Portrait of inflammatory response to ionizing radiation treatment

Maggio, Federica Maria Di; Minafra, Luigi; Forte, Giusi Irma; Cammarata, Francesco Paolo; Lio, Domenico; Messa, Cristina; Gilardi, M.C.; Bravatà, Valentina

doi:10.1186/s12950-015-0058-3

Cited by 234 publications

(197 citation statements)

References 163 publications

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“…4, 5 and 6 respectively). This is in agreement with other studies reporting the increase of radiation induced pro-inflammatory cytokines and growth factors 27,28 and decrease of anti-inflammatory biomarkers 29 .…”

Section: Fig 6: Radio-modifying Effect Of Cucurbits Lagenaria Sicersupporting

confidence: 94%

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2018

IJPSR

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Section: Fig 6: Radio-modifying Effect Of Cucurbits Lagenaria Sicersupporting

confidence: 94%

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2018

IJPSR

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“…Key molecules involved in radiation-induced immune responses and non-radiated tissue damage include transcription factors (such as NF-κB), protein kinases (such as MAPK), cytokines (such as IL-1β, IL-4, IL-5, IL-6, IL-10, IL-12, IL-18, IL-33, and IFN-γ), TNF-α, and growth factors (such as TGF-β, bFGF, IGF-1, and PDGF) (Di Maggio et al 2015). Inflammatory cytokines and growth factors like TGF-β and IGF-1 stimulate the production of prostaglandins, ROS and NO from macrophages, T cells, neutrophils, and non-immune cells.…”

Section: Immunogenicity Of Ionizing Radiationmentioning

confidence: 99%

The melatonin immunomodulatory actions in radiotherapy

et al. 2017

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Radiotherapy has a key role in cancer treatment in more than half of patients with cancer. The management of severe side effects of this treatment modality is a limiting factor to appropriate treatment. Immune system responses play a pivotal role in many of the early and late side effects of radiation. Moreover, immune cells have a significant role in tumor response to radiotherapy, such as angiogenesis and tumor growth. Melatonin as a potent antioxidant has shown appropriate immune regulatory properties that may ameliorate toxicity induced by radiation in various organs. These effects are mediated through various modulatory effects of melatonin in different levels of tissue reaction to ionizing radiation. The effects on the DNA repair system, antioxidant enzymes, immune cells, cytokines secretion, transcription factors, and protein kinases are most important. Moreover, anti-cancer properties of melatonin may increase the therapeutic ratio of radiotherapy. Clinical applications of this agent for the management of malignancies such as breast cancer have shown promising results. It seems anti-proliferative, anti-angiogenesis, and stimulation or suppression of some immune cell responses are the main anti-tumor effects of melatonin that may help to improve response of the tumor to radiotherapy. In this review, the effects of melatonin on the modulation of immune responses in both normal and tumor tissues will be discussed.

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“…The role of the NF-jB pathway activation in the early radiation response has already been clearly established. 31 The in vitro experiments were mainly performed on tumor cell lines and there were relatively few investigations assessing the effect of NF-jB inhibitors on normal cells. The small animal studies with transgenic mouse models failed due to the high mortality of the mouse embryos with abnormal function of NF-jB pathway or were biased due to compensatory molecular process activity.…”

Section: Figmentioning

confidence: 99%

l-Alpha Glycerylphosphorylcholine as a Potential Radioprotective Agent in Zebrafish Embryo Model

et al. 2016

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This work establishes the zebrafish embryo model for ionizing radiation (IR) modifier research and also evaluates the protective effect of L-alpha glycerylphosphorylcholine (GPC). Embryos were exposed to a single-fraction wholebody gamma irradiation (5, 10, 15, and 20 Gy) at different postfertilization time points and were serially assessed for viability and macro-and micromorphologic abnormalities. After toxicity evaluation, 194 lM of GPC was added for certain groups with 3-h incubation before the radiation. Nuclear factor kappa B (NF-jB) and interleukin-1b (IL-1b) expression changes were measured using quantitative real-time polymerase chain reaction. A higher sensitivity could be observed at earlier stages of the embryogenesis. The lethal dose (LD 50 ) for 6 hours postfertilization (hpf) embryos was 15 Gy and for 24 hpf was 20 Gy on day 7, respectively. GPC administration resulted in a significant improvement in both the distortion rate and survival of the 24 hpf embryos. Qualitative evaluation of the histological changes confirmed the protective effect of GPC. IL-1b and NF-jB overexpression due to 10 Gy irradiation was also reduced by GPC. GPC exhibited promising radioprotective effects in our zebrafish embryo model, decreasing the irradiationinduced morphological damage and lethality with significant reduction of IR-caused pro-inflammatory activation.

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Portrait of inflammatory response to ionizing radiation treatment

Cited by 234 publications

References 163 publications

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The melatonin immunomodulatory actions in radiotherapy

l-Alpha Glycerylphosphorylcholine as a Potential Radioprotective Agent in Zebrafish Embryo Model

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