Population-based pediatric reference intervals for HbA1c, bilirubin, albumin, CRP, myoglobin and serum enzymes

Rödöö, Peo; Ridefelt, Peter; Aldrimer, Mattias; Niklasson, F; Gustafsson, Jan Åke; Hellberg, Dan

doi:10.3109/00365513.2013.783931

Cited by 36 publications

(21 citation statements)

References 23 publications

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“…Prospective and community-based studies for pediatric reference intervals have been performed for a large number of healthy children from Sweden, Canada, Denmark, and Germany [ 14 15 16 17 18 19 20 21 22 23 ]. These studies presented pediatric reference intervals for hematology and clinical chemistry parameters as well as hormones and lipids.…”

Section: Discussionmentioning

confidence: 99%

Reference Intervals of Hematology and Clinical Chemistry Analytes for 1-Year-Old Korean Children

et al. 2016

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BackgroundReference intervals need to be established according to age. We established reference intervals of hematology and chemistry from community-based healthy 1-yr-old children and analyzed their iron status according to the feeding methods during the first six months after birth.MethodsA total of 887 children who received a medical check-up between 2010 and 2014 at Boramae Hospital (Seoul, Korea) were enrolled. A total of 534 children (247 boys and 287 girls) were enrolled as reference individuals after the exclusion of data obtained from children with suspected iron deficiency. Hematology and clinical chemistry analytes were measured, and the reference value of each analyte was estimated by using parametric (mean±2 SD) or nonparametric methods (2.5-97.5th percentile). Iron, total iron-binding capacity, and ferritin were measured, and transferrin saturation was calculated.ResultsAs there were no differences in the mean values between boys and girls, we established the reference intervals for 1-yr-old children regardless of sex. The analysis of serum iron status according to feeding methods during the first six months revealed higher iron, ferritin, and transferrin saturation levels in children exclusively or mainly fed formula than in children exclusively or mainly fed breast milk.ConclusionsWe established reference intervals of hematology and clinical chemistry analytes from community-based healthy children at one year of age. These reference intervals will be useful for interpreting results of medical check-ups at one year of age.

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Section: Discussionmentioning

confidence: 99%

Reference Intervals of Hematology and Clinical Chemistry Analytes for 1-Year-Old Korean Children

et al. 2016

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“…Approximately 50 analytes were measured, and the results for the other analytes have been presented elsewhere [18,19,20,21]. The Regional Ethical Review Board of Uppsala (No.…”

Section: Methodsmentioning

confidence: 99%

“…Abbott Scandinavia AB (Solna, Sweden) sponsored the reagents. Details of the laboratory methods used have been published elsewhere [18,19,20,21]. Intact PTH (iPTH) and 25(OH)-vitamin D was measured with Abbott reagents on Abbott Architect.…”

Section: Methodsmentioning

confidence: 99%

Alkaline Phosphatase in Healthy Children: Reference Intervals and Prevalence of Elevated Levels

Ridefelt¹,

Gustafsson

Aldrimer

et al. 2014

Horm Res Paediatr

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Background: Transient hyperphosphatasemia (TH) is an often unnoticed benign entity, primarily affecting children below 5 years of age. However, the prevalence among healthy children is unknown. We used data from a Swedish pediatric reference interval project to estimate the prevalence of high alkaline phosphatase (ALP) among healthy children and to calculate pediatric reference intervals. Methods: Blood was collected from 699 subjectively healthy children aged 6 months to 18 years. After exclusion of subjects with high ALP, age- and gender-specific reference intervals were calculated. Results: Six children had ALP levels >16.7 µkat/l (>1,000 U/l), including 4 females and 2 males aged 7-22 months. The prevalence in the age group from 6 months to 2 years was 6.2% (6/97). None of the older children had levels of ALP >16.7 µkat/l. The study did not include the follow-up of these apparently healthy children. Consequently, conditions others than TH explaining the elevated ALP could not be excluded. However, general chemistry analyses, such as liver enzymes, calcium, intact PTH and vitamin D, were essentially normal in these children. Conclusions: The prevalence of high ALP among subjectively healthy children was approximately 2.4% below 5 years of age and 6.2% below 2 years. Reference intervals vary with age and gender.

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“…Details of the results in the Swedish study for general clinical chemistry, hematology and certain hormones are available ( 1 – 4 ). The Swedish study only contains data on children older than 6 months of age.…”

Section: Resultsmentioning

confidence: 99%

Population-Based Pediatric Reference Intervals in General Clinical Chemistry: A Swedish Survey/Pedijatrijski Referentni Intervali U Opštoj Kliničkoj Hemiji Zasnovani Na Ispitivanju Populacije: Švedsko Ispitivanje

Ridefelt¹

2014

Journal of Medical Biochemistry

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SummaryVery few high quality studies on pediatric reference intervals for general clinical chemistry and hematology analytes have been performed. Three recent prospective community-based projects utilising blood samples from healthy children in Sweden, Denmark and Canada have substantially improved the situation. The Swedish survey included 701 healthy children. Reference intervals for general clinical chemistry and hematology were defined.

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Population-based pediatric reference intervals for HbA1c, bilirubin, albumin, CRP, myoglobin and serum enzymes

Cited by 36 publications

References 23 publications

Reference Intervals of Hematology and Clinical Chemistry Analytes for 1-Year-Old Korean Children

Reference Intervals of Hematology and Clinical Chemistry Analytes for 1-Year-Old Korean Children

Alkaline Phosphatase in Healthy Children: Reference Intervals and Prevalence of Elevated Levels

Population-Based Pediatric Reference Intervals in General Clinical Chemistry: A Swedish Survey/Pedijatrijski Referentni Intervali U Opštoj Kliničkoj Hemiji Zasnovani Na Ispitivanju Populacije: Švedsko Ispitivanje

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