Possible healing effects of Salvadora persica extract (MISWAK) and laser therapy in a rabbit model of a caustic-induced tongue ulcers: histological, immunohistochemical and biochemical study

Faruk, Eman Mohamed; Nafea, Ola Elsayed; Fouad, Hanan; Ebrahim, Usama Fouad Ahmed; Hasan, Rehab A.

doi:10.1007/s10735-020-09884-7

Cited by 8 publications

(16 citation statements)

References 33 publications

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Section: Regenerative and Stem Cell Modulationmentioning

confidence: 99%

“…In recent years, numerous studies have begun to examine the therapeutic properties of SP and its bioactive constituents in a variety of medical fields, as well as the possible roles it could play in the future as part of clinical therapies or disease prevention measures [ 46 , 51 , 52 ].…”

Section: Salvadora Persica As a Therapeutic Agentmentioning

confidence: 99%

“…[ 31 , 120 , 121 ]. Among these studies, SP demonstrated a variety of effects that may influence periodontal therapy and play a role in improved regeneration and healing [ 51 , 62 , 67 , 122 , 123 ]. As elucidated in the studies [ 67 ], SP could activate transforming growth factor-β1 expression, promoting regenerative and stem cell functions, including self-renewal and differentiation, adhesion, proliferation and migration, angiogenesis, as well as production of extracellular matrix components [ 67 , 124 ].…”

Section: Modes Of Action Of Salvadora Persica As Potential Adjuncts During Periodontal Therapy and In Periodontitis-asmentioning

confidence: 99%

“…SP was correspondingly able to increase MSC and fibroblast proliferation and viability [ 62 , 63 ], besides an inhibition of collagen degradation [ 123 ], a chief factor of periodontal destruction [ 125 ]. Other investigations reported the significantly augmented therapeutic potential and healing capacity after administration of SP extract to the damaged sites [ 46 , 51 ]. Such findings suggest that SP has a high regenerative accelerating potential when used in conjunction with periodontal therapy.…”

Section: Modes Of Action Of Salvadora Persica As Potential Adjuncts During Periodontal Therapy and In Periodontitis-asmentioning

confidence: 99%

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Salvadora persica: Nature’s Gift for Periodontal Health

Mekhemar

Geib²,

Kumar

et al. 2021

Antioxidants

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Salvadora persica (SP) extract, displays very valuable biotherapeutic capacities such as antimicrobial, antioxidant, antiparasitic and anti-inflammatory effects. Numerous investigations have studied the pharmacologic actions of SP in oral disease therapies but its promising outcomes in periodontal health and treatment are not yet entirely described. The current study has been planned to analyze the reported effects of SP as a support to periodontal therapy to indorse regeneration and healing. In consort with clinical trials, in vitro investigations show the advantageous outcomes of SP adjunctive to periodontal treatment. Yet, comprehensive supplementary preclinical and clinical investigations at molecular and cellular levels are indispensable to reveal the exact therapeutic mechanisms of SP and its elements for periodontal health and therapy.

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Section: Regenerative and Stem Cell Modulationmentioning

confidence: 99%

Section: Salvadora Persica As a Therapeutic Agentmentioning

confidence: 99%

Section: Modes Of Action Of Salvadora Persica As Potential Adjuncts During Periodontal Therapy and In Periodontitis-asmentioning

confidence: 99%

Section: Modes Of Action Of Salvadora Persica As Potential Adjuncts During Periodontal Therapy and In Periodontitis-asmentioning

confidence: 99%

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Salvadora persica: Nature’s Gift for Periodontal Health

Mekhemar

Geib²,

Kumar

et al. 2021

Antioxidants

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“…Recently a study by ( Faruk et al, 2020 ) evaluated the healing effects of topical S. persica (SP) extract, low-level laser (LLL) and high-level laser (HLL) therapies in a rabbit model of caustic-induced tongue ulcers. They found that topical SP extract, LLL and HLL were equally effective therapies against caustics-induced tongue ulcers.…”

Section: Health Benefits Of the Plant And Its Extractsmentioning

confidence: 99%

Salvadora persica L.: Toothbrush tree with health benefits and industrial applications – An updated evidence-based review

Farag

Abdel‐Mageed

Gamal

et al. 2021

Saudi Pharmaceutical Journal

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Salvadora persica L. is also known as Arak (in Arabic) and Peelu (in Urdu). Its frequent use as a toothbrush (miswak) is highly recommended by Prophet Muhammad. With a long history in folk medicine for centuries, S. persica was used in oral hygiene, food, cosmetics, fuel, and even as a medicine. Previous phytochemical investigation of its different parts afforded different classes of secondary metabolites such as flavonoids, glycosides, sterols, terpenes, carbohydrates and alkaloids. Organic sulfur-containing compounds and elemental sulfur are also present. In addition, there is a huge research on its biological potentials and industrial applications. Many pharmacological activities were reported experimentally, including antimicrobial, antioxidant, analgesic, anthelmintic, anti-inflammatory, antiulcer, sedative, anticonvulsant, anti-osteoporosis, antidiabetic, hypo-lipidemic, in addition to wound-healing, antidepressant and antitumor activities. Recently, a possible activity against COVID-19 protease was documented by molecular docking. This review tries to provide a recent detailed documentation of folk and modern uses of S. persica, focusing on the possible relations between its chemical constituents, pharmacological properties, and industrial applications. Moreover, a brief about recent analytical and validation methods for the major antimicrobial component is reported.

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