Polyvinyl Alcohol/Soursop Leaves Extract Composite Nanofibers Synthesized Using Electrospinning Technique and their Potential as Antibacterial Wound Dressing

Aruan, Neni Mona; Sriyanti, Ida; Edikresnha, Dhewa; Suciati, Tri; Munir, Muhammad Miftahul; Khairurrijal, Khairurrijal

doi:10.1016/j.proeng.2017.03.006

Cited by 62 publications

(54 citation statements)

References 7 publications

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“…PVA polymer has either been used alone or combined with other biodegradable polymers and electrospun to form scaffolds for various applications. Furthermore, PVA has also been blended and electrospun with active ingredients such as hyaluronic acid/L-arginine, soursop leaves extract, silver nanoparticles and curcumin for wound healing [ 28 , 29 , 30 , 31 ]. Recently, we have developed, for the first time, a PVA bioactive wound dressing containing TE which showed accelerated wound healing [ 32 ].…”

Section: Introductionmentioning

confidence: 99%

Influence of PVA Molecular Weight and Concentration on Electrospinnability of Birch Bark Extract-Loaded Nanofibrous Scaffolds Intended for Enhanced Wound Healing

Mwiiri

Daniels

2020

Molecules

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Triterpenes from the outer bark of birch (TE) are known for various pharmacological effects including enhanced wound healing. Apart from an already authorized oleogel, electrospun nanofiber mats containing these triterpenes in a polyvinyl alcohol (PVA) matrix appear to be an advantageous application form. The effects of PVA molecular weight and concentration on the fiber morphology have been investigated. Three different molecular weights of PVA ranging from 67 to 186 kDa were used. The concentration of PVA was varied from 5 to 20 wt%. Polymer solutions were blended with colloidal dispersions of birch bark extract at a weight ratio of 60:40 (wt.%). The estimated viscosity of polymer solutions was directly linked to their concentration and molecular weight. In addition, both pure and blended solutions showed viscoelastic properties with a dominant viscous response in the bulk. Fiber morphology was confirmed using scanning electron microscopy (SEM). Both polymer concentration and molecular weight were found to be significant factors affecting the diameter of the fibers. Fiber diameter increased with a higher molecular weight and polymer concentration as more uniform fibers were obtained using PVA of higher molecular weight (146–186 kDa). In vitro drug release and ex vivo permeation studies indicated a faster drug release of betulin from electrospun scaffolds with lower PVA molecular weight. Our research suggests that the fabricated TE-loaded PVA electrospun dressings represent potential delivery systems of TE for wound care applications.

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Section: Introductionmentioning

confidence: 99%

Influence of PVA Molecular Weight and Concentration on Electrospinnability of Birch Bark Extract-Loaded Nanofibrous Scaffolds Intended for Enhanced Wound Healing

Mwiiri

Daniels

2020

Molecules

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“…One such plant is Tridax procumbentsis , which has been successfully transferred into nanofibrous mats and blended with PVA by Ganesan et al They also examined the antimicrobial activity of these nanofibrous mats and found that the natural potential of plants can be effectively shifted to a structure that can be used for medicinal treatments [ 22 ]. Likely, Avci et al prepared antibacterial PVA and poly(ethylene oxide) nanofibers incorporating henna leaf extracts [ 23 ], and a wound dressing technique having an antibacterial activity was successfully prepared by PVA loaded with soursop leaf extract by Aruana and his group [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

Electrospinning Fabrication of Poly(vinyl alcohol)/Coptis chinensis Extract Nanofibers for Antimicrobial Exploits

Yang

Kim²,

Kim³

et al. 2018

Nanomaterials

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Coptis chinensis (CC) is used in conventional Chinese medicine. The main active components of CC are isoquinoline alkaloids, including berberine, coptisine, palmatine, and magnoflorine; all these are known to have several pharmacological properties. Poly(vinyl alcohol) (PVA) is a well-known synthetic biocompatible polymer suitable for a range of pharmaceutical uses; it can be used as a matrix for the incorporation of functional materials and has a wide range of applications in the cosmetics, food, pharmaceutical, and packaging industries. In this study, PVA-based electrospun nanofibers containing CC extract were successfully fabricated. Furthermore, the effects of different CC extract contents on the morphologies, and antimicrobial and antifungal properties of PVA/CC extract nanofibers were investigated. Morphological changes were observed using different molecular weights of PVA. For characterization, field-emission scanning electron microscopy, thermogravimetric analysis, and Fourier transform infrared analysis were performed. The effectiveness of these nanofibers has been demonstrated by evaluating the thermal stability against Staphylococcus aureus, antimicrobial activity against Staphylococcus aureus and Staphylococcus epidermidis, and the antifungal activity against the fungi Aureobasidium pullulans and Penicillium pinophilum. The PVA/CC extract nanofibers were found to have excellent antibacterial and antifungal activity and thermal stability; hence, their use in medicinal sectors is highly recommended.

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“…aureus bacteria was investigated. The inhibition zone for the concentrations of 8%, 12%, and 14% of the extract was 1, 2, and 4 mm, respectively (Aruan, Sriyanti, Edikresnha, Suciati, & Munir, 2017).…”

Section: The Types Of Plant Compounds Used In Electrospinningmentioning

confidence: 99%

Medicinal plants used in wound dressings made of electrospun nanofibers

Fatehi

Abbasi

2020

J Tissue Eng Regen Med

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Nanofibers are a type of nanostructures, which due to their unique properties can be used in wound dressing, and electrospinning is a good way to produce them. The benefits of wound dressings made of electrospun nanofibers include a large surface area to volume ratio, high absorption of secretions from the wound, and high air permeability, mimicking the morphology of extracellular matrix (ECM) of the damaged tissue and the possibility of the gradual release of the drug agents loaded on nanofibers. Because of the adaptability of plants to the body, low side effects and the prevalence of antibiotic resistance, interest in using plants is increasing. Combining nanofibers with plants is a way to integrate the physical properties of the structure of nanofibers and the chemical and antibacterial properties of the plants. In recent years, many plants in the forms of extracts, essential oils, and pure active ingredients have been used in the electrospininng and production of nanofibercontaining plants; some of the plants may be a good choice for wound dressings made of electrospun nanofibers.

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Polyvinyl Alcohol/Soursop Leaves Extract Composite Nanofibers Synthesized Using Electrospinning Technique and their Potential as Antibacterial Wound Dressing

Cited by 62 publications

References 7 publications

Influence of PVA Molecular Weight and Concentration on Electrospinnability of Birch Bark Extract-Loaded Nanofibrous Scaffolds Intended for Enhanced Wound Healing

Influence of PVA Molecular Weight and Concentration on Electrospinnability of Birch Bark Extract-Loaded Nanofibrous Scaffolds Intended for Enhanced Wound Healing

Electrospinning Fabrication of Poly(vinyl alcohol)/Coptis chinensis Extract Nanofibers for Antimicrobial Exploits

Medicinal plants used in wound dressings made of electrospun nanofibers

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