Population-Based Case-Control Study of Renin-Angiotensin System Genes Polymorphisms and Hypertension among Hispanics

Abstract

The effect of polymorphisms of the RAS genes on the incidence of hypertension seems to be populationdependent. We studied the effects of the angiotensinogen T174M and M235T, angiotensin converting enzyme insertion/deletion (ACE I/D), and angiotensin II receptor 1 (AT1R) A1166C gene polymorphisms on the risk of hypertension among Hispanics. We selected all cases (n =256) and 257 age and sex groupmatched controls from a random sample of free living Colombians (n =2,989). Logistic regression was used to estimate the independent effect of each polymorphism. All polymorphisms were in Hardy-Weinberg equi-

Relationship among angiotensin-converting enzyme polymorphism, cardiovascular risk, and osteoporotic fractures

“…Our findings are in agreement with Bautista et al (10); therefore, we found no relationship between DD genotype and cardiovascular risk. In contrast to our expectations, we found no association with osteoporotic fracture incidence, although some studies suggest the possible existence of an ACE genotype role in bone mineral density in women (16).…”

“…However, there is contradictory information on the link between I/D polymorphism and CVRF (10). Moreover, there is a lack of studies related to ACE genotypes and osteoporosis (14,16).…”

Association of ACE ID and ACE G2350A polymorphism with increased blood pressure in persons exposed to different sound levels in Pakistan

“…A large meta-analysis by Staessen et al (1997) revealed that homozygous D allele causes 10% increased risk for hypertension when compared to that of homozygous I allele in women and Asians. For Hispanic population, DD allele was found independent risk factor of hypertension (Bautista et al 2008). Similar results were observed in population of China, male population of Bangladesh, Japan and Argentina (Zhang et al 2007;Morshed et al 2002;Higaki et al 2000;Jiménez et al 2007).…”

A study on the polymorphisms of the renin–angiotensin system pathway genes for their effect on blood pressure levels in males from Algeria

“…Bautista et al found that the AGT M235T polymorphism was not significantly associated with hypertension and BP values in a Hispanic population. 22 Similar results were obtained in the Surinamese in The Netherlands: Study on Ethnicity and Health (SUNSET) study 23 and in meta-analyses realized in Japanese populations. 24 On the other hand, the AGT M235T SNP was associated with hypertension in many countries with subjects of Caucasian, 25 Taiwanese, 26 Turkish 27 and Dutch 28 origins.…”