Possible contribution of interferon-α to febrile seizures in influenza

Masuyama, Tatsuo; Matsuo, Muneaki; Ichimaru, Tomohiro; Ishii, Kiyohisa; Tsuchiya, Katsunori; Hamasaki, Yuhei

doi:10.1016/s0887-8994(02)00452-6

Cited by 27 publications

(12 citation statements)

References 20 publications

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“…Moreover, IL-6 levels in febrile seizure patients were much higher than in afebrile seizure attack patients. Higher IL-6 and IFN-α levels have been reported in patients with influenza-associated febrile seizures compared to those without febrile seizures [3,48]. These findings, with our results, may support the pro-convulsant action of IL-6 in febrile seizures.…”

Section: Discussionsupporting

confidence: 87%

Increased levels of HMGB1 and pro-inflammatory cytokines in children with febrile seizures

Choi

Min

Shin

2011

J Neuroinflammation

145

105

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ObjectiveFebrile seizures are the most common form of childhood seizures. Fever is induced by pro-inflammatory cytokines during infection, and pro-inflammatory cytokines may trigger the development of febrile seizures. In order to determine whether active inflammation, including high mobility group box-1 (HMGB1) and pro-inflammatory cytokines, occurs in children with febrile seizures or epilepsy, we analyzed cytokine profiles of patients with febrile seizures or epilepsy.MethodsForty-one febrile seizure patients who visited the emergency department of Seoul National University Boramae Hospital from June 2008 to May 2009 were included in this study. Blood was obtained from the febrile seizure child patients within 30 minutes of the time of the seizure; subsequently, serum cytokine assays were performed. Control samples were collected from children with febrile illness without convulsion (N = 41) and similarly analyzed. Serum samples from afebrile status epilepticus attacks in intractable epilepsy children (N = 12), afebrile seizure attacks in generalized epilepsy with febrile seizure plus (GEFSP) children (N = 6), and afebrile non-epileptic controls (N = 7) were also analyzed.ResultsSerum HMGB1 and IL-1β levels were significantly higher in febrile seizure patients than in fever only controls (p < 0.05). Serum IL-6 levels were significantly higher in typical febrile seizures than in fever only controls (p < 0.05). Serum IL-1β levels were significantly higher in status epilepticus attacks in intractable epilepsy patients than in fever only controls (p < 0.05). Serum levels of IL-1β were significantly correlated with levels of HMGB1, IL-6, and TNF-α (p < 0.05).ConclusionsHMGB1 and pro-inflammatory cytokines were significantly higher in febrile seizure children. Although it is not possible to infer causality from descriptive human studies, our data suggest that HMGB1 and the cytokine network may contribute to the generation of febrile seizures in children. There may be a potential role for anti-inflammatory therapy targeting cytokines and HMGB1 in preventing or limiting febrile seizures or subsequent epileptogenesis in the vulnerable, developing nervous system of children.

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Section: Discussionsupporting

confidence: 87%

Increased levels of HMGB1 and pro-inflammatory cytokines in children with febrile seizures

Choi

Min

Shin

2011

J Neuroinflammation

145

105

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“…Some related articles were excluded because of unvalued data (Dias De Sousa et al, 2012), lack of specific values (mean ± SD) ( Masuyama et al, 2002;Virta et al, 2002b;Ichiyama et al, 2004Ichiyama et al, , 2008Ichiyama et al, , 2009Stoeck et al, 2006;Yamanaka et al, 2006Yamanaka et al, , 2010Fukumoto et al, 2007;Sinha et al, 2008 Asano et al, 2010;Blyth et al, 2011;Mathieu et al, 2011;Haberlandt et al, 2013), lack of a control group without any neurological complications interfered with immunological response or using baseline references (Billiau et al, 2007;Alapirtti et al, 2009;Bauer et al, 2009;Li et al, 2013;Uludag et al, 2013), concomitant disorders in epileptic cases [e.g., depression (Lehtimäki et al, 2008) and neurocysticercosis (Evans et al, 1998)], concomitant disorders in the control group (e.g., encephalitis) (Ichiyama et al, 1998;Hu et al, 2014), and replicated data (Peltola et al, 2002). Some abstracts seemed to be related, but full-text was not available to make sure if they met the inclusion criteria or not (Ling et al, 1993;Kawakami et al, 1999b;Haspolat et al, 2002;Ganor et al, 2005;Makis et al, 2005;Lehtimäki et al, 2010;Lukaszewicz et al, 2010;Majoie et al, 2010;Mine et al, 2013).…”

Section: Resultsmentioning

confidence: 99%

Proinflammatory and anti-inflammatory cytokines in febrile seizures and epilepsy: systematic review and meta-analysis

Saghazadeh

Gharedaghi

Meysamie

et al. 2014

Reviews in the Neurosciences

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“…Influenza-associated febrile seizures are often prolonged and complex, independent of the severity of the viral infection 45. IFN-α and IL-6 are significantly higher in patients with febrile seizures compared to those without 46. This finding suggests that influenza-associated febrile seizures may be the result of systemic immune responses, and that IFN-α and IL-6 are involved in the pathogenesis of febrile seizures (in influenza, at least).…”

Section: Inflammation Is Implicated In Childhood Neurological Diseasementioning

confidence: 99%

Role of Brain Inflammation in Epileptogenesis

2008

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Inflammation is known to participate in the mediation of a growing number of acute and chronic neurological disorders. Even so, the involvement of inflammation in the pathogenesis of epilepsy and seizure-induced brain damage has only recently been appreciated. Inflammatory processes, including activation of microglia and astrocytes and production of proinflammatory cytokines and related molecules, have been described in human epilepsy patients as well as in experimental models of epilepsy. For many decades, a functional role for brain inflammation has been implied by the effective use of anti-inflammatory treatments, such as steroids, in treating intractable pediatric epilepsy of diverse causes. Conversely, common pediatric infectious or autoimmune diseases are often accompanied by seizures during the course of illness. In addition, genetic susceptibility to inflammation correlated with an increased risk of epilepsy. Mounting evidence thus supports the hypothesis that inflammation may contribute to epileptogenesis and cause neuronal injury in epilepsy. We provide an overview of the current knowledge that implicates brain inflammation as a common predisposing factor in epilepsy, particularly childhood epilepsy.

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Possible contribution of interferon-α to febrile seizures in influenza

Cited by 27 publications

References 20 publications

Increased levels of HMGB1 and pro-inflammatory cytokines in children with febrile seizures

Increased levels of HMGB1 and pro-inflammatory cytokines in children with febrile seizures

Proinflammatory and anti-inflammatory cytokines in febrile seizures and epilepsy: systematic review and meta-analysis

Role of Brain Inflammation in Epileptogenesis

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