The use of new technology from Pharma Industry 4.0 promotes sustainable production of value, makes pharmaceutical industry more flexible, clever and customized and thereby helps pharmaceutical companies to achieve economic benefit in long term. The present review discusses about the implications caused in enhancing pharmaceutical production and also investigate that how industry 4.0 aids in increasing the production. The review also discusses about the challenges faced by pharma industries 4.0 and addresses research opportunities faced in pharma industries 4.0. From the review it was observed that, main barriers which come in the way of increasing the production are high cost, time consuming design and framework development, seniors unsupportiveness, lack of good training skills, inadequate business inducement, lack of co-operation and communications. Further it was observed that, smart production system has led to the development of the increased production, but still difficulties and impediment to smart production should be considered in order to achieve expertize in supply chain managerial and sustainable practices.