Positron emission tomography in spinal infections

Georgakopoulos, Alexandros; Pneumaticos, Spiros G.; Sipsas, Nikolaos V.; Chatziioannou, Sofia

doi:10.1016/j.clinimag.2015.04.002

Cited by 9 publications

(6 citation statements)

References 42 publications

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“… 34 Positron emission tomography might be an alternative in undetermined cases following the prior mentioned diagnostical tools. 35 In undetermined cases, CT guided biopsy might offer a possible solution. 36 Alternative or additional diagnosis, including aseptic implant loosening, spinal tissue infection without implant involvement and skin infections like erysipelas should be excluded at any stage.…”

Section: Resultsmentioning

confidence: 99%

Postoperative Spinal Implant Infections (PSII)—A Systematic Review: What Do We Know So Far and What is Critical About It?

Karczewski

Schnake

Osterhoff

et al. 2021

Global Spine Journal

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Study Design: Systematic review. Objectives: Postoperative spinal implant infections (PSII) are an increasing challenge in the daily clinical routine. This review summarizes existing knowledge in the field of PSII, including definitions, epidemiology, classifications, risk factors, pathogenesis, symptoms, diagnosis, and treatment. Methods: A systematic review was performed using a structured PubMed analysis, based on the PRISMA criteria. The search terminology was set as: “spinal implant associated infection OR spinal implant infection OR spinal instrumentation infection OR peri spinal implant infection.” PubMed search was limited to the categories randomized controlled trials (RCT), clinical trials, meta-analysis and (systematic) reviews, whereas case reports were excluded. Studies from January 2000 to December 2020 were considered eligible. A total of 572 studies were identified, 82 references included for qualitative synthesis, and 19 for detailed sub analysis (12 meta-analysis, 7 prospective RCT). Results: Structural problems in the field of PSII were revealed, including (1) limited level of evidence in clinical studies (missing prospective RCT, metanalyzes), (2) small patient numbers, (3) missing standardized definitions, (4) heterogeneity in patient groups, and (5) redundancy in cited literature. Conclusion: Evidence-based knowledge about spinal implant-associated infections is lacking. All involved medical fields should come together to define the term PSII and to combine their approaches toward research, training, and patient care.

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Section: Resultsmentioning

confidence: 99%

Postoperative Spinal Implant Infections (PSII)—A Systematic Review: What Do We Know So Far and What is Critical About It?

Karczewski

Schnake

Osterhoff

et al. 2021

Global Spine Journal

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“…FDG is an unspecific tracer that reflects high glucose metabolism [2]. It has a fast distribution in the body, even in tissues with a low perfusion.…”

Section: Discussionmentioning

confidence: 99%

“…Positron Emission Tomography and Computed Tomography (FDG-PET/CT) as a highly sensitive method in diagnosing spinal infections [2][3][4]. The technique J ournal of…”

Section: Several Studies Have Proved the Value Of 18f-fluorodeoxyglucmentioning

confidence: 99%

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FDG-PET/CT Limitations in the Diagnosis of Spinal Implant Infection

Bolander¹,

Åkerlund²,

Axelsson³

2019

J Med Imaging Case Rep

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“…Published data indicate that [ 18 F]FDG-PET/CT is superior to 67 Ga for the diagnosis of spinal infection and paraspinal soft tissue infection [82], and should be used in selected cases as an alternative to MRI [3,61,[94][95][96][97][98][99][100][101][102][103][104][105][106][107][108][109]. All studies in which a comparison between MRI and [ 18 F]FDG-PET/CT was performed have shown that a combination of the two techniques detects spinal infection in 100% of patients [102,110,111].…”

Section: Influence Of Medicationmentioning

confidence: 99%

Joint EANM/ESNR and ESCMID-endorsed consensus document for the diagnosis of spine infection (spondylodiscitis) in adults

Lazzeri

Bozzao

Cataldo

et al. 2019

Eur J Nucl Med Mol Imaging

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Purpose Diagnosis of spondylodiscitis (SD) may be challenging due to the nonspecific clinical and laboratory findings and the need to perform various diagnostic tests including serologic, imaging, and microbiological examinations. Homogeneous management of SD diagnosis through international, multidisciplinary guidance would improve the sensitivity of diagnosis and lead to better patient outcome. Methods An expert specialist team, comprising nuclear medicine physicians appointed by the European Association of Nuclear Medicine (EANM), neuroradiologists appointed by the European Society of Neuroradiology (ESNR), and infectious diseases specialists appointed by the European Society of Clinical Microbiology and Infectious Diseases (ESCMID), reviewed the literature from January 2006 to December 2015 and proposed 20 consensus statements in answer to clinical questions regarding SD diagnosis. The statements were graded by level of evidence level according to the 2011 Oxford Centre for Evidence-based Medicine criteria and included in this consensus document for the diagnosis of SD in adults. The consensus statements are the result of literature review according to PICO (P:population/patients, I:intervention/indicator, C:comparator/control, O:outcome) criteria. Evidence-based recommendations on the management of adult patients with SD, with particular attention to radiologic and nuclear medicine diagnosis, were proposed after a systematic review of the literature in the areas of nuclear medicine, radiology, infectious diseases, and microbiology. Results A diagnostic flow chart was developed based on the 20 consensus statements, scored by level of evidence according to the Oxford Centre for Evidence-based Medicine criteria. Conclusions This consensus document was developed with a final diagnostic flow chart for SD diagnosis as an aid for professionals in many fields, especially nuclear medicine physicians, radiologists, and orthopaedic and infectious diseases specialists.

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Positron emission tomography in spinal infections

Cited by 9 publications

References 42 publications

Postoperative Spinal Implant Infections (PSII)—A Systematic Review: What Do We Know So Far and What is Critical About It?

Postoperative Spinal Implant Infections (PSII)—A Systematic Review: What Do We Know So Far and What is Critical About It?

FDG-PET/CT Limitations in the Diagnosis of Spinal Implant Infection

Joint EANM/ESNR and ESCMID-endorsed consensus document for the diagnosis of spine infection (spondylodiscitis) in adults

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