Positive Correlation between Erythrocyte Levels of n–3 Polyunsaturated Fatty Acids and Bone Mass in Postmenopausal Korean Women with Osteoporosis

Moon, Hyoun-Jung; Kim, Tae-Hee; Byun, Dong Won; Park, Yongsoon

doi:10.1159/000337302

Cited by 38 publications

(33 citation statements)

References 59 publications

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“…Previously, we observed that the average erythrocyte levels of n-3 PUFA were approximately 10% among Koreans, which is similar to the Japanese rate but higher than in Western populations [20,21]. The Korean National Health and Nutrition Examination survey consistently reported that Korean adults consumed higher amounts of fish (50 g/day) than did Western populations [22].…”

Section: Introductionmentioning

confidence: 69%

The Association between n-3 Polyunsaturated Fatty Acid Levels in Erythrocytes and the Risk of Rheumatoid Arthritis in Korean Women

Lee

Park

2013

Ann Nutr Metab

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Background: Rheumatoid arthritis (RA) is one of the most common autoimmune diseases that result in chronic inflammation of the joints. n-3 polyunsaturated fatty acids (PUFAs) have been suggested to play a role in the pathogenesis and clinical course of RA. The purpose of the present study was to investigate whether erythrocyte levels of n-3 PUFA are associated with an increased risk of RA and whether this could potentially serve as an indicator of RA disease activity in Korean women. Methods: A total of 100 female RA patients and 100 healthy women were enrolled into this study. Erythrocyte fatty acid composition and RA disease activity were evaluated in all patients. Results: Erythrocyte levels of α-linolenic acid (ALA; 18:3n3), eicosapentaenoic acid (EPA; 20:5n3), and the omega-3 index [EPA + docosahexaenoic acid (DHA)] were significantly lower in RA patients than in healthy controls. Multivariable-adjusted regression analysis showed that the levels of ALA, EPA, and the ratio of EPA to arachidonic acid were negatively associated with the risk of RA after adjusting for body weight and smoking status. Additionally, the concentration of prostaglandin E₂ was significantly decreased with increased levels of erythrocyte DHA among RA patients. Conclusions: Erythrocyte levels of EPA and ALA were negatively associated with the risk of RA in Korean women, which may be related to eicosanoid metabolism.

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Section: Introductionmentioning

confidence: 69%

The Association between n-3 Polyunsaturated Fatty Acid Levels in Erythrocytes and the Risk of Rheumatoid Arthritis in Korean Women

Lee

Park

2013

Ann Nutr Metab

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“…Equally, promising results are now available regarding their positive effects on inflammatory diseases, cancer, and osteoporosis (Moon et al, 2012). The use of PNEC in cereal mixes, cereal bars, or bakery products would be a good alternative to provide high contents of oleic and linoleic acids, and also linolenic acid, and thus enhance the nutritional quality of foods.…”

Section: Quality Characteristics During Storagementioning

confidence: 99%

Characterization of pecan nut expeller cake and effect of storage on its microbiological and oxidative quality

et al. 2018

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SUMMARY:Pecan nut expeller cake (PNEC), a by-product of pecan oil extraction, was characterized and the effect of packaging and storage conditions was investigated. Samples were packaged under vacuum or in normal atmosphere and stored (10 or 20 ºC) for 12 months. Its composition, water and oil absorption, fatty acids profile, lipid oxidation (thiobarbituric acid reactive substances, TBARS), antioxidant activity [Diphenyl-1-(2,4,6-trinitrophenyl)hydrazyl] radical, DPPH• and [(2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid)] radical cation, ABTS•+ ), and microbiological quality were analyzed. PNEC showed high lipid and fiber contents (51.4 and 21.6 g/100g, respectively) with good water and oil absorption capacity. Vacuum storage at 10 ºC preserved antioxidant capacity (TBARS: malondialdehyde= 0.23 mg/kg, IC 50 DPPH = 9.0 mg/mL, and IC 50 ABTS = 21 mg/mL after one year storage). Extremely low mold and yeast levels were found in PNEC in low permeability vacuum packages, regardless of the storage temperature. Thus, PNEC could retain suitable quality attributes for up to 12 months using the right combination of packaging and temperature.KEYWORDS: Antioxidant capacity; Fatty acid profile; Pecan nut expeller cake; Storage; TBARS RESUMEN: Caracterización de la torta prensada de nuez de pecan y efecto del almacenamiento sobre su calidad microbiológica y oxidativa. La torta de prensada de nuez de pecan (PNEC), un sub-producto dela extracción de aceite de pecan, fue caracterizado y se investigó el efecto del embalaje y condiciones de almacenamiento. Las muestras fueron envasadas con y sin vacío y almacenadas (10 o 20ºC) durante 12 meses. Se analizó la composición, absorción de agua y aceite, perfiles de ácidos grasos, oxidación lipídica (sustancias reactivas al ácido tiobarbitúrico, TBARS), actividad antioxidante [radical (difenil-1-(2,4,6-trinitrofenil) hidracilo] DPPH• y catión radical [ácido (2,2′-azinobis-(3-etilbenzotiazolin-6-sulfónico)], ABTS•+ ) y calidad microbiológica. El PNEC mostró altos contenidos de lípidos y fibra (51.4 y 21.6 g/100g, respectivamente) con buenas capacidades de absorción de agua y aceite. El almacenamiento bajo vacío a 10ºC preservó la capacidad antioxidante (TBARS: malondialdehído, MDA = 0.23 mg/kg, IC 50 DPPH = 9.0 mg/mL, y IC 50 ABTS = 21 mg/mL luego de un año de almacenamiento). Los recuentos de hongos y levaduras fueron extremadamente bajos en los tratamientos con vacío y envases de baja permeabilidad, para ambas temperaturas. Por lo tanto, el PNE pudo retener adecuados atributos de calidad hasta 12 meses empleando la adecuada combinación de envase y temperatura.

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“…Several PUFA have shown to affect bone cells via different cellular signaling pathways or growth factors, thereby modulating bone formation, reabsorption and density in different animals, including humans (Jarvinen et al 2012;Moon et al 2012;Rahman et al 2009;Salari et al 2008). On the other hand, fatty acids play a central role in the induction of mesenchymal stromal cells (MSC) to adipocyte differentiation, as well as in adipose tissue hypertrophy, because they have the ability to activate the peroxisome proliferator-activated receptor gamma (PPARc), which is a transcription factor inducing adipogenesis (Lopez et al 2003;Shillabeer and Lau 1994).…”

Section: Introductionmentioning

confidence: 99%

Effects of arachidonic acid on the concentration of hydroxyeicosatetraenoic acids in culture media of mesenchymal stromal cells differentiating into adipocytes or osteoblasts

et al. 2013

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Metabolites derived from the polyunsaturated fatty acids (PUFA) may modulate the mesenchymal stromal cell (MSC) differentiation. Such cells can differentiate into different cellular types, including adipocytes and osteoblasts. Aging favors the bone marrow MSC differentiation toward the former, causing a loss of bone density associated with pathologies like osteoporosis. The omega-6 arachidonic acid (AA) favors MSC adipogenesis to a greater extent than omega-3 eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). In this work, we study the joint action of both PUFA. Thus, not induced and induced to adipocyte or osteoblast MSC were treated with 20 lM of each PUFA (either AA, AA ? DHA or AA ? EPA). The expression of osteogenic and adipogenic molecular markers, the alox15b lipoxygenase gene expression and the 5-, 8-, 11-, 12-and 15-hydroxyeicosatetraenoic acids (HETE) derived from the AA metabolism in the culture media were determined. The results show that the adipogenesis induction of AA is not suppressed by the joint presence of EPA and DHA. In fact, both increased the adipogenic effect of AA on MSC differentiated into osteoblasts. The different HETE concentrations increased in cultures supplemented with AA, albeit such concentrations were lower in the cultures induced to differentiate, mainly at day 21 after the induction. Furthermore, the reduction in the HETE concentration was correlated with a higher expression of the alox15b gene. These results highlight the PUFA metabolism differences between uninduced and induced MSC to differentiate into adipocytes and osteoblasts, besides the relevant role of the lipoxygenase gene expression in adipogenesis induction.

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Positive Correlation between Erythrocyte Levels of n–3 Polyunsaturated Fatty Acids and Bone Mass in Postmenopausal Korean Women with Osteoporosis

Cited by 38 publications

References 59 publications

The Association between n-3 Polyunsaturated Fatty Acid Levels in Erythrocytes and the Risk of Rheumatoid Arthritis in Korean Women

The Association between n-3 Polyunsaturated Fatty Acid Levels in Erythrocytes and the Risk of Rheumatoid Arthritis in Korean Women

Characterization of pecan nut expeller cake and effect of storage on its microbiological and oxidative quality

Effects of arachidonic acid on the concentration of hydroxyeicosatetraenoic acids in culture media of mesenchymal stromal cells differentiating into adipocytes or osteoblasts

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