Porphyrin-based covalent organic framework nanoparticles for photoacoustic imaging-guided photodynamic and photothermal combination cancer therapy

Facile Fabrication of Redox‐Responsive Covalent Organic Framework Nanocarriers for Efficiently Loading and Delivering Doxorubicin

“…For example, the combination of high surface area, tunable pore structure, and π–π stacking interactions endows COFs with high loading capacity and minimized drug leakage. In addition, their unique photoelectric properties enable COFs to serve as a promising platform for photodynamic and photothermal therapy . However, some intrinsic limitations of COFs, such as intricate and tedious preparation process of building blocks, irregular shape and size as well as uncontrolled drug release, severely restrain their practical applications in drug delivery …”

“…In addition, their unique photoelectric properties enable COFs to serve as a promising platform for photodynamic and photothermal therapy. [20][21][22] However, some intrinsic limitations of COFs, such as intricate and tedious preparation process of building blocks, irregular shape and size as well as uncontrolled drug release, severely restrain their practical applications in drug delivery. [15,18,23] In this study, we develop a facile strategy to construct redox-responsive covalent organic framework nanocarriers Covalent organic frameworks (COFs) as drug delivery systems have shown great promise, but their pharmaceutical applications are often limited by complex building blocks, tedious preparations, irregular shape, and uncontrolled drug release within target cells.…”

A COF-based nanoplatform for highly efficient cancer diagnosis, photodynamic therapy and prognosis

“…[9][10][11][12] But the poor dispersibility and unsatisfactory bioavailability caused by their large size are still the major bottlenecks for COFs to be used for biomedical applications. [13][14][15][16][17] Nanoscale COFs possessing better dispersibility and higher bioavailability are more suitable for biomedical purposes.…”

Nanoscale covalent organic frameworks as theranostic platforms for oncotherapy: synthesis, functionalization, and applications

“…Here, we will introduce the different kinds of methods to make the bread: COF-based oncotherapy examples. Till now, COFs have been used as drug delivery carriers, 221,[396][397][398][399][400][401][402][403] phototherapy reagents, 163,216,223,261,[404][405][406][407][408][409][410] and combination therapy platforms 161,162,220,[411][412][413][414][415] for tumor therapeutics ( Table 5).…”