The p-type networks are designed with the help of CVNET at topo group Cluj and also given support by nano studio. Such networks develop new p-type surfaces and also represent the decorations of the surfaces. This patched network is designed by two repeated units. The first one is triphenylene having a Z-pen formula and the second one is triphenylene with A-phe. Furthermore, these decorations are acquired as the result of map operations represented in the CVNET software, while its assembling is conducted with the help of the nano studio program. In the literature, its topology is discussed by Omega polynomials which is an applied graph theory topic. Another most applied topic of graph theory is known as the resolvability parameter. So this article studied the resolvability parameters of patched networks, such as metric dimension, and edge metric dimension. These parameters are defined as a resolving set is a subset of vertices of a graph with a condition that each vertex of that graph has a unique code or representation with respect to the chosen subset. Its minimum cardinality is known as metric dimension, while the edge metric dimension is defined by the minimum count of members in the edge resolving set and this set is defined as according to a chosen subset each edge of a graph has unique representations, then this set is known as edge resolving set. A resolving set is a subset of vertices of a graph with a condition that each edge of that graph has a unique code or representation with respect to the chosen subset. It is minimum cardinality is known as the edge metric dimension.

Cancer is the second death causing disease worldwide after cardiovascular abnormalities. The difficulty in treating tumor cells with more precise targeted interventions and recurrence of cancer after treatment may pose great difficulty in developing sustainable therapeutic regimens. These limitations have prompted the need to explore several compounds with ability to cease tumor growth while at the same time induce apoptosis of tumor cells. Several studies have emphasized the use of natural compounds as antitumor agents due to their high efficacy against cancer cells and low toxicity in normal cells. Salvianolic acid B (SAB), a naturally occurring phenolic compound extracted from the radix of Chinese herb Salvia miltiorrhiza can induce apoptosis in different types of tumor cells. It can be used to treat cardiovascular and neurodegenerative disorders, hepatic fibrosis, and cancers. Several studies have shown that SAB can mitigate tumorigenesis by modulating MAPK, PI3K/AKT, and NF-ĸB signaling pathways. It also sensitizes the tumor cells to different anti-cancer agents by reversing the multi-drug resistance mechanisms found in tumor cells. This review summarizes the studies showing antitumor potential of SAB in different types of cancer cell lines, animal models and highlights the possible mechanisms through which SAB can induce apoptosis, inhibit growth and metastasis in tumor cells. Moreover, the possible role of nano-technological approaches to induce targeted delivery of SAB to eradicate tumor cells has been also discussed.

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