Possible influence of vitamin D on male reproduction

Boisen, Ida Marie; Hansen, Lasse Bøllehuus; Mortensen, Li Juel; Lanske, Beate; Juul, Anders; Jensen, Martin Blomberg

doi:10.1016/j.jsbmb.2016.09.023

Cited by 71 publications

(61 citation statements)

References 76 publications

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“…Prolactin receptors have been found in Leydig and Sertoli cells in male testes, and high serum PRL levels reduce spermatogenesis, sperm motility and quality by reducing the pulsatile release of FSH, LH and testosterone (Blomberg et al, ; Boisen et al, ; Zhu et al, ). In our study, serum PRL levels were significantly elevated in the infertile groups than in the fertile group.…”

Section: Discussionmentioning

confidence: 99%

“…Some studies have shown an association and positive correlation between serum 25-OH VD levels and sperm parameters, especially sperm motility (Blomberg et al, 2016;Yang et al, 2012), while other studies did not confirm this link (Ramlau-Hansen, Moeller, Bonde, Olsen, & Thulstrup, 2011;Zhu et al, 2016). In studies on rats, there is evidence that serum 25-OH VD deficiency slows down spermatogenesis and decreases the fertilisation capacity of sperm, due to degenerative changes in the testes, and that fertility returns with vitamin D replacement therapy (Boisen et al, 2017;Lerchbaum & Obermayer-Pietsch, 2012). In our study, in keeping with previous studies, a significant positive correlation was noted between serum 25-OH VD levels and sperm motility.…”

Section: Discussionmentioning

confidence: 99%

“…Vitamin D, considered a steroid prohormone rather than a classic vitamin, take part a crucial role in calcium and phosphate homeostasis (Boisen et al, 2017;Lerchbaum & Obermayer-Pietsch, 2012). The metabolic pathway of vitamin D is strictly regulated, via 1 α hydroxylase enzyme, by parathormone, calcitonin, calcium and sex steroids (Hoenderop & Bindels, 2005).…”

Section: Introductionmentioning

confidence: 99%

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Investigation of serum vitamin D and ischaemia‐modified albumin levels in infertile Turkish men

İnal¹,

İnal²,

Mermer³

et al. 2020

Andrologia

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Our aim was to explore the existence of a possible relationship of sperm motility with serum 25‐hydroxyvitamin D3 (25‐OH VD) levels and with ischaemia‐modified albumin (IMA) levels in infertile Turkish men. A total of 30 men with nonobstructive azoospermia (no spermatozoa in ejaculate), 30 men with oligospermia (total progressive motile sperm count (TPMSC) <15 × 106/ml) and 33 fertile men with normospermia (with at least one child, as the control group) were enrolled in the study. The mean 25‐OH VD levels for groups 1, 2 and 3 were 9.31 ± 6.46, 19.71 ± 12.80 and 30.52 ± 12.49 respectively (p < .05). There was a statistically significant difference in serum IMA levels among the groups (479.32 ± 307.56 vs. 296.37 ± 127.27 vs. 150.04 ± 81.05, respectively; p < .05). A positive correlation between serum 25‐OH VD levels and TPMSC, and a negative correlation between TPMSC and serum IMA levels were determined. Infertile men had lower serum 25‐OH VD and higher IMA levels than fertile men, with a positive correlation between serum 25‐OH VD levels and TPMSC, and a negative correlation between TPMSC and serum IMA levels. Vitamin D supplementation may increase the sperm motility.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Investigation of serum vitamin D and ischaemia‐modified albumin levels in infertile Turkish men

İnal¹,

İnal²,

Mermer³

et al. 2020

Andrologia

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“…3,4 This interaction between vitamin D and reproduction is attributed to the presence of both Summary Context: The effects of Vitamin D on reproductive function in adults have gained interest. In addition to its classic effects on bone homoeostasis, many studies have supported that vitamin D receptors (VDRs) are present on various non-musculoskeletal organs and tissues.…”

mentioning

confidence: 99%

“…2 Most recent evidence from human and animal studies also suggests that vitamin D has a potential role in the physiology of reproductive function in both genders. 3,4 This interaction between vitamin D and reproduction is attributed to the presence of both Summary Context: The effects of Vitamin D on reproductive function in adults have gained interest. Studies have demonstrated some associations.…”

mentioning

confidence: 99%

Evaluation of vitamin D status and its correlation with gonadal function in children at mini‐puberty

Kılınç

Atay

Ceran

et al. 2018

Clinical Endocrinology

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Association between vitamin D status, physical performance, sex, and lifestyle factors: a cross-sectional study of community-dwelling Kosovar adults aged 40 years and older

Krasniqi,

Boshnjaku,

Ukëhaxhaj

et al. 2024

Eur J Nutr

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Purpose Vitamin D status and its association with age-related decline in physical performance and strength have already been highlighted in various ways, but data on the situation in developing countries are scarce. This study aimed to investigate vitamin D status, its association with muscle mass and function, and other potential determinants such as age, sex, lifestyle factors (physical activity, dietary behavior), self-perceived health status, medication intake, education and financial situation in adults from Kosovo. Methods This cross-sectional study included 297 participants (54.5% women), aged ≥ 40 years. Serum 25-hydroxyvitamin D (25(OH)D) concentration, hand grip strength and physical performance tests, body composition, vitamin D dietary intake and knowledge were assessed. The interaction between serum 25(OH)D status, lifestyle factors and muscle traits was investigated. Results Vitamin D deficiency (< 50 nmol/L) was observed in 47.5% of the total population, of whom 14.7% of them were severely deficient (< 30 nmol/L). No associations were found between 25(OH)D concentration and age. Daily dietary intake of vitamin D was low (1.89 ± 0.67 µg) and 87.6% of individuals did not take vitamin D supplements. However, vitamin D supplementation was the only variable that added statistical significance (p < 0.05) to the prediction of vitamin D status (3.8%). On the other hand, age, medication intake and vitamin D level contributed significantly to the overall regression model, explaining 24.9% of the 30-s chair stand performance as an indicator of lower-body strength endurance. Conclusion Vitamin D deficiency is highly prevalent among community-dwelling adults in Kosovo and low serum 25(OH)D has been associated with low muscle strength. This implies an urgent need for the development of comprehensive prevention strategies, focusing on pharmacological (supplementation) but also on non-pharmacological strategies such as education, food fortification or lifestyle advices.

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Possible influence of vitamin D on male reproduction

Cited by 71 publications

References 76 publications

Investigation of serum vitamin D and ischaemia‐modified albumin levels in infertile Turkish men

Investigation of serum vitamin D and ischaemia‐modified albumin levels in infertile Turkish men

Evaluation of vitamin D status and its correlation with gonadal function in children at mini‐puberty

Association between vitamin D status, physical performance, sex, and lifestyle factors: a cross-sectional study of community-dwelling Kosovar adults aged 40 years and older

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