Populations of follicles in F344/N rats during aging

Nishijima, Ken‐ichi; Tanaka, Shin; Sakamoto, Shinsuke H.; Kuwahara, Sachi; Ohno, Tamio; Kitajima, Shuji

doi:10.1016/j.repbio.2013.03.003

Cited by 5 publications

(10 citation statements)

References 19 publications

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“…; Nishijima et al. , , , , ; Sone et al. ), and some of them correlate with the inflection points in our results.…”

Section: Discussionsupporting

confidence: 81%

“…Nevertheless, follicles and the corpora lutea were observed in the rat ovary even at 36 months (ca. 1100 days) of age (Nishijima et al 2013), which indicates that estrogens were retained. This may explain bone parameter maintenance in the old rats investigated in the present study.…”

Section: Discussionmentioning

confidence: 98%

“…1100 days) of age (Nishijima et al. ), which indicates that estrogens were retained. This may explain bone parameter maintenance in the old rats investigated in the present study.…”

Section: Discussionmentioning

confidence: 99%

“…; Nishijima et al. ). Additionally, we previously revealed age‐dependent changes in the mandible focusing on the periodontal bone (Arai et al.…”

Section: Introductionmentioning

confidence: 97%

“…Therefore, it is important to identify specific aging properties of the animals so that experimental results may be extrapolated to humans. F344/N, an inbred strain of rat, is one of the most commonly used model animals in gerontological and geriatric sciences; aging properties in the F344/N rat have been investigated from various aspects, including survival (Tanaka et al 2000a(Tanaka et al ,b, 2001, respiratory tract characteristics (Yamamoto et al 2003a,b), and reproduction (Sone et al 2007;Nishijima et al 2013). Additionally, we previously revealed age-dependent changes in the mandible focusing on the periodontal bone (Arai et al 2005), the condyle (Nishijima et al 2010), and occlusal tooth wear (Nishijima et al 2007(Nishijima et al , 2009 in F344/N rats.…”

Section: Introductionmentioning

confidence: 99%

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Age‐dependent changes of the mandible bone throughout the lifespan in female F344/N rat

et al. 2018

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Age-dependent changes of the mandible bone in female F344/N rats, aged 22-1196 days, were analyzed using physiological bone properties and morphology. Bone weight, bone area, bone mineral components, and bone mineral density were assessed using dual-energy X-ray absorptiometry. The bone weight, bone area, bone mineral components, and bone mineral density increased rapidly until approximately 150 days of age, increased gradually thereafter, and then stabilized or decreased after 910 days of age. The ratio of bone mineral components to bone weight (bone mineral ratio) increased rapidly until approximately 43 days of age and stabilized thereafter. Size of the mandible, which was measured at 13 points on mandible surface, increased with age, and the rate of change showed a similar pattern to the other parameters. From a principal component analysis on morphometric measurements, principal component 1 (size factor) increased proportionally with age, whereas principal component 2 (shape factor) decreased until approximately 88 days of age and then increased after 365 days of age. As a result, the scatter plots for principal component 1 and principal component 2 were V-shaped, which indicates that the mandible developed in size, with deformation at younger ages, and recovered its original shape later in life. Our results revealed the occurrence of inflection points at approximately 43, 88, 150, 365, and 910 days of age. Some of these ages corresponded to transition points revealed by the age-dependent changes of the occlusal mandibular condyle and tooth wear in the same rat.

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“…; Nishijima et al. , , , , ; Sone et al. ), and some of them correlate with the inflection points in our results.…”

Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 98%

“…1100 days) of age (Nishijima et al. ), which indicates that estrogens were retained. This may explain bone parameter maintenance in the old rats investigated in the present study.…”

Section: Discussionmentioning

confidence: 99%

“…; Nishijima et al. ). Additionally, we previously revealed age‐dependent changes in the mandible focusing on the periodontal bone (Arai et al.…”

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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Age‐dependent changes of the mandible bone throughout the lifespan in female F344/N rat

et al. 2018

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Antral follicle count, oocyte production and embryonic developmental competence of senescent Nellore (Bos indicus) cows

Alvarez

Bayeux²,

Joaquim

et al. 2021

Theriogenology

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Protective role of Ficus deltoidea against BPA-induced impairments of the follicular development, estrous cycle, gonadotropin and sex steroid hormones level of prepubertal rats

2018

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Ficus deltoidea is one of the well-known medicinal plants in Malaysia that is traditionally used by the Malay community to treat various ailments and for maintenance of female reproductive health. The objective of this study is to evaluate the potential protective roles of Ficus deltoidea against BPA-induced toxicity of the pituitary-ovarian axis in pre-pubertal female rats. In this study, four groups of pre-pubertal female Sprague Dawley rats were administered with the followings by oral gavage for a period of six weeks: NC (negative control- treated with vehicle), PC (positive control-treated with BPA at 10 mg/kg/BW), F (treated with Ficus deltoidea at 100 mg/kg/BW, then exposed to BPA at 10 mg/kg/BW) and FC (Ficus deltoidea control - treated with Ficus deltoidea at 100 mg/kg/BW). Daily vaginal smear, ovarian follicular development as well as gonadotropin and sexual-steroid hormone levels were determined. The findings showed that Ficus deltoidea demonstrated preventive role against BPA-induced toxicity on the ovaries. This was evident by the increased percentage of rats with normal estrous cycle, qualitatively reduced number of atretic follicles (as observed in histopathological examination) and normalization of the gonadotropins hormone (FSH) and sexual steroid hormone (progesterone) levels. In conclusion, Ficus deltoidea has the capability to prevent the effects of BPA toxicity in the hypothalamus-pituitary-gonadal axis of prepubertal female reproductive system, possibly due to its variety of phytochemical properties. Therefore, these findings strongly support the traditional belief that this medicinal plant is beneficial as daily dietary supplement for the maintenance of female reproductive health.

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Populations of follicles in F344/N rats during aging

Cited by 5 publications

References 19 publications

Age‐dependent changes of the mandible bone throughout the lifespan in female F344/N rat

Age‐dependent changes of the mandible bone throughout the lifespan in female F344/N rat

Antral follicle count, oocyte production and embryonic developmental competence of senescent Nellore (Bos indicus) cows

Protective role of Ficus deltoidea against BPA-induced impairments of the follicular development, estrous cycle, gonadotropin and sex steroid hormones level of prepubertal rats

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