2020
DOI: 10.1111/jre.12774
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Possible function of GDNF and Schwann cells in wound healing of periodontal tissue

Abstract: Objective: The purpose of this study was to evaluate the function of Schwann cells in wound healing of periodontal tissue. Background: In our previous study, glial cell line-derived neurotrophic factor (GDNF) promoted the migration of human periodontal ligament (PDL) cells and that GDNF expression increased in wounded periodontal tissue. GDNF reportedly induces the migration of Schwann cell precursors. Schwann cells play a crucial role in the regeneration of peripheral tissues, including bone tissue. However, … Show more

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Cited by 11 publications
(8 citation statements)
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“…Nerves and various regulatory factors form a complex network of interactions ( Chéret et al, 2014 ), and neurotrophic factors are considered a possible factor in skin wound healing. Subsequently, we detected the expression of neural factors in fibroblasts by polymerase chain reaction ( Itoyama et al, 2020 ). To further test our hypothesis, we used animal models to explore the role of MSC-Exo.…”
Section: Discussionmentioning
confidence: 99%
“…Nerves and various regulatory factors form a complex network of interactions ( Chéret et al, 2014 ), and neurotrophic factors are considered a possible factor in skin wound healing. Subsequently, we detected the expression of neural factors in fibroblasts by polymerase chain reaction ( Itoyama et al, 2020 ). To further test our hypothesis, we used animal models to explore the role of MSC-Exo.…”
Section: Discussionmentioning
confidence: 99%
“…Additionally, DCN controls inflammation by regulating the production of proinflammatory cytokines [ 16 ]. Using our animal model, we previously reported an increased expression of IL-1β around wounded PDL tissue and the alveolar bone from days 1 to 3 after surgery [ 33 ] and the emergence of Schwann cells, which are indispensable for tissue formation and regeneration, 7 days after surgery [ 41 ]. These findings indicate that the inflammation stage occurs for approximately 3 days after surgery and that tissue formation starts from approximately 7 days after surgery.…”
Section: Discussionmentioning
confidence: 99%
“…Additionally, Schwann cells perform a critical function in bone tissue repair ( Figure 2 C) [ 142 ]. Schwann cells are found in damaged periodontal tissue, indicating that the cells play an essential role in wound healing, particularly in alveolar bone tissue [ 143 ]. Nerve-associated SCPs dedifferentiate after the distal digit of a rat is removed.…”
Section: The Effect Of the Nervous System On Bonementioning
confidence: 99%