Possible applications of salvianolic acid B against different cancers

Abstract

Cancer is the second death causing disease worldwide after cardiovascular abnormalities. The difficulty in treating tumor cells with more precise targeted interventions and recurrence of cancer after treatment may pose great difficulty in developing sustainable therapeutic regimens. These limitations have prompted the need to explore several compounds with ability to cease tumor growth while at the same time induce apoptosis of tumor cells. Several studies have emphasized the use of natural compounds as antitumor agents due to their high efficacy against cancer cells and low toxicity in normal cells. Salvianolic acid B (SAB), a naturally occurring phenolic compound extracted from the radix of Chinese herb Salvia miltiorrhiza can induce apoptosis in different types of tumor cells. It can be used to treat cardiovascular and neurodegenerative disorders, hepatic fibrosis, and cancers. Several studies have shown that SAB can mitigate tumorigenesis by modulating MAPK, PI3K/AKT, and NF-ĸB signaling pathways. It also sensitizes the tumor cells to different anti-cancer agents by reversing the multi-drug resistance mechanisms found in tumor cells. This review summarizes the studies showing antitumor potential of SAB in different types of cancer cell lines, animal models and highlights the possible mechanisms through which SAB can induce apoptosis, inhibit growth and metastasis in tumor cells. Moreover, the possible role of nano-technological approaches to induce targeted delivery of SAB to eradicate tumor cells has been also discussed.

Salvianolic Acid B Reduces Oxidative Stress to Promote Hair-Growth in Mice, Human Hair Follicles and Dermal Papilla Cells

“…Danshen, a traditional Chinese medicine, contains SAB, which pharmacological studies have identified as having antioxidative, anti-inflammatory, autophagy-promoting, anti-fibrotic, and angiogenic properties. 11 These attributes suggest that SAB could potentially enhance hair growth and mitigate hair loss. However, its role in protecting hair follicles from oxidative stress remains under-explored.…”

“…Supporting our observations, several studies have documented SAB's antitumor efficacy, highlighting its role in growth inhibition and apoptosis across various tumor cell types. 8,11,16 Studies indicate that environmental stressors like hydrogen peroxide (H2O2), ultraviolet radiation, and DHT contribute to damage in dermal papilla cells (DPCs), ultimately leading to hair loss. SAB demonstrates a protective effect against oxidative stress-induced damage in hair follicle cells, effectively maintaining hair growth promoters amidst these stress factors.…”

Salviae miltiorrhiza against human lung cancer: A review of its mechanism (Review)

“…A number of studies have shown that different parts and different components of S. miltiorrhiza have effects against different types of non-small cell lung cancer (NSCLC) and the same component against the same type of lung cancer cells may involve multiple mechanisms of action, such as inhibiting cell proliferation, promoting cell apoptosis, inducing cell autophagy, regulating immune-related, fighting tumor angiogenesis and inhibiting cell migration and invasion ( 47 , 49 , 52 , 53 ) ( Fig. 2 ).…”

Effective treatment of intractable diseases using nanoparticles to interfere with vascular supply and angiogenic process

“…A naturally occurring phenolic substance with antioxidant effects is salvianolic acid B (SAB). On the other hand, the limited applicability of hydrophilic SAB may be due to its low bioavailability [ 244 ]. Boronic ester-based NPs can act as ROS-responsive vehicles that can quickly and selectively release drugs at the site of injured tissue [ 18 ].…”