Proinflammatory and anti-inflammatory cytokines in febrile seizures and epilepsy: systematic review and meta-analysis

Interleukin-1β/Interleukin10 Ratio Produced by Monocytes as a Biomarker of Neuroinflammation in Autism

“…ASD subjects with deviated ratios were found to have higher frequencies of non-IgE mediated food allergy (NFA) and seizure disorders than in those with normal ratios as summarized in Table 4. These results are intriguing, given the well-described role of IL-1β in febrile seizures and rodent models of seizures [35,38]. Our results also indicate that ASD subjects with the deviated IL-1β/IL-10 ratios may represent a subset of ASD subjects in whom dysregulated innate immune responses play a role in alternations in the neuro-immune network ( Figure 6).…”

“…However, IL-1β also plays a crucial role in brain inflammation and subsequent brain pathology in multiple neurological conditions. In febrile seizures, IL-1β has been shown to play a major role [35]. Certain auto-inflammatory syndromes are caused by gene mutations that result in dysregulated, excessive IL-1β production 36.…”

Immuno-epileptology

“…There may be shared genetic contribution between febrile and epileptic seizures as described in detail elsewhere [9,14]. Genes that have been shown to be associated with both febrile and epileptic seizures include SCN1A, IL-1β, CHRNA4, and GABRG2.…”

Hva skyldes feberkramper?

“…Hos barn med feberkramper er det funnet økte konsentrasjoner av proinflammatoriske cytokiner, fremfor alt IL-1 og TNF, i både serum og spinalvaesken sammenlignet med febrile barn uten kramper (6). En teori går ut på at høy temperatur i hjernen fører til økt frigjøring av IL-1 som bindes til spe-sifikke reseptorer på nevroner, blant annet i hippocampus.…”

“…En teori går ut på at høy temperatur i hjernen fører til økt frigjøring av IL-1 som bindes til spe-sifikke reseptorer på nevroner, blant annet i hippocampus. Dette kan gi økt nevronal eksitabilitet med økt anfallstendens (6)…”