin

2020

IJMS

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As a natural polysaccharide, chitosan possesses good biocompatibility, biodegradability and biosafety. Its hydroxyl and amino groups make it an ideal carrier material in the construction of polymer-drug conjugates. In recent years, various synthetic strategies have been used to couple chitosan with active substances to obtain conjugates with diverse structures and unique functions. In particular, chitosan conjugates with antimicrobial activity have shown great application prospects in the fields of medicine, food, and agriculture in recent years. Hence, we will place substantial emphasis on the synthetic approaches for preparing chitosan conjugates and their antimicrobial applications, which are not well summarized. Meanwhile, the challenges, limitations, and prospects of antimicrobial chitosan conjugates are described and discussed.

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“…Berbagai penelitian yang telah dilakukan sebelumnya telah berhasil membuat serat nano komposit kitosan-PVA/PEO dengan partikel obat berukuran nano untuk sistem penghantaran obat. [7][8][9] Berdasarkan studi beberapa literatur, kombinasi kitosan-PEO mampu membentuk serat nano dengan morfologi yang baik pada rasio kitosan yang lebih tinggi dibandingkan dengan menggunakan kitosan-PVA. 2,9,10 Rasio kitosan yang lebih tinggi dari polimer sintetik lebih disukai karena kitosan merupakan polimer yang tersedia melimpah di alam dan bersifat antibakteri serta antiinflamasi.…”

Section: Gambar 2 Struktur Kimia (A) Pva Dan (B) Peounclassified

Optimasi Parameter Larutan Dan Parameter Proses Pemintalan Elektrik Pada Pembuatan Serat Nano Berbahan Dasar Kitosan/Peo

Yulina

Winiati

Bonadies³

et al. 2018

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ABSTRAKSerat nano kitosan telah berhasil dibuat dengan penambahan polietilen oksida (PEO) sebagai polimer sekunder pada kondisi larutan dan parameter proses pemintalan elektrik yang optimum. Pada penelitian ini, larutan polimer kitosan-PEO pada berbagai konsentrasi (1,6; 2,0; 2,4; 3,2; 3,6; dan 4,0 wt%) dan rasio (3:2, 3:1, dan 1:1) dipintal secara elektrik (electrospinning) untuk memperoleh serat dengan morfologi paling baik. Selain kondisi larutan, parameter proses pintal elektrik yang penting seperti tegangan, laju alir umpan, dan jarak antara jarum dengan kolektor juga disesuaikan untuk mendapatkan proses dengan kondisi jet polimer yang stabil. Serat nano yang terbaik, yakni tanpa butiran polimer (polymer microspheres) dan minim jumlah manik-manik (beads) berhasil diperoleh pada konsentrasi kitosan-PEO 4 wt% dan rasio 3:2. Parameter proses yang digunakan untuk mendapatkan serat ini yaitu tegangan 30 kV, laju alir umpan 0,3 ml/jam, dan jarak antara jarum dan kolektor 30 cm. Karakterisasi morfologi serat dari setiap eksperimen dilakukan dengan menggunakan mikroskop Phenom. Selanjutnya, serat nano terbaik yang diperoleh dikarakterisasi dengan menggunakan SEM dan diameter rata-rata serat diukur dengan aplikasi ImageJ. Hasil menunjukkan bahwa serat nano yang dihasilkan pada kondisi optimum memiliki diameter rata-rata 68 nm dan distribusi ukuran diameter serat tersebar cukup lebar mulai dari 30-150 nm.Kata kunci: serat nano, pemintalan elektrik, kitosan, polietilen oksida (PEO), optimasi parameter ABSTRACT Synthesis of chitosan nanofibers was successfully achieved by adding polyethylene oxide (PEO) as the secondary polymer at the optimized electrospinning solution condition and process parameters. In this research, chitosan-PEO blended polymer solution with varied concentration (1,4; 2,0; 2,4; 3,2; 3,6; and 4,0 wt%) and ratio (3:2, 3:1 and 1:1) was electrospun to obtain fibers with the best morphology. Furthermore, the important electrospinning process parameters, such as electrical potential, feed flow rate, and distance between the needle and collector were also adjusted in order to get a stable polymer jet during the spinning process. The best nanofibers without polymer microspheres and minimum beads was obtained at chitosan-PEO concentration and ratio of 4 wt% and 3:2, respectively. These nanofibers were fabricated at the optimized process parameters, i.e. electrical potential of 30 kV, feed flowrate of 0,3 ml/hour, and distance between needle and collector of 30 cm. Fiber morphology was observed using Phenom microscopy at every single experiment. Later, the optimized nanofibers with best morphology was characterized using SEM and the average fiber diameter was measured using ImageJ software. Result has showed that the optimized nanofibers has an average diameter of 68 nm with a broad fiber size distribution from 30 to 150 nm.

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Polyvinyl alcohol composite nanofibres containing conjugated levofloxacin-chitosan for controlled drug release

Cited by 84 publications

References 50 publications

Electrospun fibers and their application in drug controlled release, biological dressings, tissue repair, and enzyme immobilization

Electrospun fibers and their application in drug controlled release, biological dressings, tissue repair, and enzyme immobilization

Antimicrobial Chitosan Conjugates: Current Synthetic Strategies and Potential Applications

Optimasi Parameter Larutan Dan Parameter Proses Pemintalan Elektrik Pada Pembuatan Serat Nano Berbahan Dasar Kitosan/Peo

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