Possible association between serotonin transporter promoter region polymorphism and impulsivity in Koreans

Lee, Jong-Hun; Kim, Hong-Tae; Hyun, Dae Sung

doi:10.1016/s0165-1781(03)00065-9

Cited by 41 publications

(28 citation statements)

References 35 publications

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“…However, another study has found no association between antisocial alcoholism and 5-HTTLPR polymorphism [9], while an investigation of AfricanAmerican cocaine-dependent individuals has shown no evidence of a relationship between the 5-HTTLPR polymorphism and impulsive-aggressive traits [10]. Furthermore, although our finding is similar to those of most western reports [6][7][8], it is at odds with a Korean report that demonstrated greater prevalence of the L allele in the prisoner group [16]. There are several possible explanations for this discrepancy.…”

Section: Discussioncontrasting

confidence: 84%

Possible Association between Serotonin Transporter Promoter Region Polymorphism and Extremely Violent Crime in Chinese Males

et al. 2004

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The neurotransmitter, serotonin, has been implicated in aggressive behavior. The serotonin transporter (5-HTT), which reuptakes serotonin into the nerve terminal, plays a critical role in the regulation of serotonergic function. Previous western reports have demonstrated that the low-activity short (S) allele of the 5-HTT gene-linked polymorphic-region (5-HTTLPR) polymorphism is associated with aggressive behavior and associated personality traits. In the present study, we investigated this 5-HTTLPR genetic polymorphism in a group of Chinese males who had been convicted for extremely violent crime (n = 135) and a normal control group (n = 111). The proportion of S-allele carriers was significantly higher in the criminal group than in the controls (p = 0.006). A significant association was not demonstrated for the relationship between the 5-HTTLPR polymorphism and antisocial personality disorder, substance abuse or alcohol abuse in the criminal group. Our findings demonstrate that carriage of the low-activity S allele is associated with extremely violent criminal behavior in Chinese males, and suggests that the 5-HTT may be implicated in the mechanisms underlying violent behaviors.

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Section: Discussioncontrasting

confidence: 84%

Possible Association between Serotonin Transporter Promoter Region Polymorphism and Extremely Violent Crime in Chinese Males

et al. 2004

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“…Studies have shown that the 5-HTTLPR short (S) allele is associated with emotion and cognition (Lee et al, 2003). Whether the pathogenesis and predisposing factors for PSD are the same as those for depression itself has been a research focus in recent years.…”

Section: Discussionmentioning

confidence: 99%

Relationship between 5-HTTLPR polymorphism and post-stroke depression

Guo¹,

Zhang²,

Mu³

et al. 2016

Genet. Mol. Res.

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“…4 Disturbances in serotonin transmission are the most frequently reported neurobiological substrates. 2,5,6 The serotonin transporter (5-HTT) gene, located at 17q11.1-q12, plays a central role in the regulation of the 5-HT synaptic function and is considered to be a promising candidate for various psychiatric disorders, including suicidal behavior.…”

Section: Introductionmentioning

confidence: 99%

Meta-analysis supports association between serotonin transporter (5-HTT) and suicidal behavior

2006

Mol Psychiatry

186

102

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Suicidal behavior, which ranks among the top 10 causes of death worldwide, is an important public-health problem and a psychiatric disorder, which has been the subject of considerable study. Studies have shown association between the serotonin transporter (5-HTT) gene and suicidal behavior, although a proportion of alternative studies have produced contrary results both in terms of positive and negative findings, possibly reflecting inadequate statistical power and the use of different populations. Using the cumulative data from recent years in both European and, more particularly, Asian populations, this updated meta-analysis seeks to examine whether the aggregate data provide evidence of statistical significance, and to clarify the contradictory findings suggested by previous studies. It covers all published studies using multiple research methods up to January 2006. Compared with a previous meta-analysis, which found no association between the 5-HTTLPR polymorphism and suicidal behavior (P = 0.38), the current results (39 studies) suggest a significant association with a P-value of 0.0068 (overall odds ratio = 0.88 (0.8,0.97)), and supports the involvement of the brain 5-HTT in the pathogenesis of suicidal behavior.

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Possible association between serotonin transporter promoter region polymorphism and impulsivity in Koreans

Cited by 41 publications

References 35 publications

Possible Association between Serotonin Transporter Promoter Region Polymorphism and Extremely Violent Crime in Chinese Males

Possible Association between Serotonin Transporter Promoter Region Polymorphism and Extremely Violent Crime in Chinese Males

Relationship between 5-HTTLPR polymorphism and post-stroke depression

Meta-analysis supports association between serotonin transporter (5-HTT) and suicidal behavior

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