Porous microsphere and its applications

Cai, Yunpeng; Chen, Yinghui; Hong, Xiaoyun; Liu, Zhenguo; Yuan, Weien

doi:10.2147/ijn.s41271

Cited by 63 publications

(26 citation statements)

References 68 publications

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“…This is due to the unique and controllable physicochemical properties of micro- and nanoparticles, which allow them to integrate multiple functions such as biosensing1234, targeting5678 and drug delivery91011. Recently, a wide range of studies has focused on the fabrication and characterization of new micro- and nanoparticles for biomedical purposes.…”

mentioning

confidence: 99%

Surface modification of microparticles causes differential uptake responses in normal and tumoral human breast epithelial cells

Patiño

Soriano

Barrios

et al. 2015

Sci Rep

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The use of micro- and nanodevices as multifunctional systems for biomedical applications has experienced an exponential growth during the past decades. Although a large number of studies have focused on the design and fabrication of new micro- and nanosystems capable of developing multiple functions, a deeper understanding of their interaction with cells is required. In the present study, we evaluated the effect of different microparticle surfaces on their interaction with normal and tumoral human breast epithelial cell lines. For this, AlexaFluor488 IgG functionalized polystyrene microparticles (3 μm) were coated with Polyethyleneimine (PEI) at two different molecular weights, 25 and 750 kDa. The effect of microparticle surface properties on cytotoxicity, cellular uptake and endocytic pathways were assessed for both normal and tumoral cell lines. Results showed a differential response between the two cell lines regarding uptake efficiency and mechanisms of endocytosis, highlighting the potential role of microparticle surface tunning for specific cell targeting.

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confidence: 99%

Surface modification of microparticles causes differential uptake responses in normal and tumoral human breast epithelial cells

Patiño

Soriano

Barrios

et al. 2015

Sci Rep

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“…To date, microspheres have been developed by many different methods; the emulsion method is the most widely employed. Microspheres have been developed using many novel techniques ( Cai et al, 2013 ; Hong et al, 2013 ; Jiang et al, 2016 ; Park et al, 2016 ; Wei et al, 2016 ; Xiao et al, 2016 ; Zhang et al, 2016 ). However, these methods failed to improve the hydrophobic properties of the microsphere surfaces, resulting in poor biocompatibility with biological tissue; the acidity of PLGA degradation products resulted in acid-sensitive drugs losing efficacy, inflammatory reaction, and problems with microspheres-high efficacy-loaded drug.…”

Section: Discussionmentioning

confidence: 99%

Osteoinductivity and Antibacterial Properties of Strontium Ranelate-Loaded Poly(Lactic-co-Glycolic Acid) Microspheres With Assembled Silver and Hydroxyapatite Nanoparticles

Mao

Yang

et al. 2018

Front. Pharmacol.

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Bone-related infection rates are 4–64% in long open bone fractures and nearly 1% in joint-related surgeries. Treating bone infections and infection-related bone loss is very important. The present study prepared strontium ranelate (SR)-loaded poly(lactic-co-glycolic acid) (PLGA) microspheres (PM) with assembled silver nanoparticles (AgNPs) and hydroxyapatite nanoparticles (HANPs) (SR-PM-Ag-HA) through a novel solid-in-oil nanosuspension (S/O/N) method to achieve osteoinductivity and antibacterial properties. We evaluated the microstructure, drug release, biocompatibility, osteoinductivity, and antibacterial activity in vitro. The microspheres showed a stable shape and size. The cumulative drug release reached a maximum of ∼90% after 22 days. All groups loaded with SR enhanced MC3T3-E1 cell proliferation to a greater degree than pure PM. The osteoinductivity behavior was investigated by ALP staining and real-time PCR of osteogenic differentiation marker genes. The antibacterial activity was evaluated using antibacterial ability and biofilm formation assays. SR-PM-Ag-HA greatly enhanced osteogenic differentiation and showed excellent antibacterial properties. These results indicated that SR-PM-Ag-HA could be biocompatible and suitable for drug delivery, osteoinduction, and antibiosis, and therefore, have potential applications in the treatment of bone-related infections and promotion of bone formation at infected sites.

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“…The formation of POSS-PCUU scaffold is a two-part process: the mixing and exchange of DMAC with water causing the polymer to precipitate out of solution and the dissolution of NaHCO 3 to form a sponge-like scaffold through the well-established particulate leaching method [ 58 ]. As with other systems that use the same method of manufacture, sometimes referred to as ‘salt leaching’ or ‘solvent casting’, precipitation begins as the polymer solution is lowered into the water bath [ 59 ], and so we posit that a polymer membrane is rapidly formed via DMAC-water exchange and precipitation on the surface of the polymer solution creating a ‘membrane’ [ 60 , 61 ], while NaHCO 3 dissolution within the polymer is a much slower, diffusion-governed process [ 62 ]. We further suggest that the pores formed immediately below this membrane may be created by hydrodynamic instability at the interface between the polymer and the water which either through the Gibbs-Marangoni effect [ 63 ], turbulence at the interface caused by the immersion of polymer into excess water or a combination of the two, causes defects to form at the surface.…”

Section: Discussionmentioning

confidence: 99%

Silsesquioxane polymer as a potential scaffold for laryngeal reconstruction

Mehrban

Bowen

Tait

et al. 2018

Materials Science and Engineering: C

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Cancer, disease and trauma to the larynx and their treatment can lead to permanent loss of structures critical to voice, breathing and swallowing. Engineered partial or total laryngeal replacements would need to match the ambitious specifications of replicating functionality, outer biocompatibility, and permissiveness for an inner mucosal lining. Here we present porous polyhedral oligomeric silsesquioxane-poly(carbonate urea) urethane (POSS-PCUU) as a potential scaffold for engineering laryngeal tissue. Specifically, we employ a precipitation and porogen leaching technique for manufacturing the polymer. The polymer is chemically consistent across all sample types and produces a foam-like scaffold with two distinct topographies and an internal structure composed of nano- and micro-pores. While the highly porous internal structure of the scaffold contributes to the complex tensile behaviour of the polymer, the surface of the scaffold remains largely non-porous. The low number of pores minimise access for cells, although primary fibroblasts and epithelial cells do attach and proliferate on the polymer surface. Our data show that with a change in manufacturing protocol to produce porous polymer surfaces, POSS-PCUU may be a potential candidate for overcoming some of the limitations associated with laryngeal reconstruction and regeneration.

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Porous microsphere and its applications

Cited by 63 publications

References 68 publications

Surface modification of microparticles causes differential uptake responses in normal and tumoral human breast epithelial cells

Surface modification of microparticles causes differential uptake responses in normal and tumoral human breast epithelial cells

Osteoinductivity and Antibacterial Properties of Strontium Ranelate-Loaded Poly(Lactic-co-Glycolic Acid) Microspheres With Assembled Silver and Hydroxyapatite Nanoparticles

Silsesquioxane polymer as a potential scaffold for laryngeal reconstruction

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