Population-based demographic study of karyotypes in 1709 patients with adult Acute Myeloid Leukemia

Abstract

Few large demographic studies of acute myeloid leukemia (AML) are derived from population-based registries. Demographic and karyotypic data were provided for AML cases from two regional leukemia registry databases in Scotland and the Northern Region of England. A population-based dataset was compiled, comprising 1709 patients aged 416 years (1235 North England/474 Scotland patients). The most common cytogenetic abnormalities involved chromosomes 5 and/or 7 (17%). Patients with the following abnormal chromosome 5/7 combinations: À5, del(5q), À5/À7 and del(5q)/À7 represented a significantly older population (Po0.01, ANOVA). t(8;21) was the only 'favourable' karyotype found in older age. Karyotypic complexity varied within chromosome 5/7 combination groups; those containing À5, À5/À7, À5/del(7q), del(5q)/À7 or del(5q)/ del(7q) combinations were significantly more frequently complex than those containing À7 and del(7q) (Po0.01, v 2 test). Additional recurring cytogenetic abnormalities within complex karyotypes containing chromosome 5/7 combinations included (in order of frequency), abnormalities of chromosomes 17, 12, 3 and 18. Complex karyotypes not involving chromosomes 5 or 7 represented 30% of all complex karyotypes, occurred in younger patients than those involving chromosomes 5 and 7, and frequently included additional trisomy 8 (26%). In conclusion, we describe subgroups within adverse karyotypes, with different demographics, degree of complexity and additional chromosome abnormalities.

Monosomal Karyotypes among 1147 Chinese Patients with Acute Myeloid Leukemia: Prevalence, Features and Prognostic Impact

“…A successful analysis rate of 83% and a normal karyotype frequency of 45% were comparable to most published series (Sanderson et al, 2006;Cheng et al, 2009), reflecting the high quality of data in the present study. Initially, we determined the frequency and baseline character of MK in Chinese AML patients.…”

Cytogenetic profile of de novo acute myeloid leukemia: a study based on 1432 patients in a single institution of China

“…[18][19][20][21] Abnormalities of 11q23 were observed in 1.2% of cases, similar to earlier studies in which it occurred in no more than 4% of AML patients. [18][19][20][21] The age distribution is different from population to population. The age-specific incidence of AML in our cohort was calculated based on the population of Zhejiang Province in China.…”

“…This frequency was lower than that seen in most western countries (6-13.9%). 6,18,20,21 The partial and/or complete deletion of chromosomes 5 and 7 accounted for 0.8 and 1.4% of our cases. This has been seen in 6-15% of de novo AML in other reports.…”

“…6,[17][18][19][20][21][22][23][24][25][26] The results of this study compared with several population-based and regional studies are detailed in Table 3. These represent most large-scale published studies that deal exclusively with de novo AML.…”

“…Such a large difference might cause a statistical variation. (3) Ethnic differences should Table 3 Comparison of the karyotypic patterns in AML patients Reference This study Rowley 17 Bacher et al 6 Byrd et al 18 Enjeti et al 19 Sanderson et al 20 Grimwade et al 17 and Grimwade et al 5,20 are trial based, whereas others are population based.…”