Porous Ti6Al4V scaffold directly fabricating by rapid prototyping: Preparation and in vitro experiment

Li, Jia Ping; Wijn, J.R. de; Blitterswijk, Clemens A. van; Groot, K. de

doi:10.1016/j.biomaterials.2005.08.033

Cited by 202 publications

(106 citation statements)

References 67 publications

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“…However, bulk titanium remains difficult to be used in bone tissue repair not only because of its poor Osteogenic properties but also its inappropriate elastic modulus for bone tissue and less space for bone cells to grow inside [3,4]. To solve the mismatching in mechanical properties, three-dimensional porous titanium scaffolds were proposed to be built to substitute bulk titanium as bone implant [5].…”

Section: Introductionmentioning

confidence: 99%

Large-scale functionalization of biomedical porous titanium scaffolds surface with TiO2 nanostructures

Qian

Zeng

et al. 2017

Sci. China Mater.

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Construction of functional porous titanium scaffold is drawing ever growing attention, due to its effectiveness in solving the mechanical mismatch between titanium implant and bone tissue. However, the poor water permeability as well as the problem in achieving uniform surface modification inside scaffold hinders the further biomedical application of porous titanium scaffold. In this study, largescale functional TiO 2 nanostructures (nanonetwork, nanoplate and nanowire) were constructed on three-dimensional porous titanium scaffolds surface via an effective hydrothermal treatment method. These nanostructures increase the hydrophilicity of the titanium scaffold surface, facilitating the cell culture medium to penetrate into the inner pore of the scaffold. Zeta potential analyses indicate that the surface electrical properties depend on the nanostructure, with nanowire exhibiting the lowest potential at pH 7.4. The influence of the nano-functionalized scaffold on protein adsorption and cell adhesion was examined. The results indicate that the nano-functionalized surface could modulate protein adsorption and bone marrow derived mesenchymal stem cells (BMSCs) adhesion, with the nanowire functionalized porous scaffold homogeneously promoting protein adsorption and BMSCs adhesion. Our research will facilitate future research on the development of novel functional porous scaffold.

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Section: Introductionmentioning

confidence: 99%

Large-scale functionalization of biomedical porous titanium scaffolds surface with TiO2 nanostructures

Qian

Zeng

et al. 2017

Sci. China Mater.

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“…Several manufacturing processes of porous titanium are known among which freeze casting (Yook et al, 2009), space holder technique (Niu et al, 2009), rapid prototyping (Li et al, 2006) or laser processing (Parthasarathy et al, 2010;Heinl et al, 2008;Krishna et al, 2007) . Freeze casting and space holder processes mostly lead to randomly distributed pores whereas rapid prototyping and laser processing are adopted when a controlled architecture is required .…”

Section: Introductionmentioning

confidence: 99%

“…In the literature, rapid prototyping and laser processing are often reported to generate bulk titanium or porous titanium with simple pore architecture (Parthasarathy et al, 2010 ;Heinl et al, 2008;Krishna et al, 2007 ;Li et al, 2006) . These techniques are generally used in the case of titanium alloys .…”

Section: Introductionmentioning

confidence: 99%

Development and mechanical characterization of porous titanium bone substitutes

Barbas

Bonnet

Lipiński

et al. 2012

Journal of the Mechanical Behavior of Biomedical Materials

158

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is an open access repository that collects the work of Arts et Métiers ParisTech researchers and makes it freely available over the web where possible. Commercially Pure Porous Titanium (CPPTi) can be used for surgical implants to avoid the stress shielding effect due to the mismatch between the mechanica l properties of titanium and bone . Most researchers in this area deal with randomly distributed pores or simple architectures in titanium alloys. The control of porosity, pore size and distribution is necessary to obtain implants with mechanical properties close to those of bone and to ensure their osseointegration . The aim of the present work was therefore to develop and characterize such a specific porous structure. First of all, the properties of titanium made by Selective Laser Melting (SLM) were characterized through experimental testing on bulk specimens. An elementary pattern of the porous structure was then designed to mimic the orthotropic properties of the human bone following several mechanical and geometrical criteria . Finite Element Analysis (FEA) was used to optimize the pattern . A porosity of 53% and pore sizes in the range of 860 to 1500 µm were fi.nally adopted . Tensile tests on porous samples were then carried out to validate the properties obtained numerically and identify the failure modes of the sam_ples. Final!y, FE elasto_plastic ana!yses were yerformed on the porous samples in order to propose a failure criterion for the design of porous substitutes . .

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“…The head moves in the z, and the process can build a part layer-by-layer. In the past, many other processes have been used to make porous metal such as compressing and sintering titanium fibers, compressing and sintering particles, plasma spraying of powder, foaming by expansion of argon filled pores, and polymeric sponge replication (Li et al, 2006). LENS™ can be used to make porous structure by designing porosity as well as controlling process parameters.…”

mentioning

confidence: 99%

“…LENS™ can be used to make porous structure by designing porosity as well as controlling process parameters. In the past, direct metal laser sintering (Khaing et al, 2001;Traini et al, 2008), direct laser forming (Hollander et al, 2006;Harrysson et al, 2008), select laser melting/select laser sintering (Vamsi Krishna et al, 2008;Yadroitsev et al, 2009), electron beam melting (Heinl et al, 2007;Parthasarathy et al, 2010;Cheng et al, 2012;de Peppo et al, 2012), multistage lost wax investment casting (Ryan et al, 2008), and 3D fiber depositing system (Li et al, 2006(Li et al, , 2007 have been used to make porous Ti6Al4V components. All these methods have their advantages and disadvantages when compared to each other.…”

mentioning

confidence: 99%

Laser Engineering Net Shaping of Microporous Ti6Al4V Filters

Gualtieri

Bandyopadhyay

2016

Front. Mech. Eng.

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In many applications, porous metal structures are necessary for proper and optimal function. Yet, these structures can be difficult to build. It is especially difficult if the pore size desired is very fine or on the microscale. For this reason, additive manufacturing processes have been looked at to build these structures. In this study, Laser Engineering Net Shaping (LENS™) processing was experimented with processing interconnected microporous structures. Using Ti6Al4V and only changing processing parameters, porous structures were created having porosity ranging from 21.5 to 15.4%. The microstructure proved to be that of traditional laser processed Ti6Al4V parts. Compression test of these samples showed that the ultimate compressive strength varied from 645 to 556 MPa. Overall, LENS™ proved to be a viable method to make unique interconnected microporous structures that could be easily added to any build without having to change the design.

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Porous Ti6Al4V scaffold directly fabricating by rapid prototyping: Preparation and in vitro experiment

Cited by 202 publications

References 67 publications

Large-scale functionalization of biomedical porous titanium scaffolds surface with TiO2 nanostructures

Large-scale functionalization of biomedical porous titanium scaffolds surface with TiO2 nanostructures

Development and mechanical characterization of porous titanium bone substitutes

Laser Engineering Net Shaping of Microporous Ti6Al4V Filters

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