Possible Plasticity of Cytotoxic Resident Memory T Cells in Fixed Drug Eruption

Matsumura, Yutaka; Watanabe, Rei; Koguchi‐Yoshioka, Hanako; Kume, Miki; Nakai, Shuichi; Furuta, Junichi; Azukizawa, Hiroaki; Ishitsuka, Yosuke; Tanemura, Atsushi; Taminato, Mifue; Tashima, Hiroki; Otani, Naoya; Tomita, Koichi; Kubo, Tateki; Fujimoto, Manabu

doi:10.1016/j.jid.2022.11.022

Cited by 2 publications

(3 citation statements)

References 16 publications

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“…Interestingly, TCR sequence overlap suggests that this population is not recruited from circulatory T CM but rather trans-differentiates from local cytotoxic T RM . 160 Skin T RM are also implicated in the pathogenesis of other drug-induced or contact allergic dermatoses. Stevens-Johnson syndrome and toxic epidermal necrolysis (TEN) are severe delayed-type drug hypersensitivity reactions resulting in blister formation and high mortality.…”

Section: Drug Reactions and Contact Allergic Diseasementioning

confidence: 99%

“…In addition to high numbers of T RM in healed FDE, active FDE lesions also contain high percentages of T cells with a central memory phenotype (T CM ). Interestingly, TCR sequence overlap suggests that this population is not recruited from circulatory T CM but rather trans‐differentiates from local cytotoxic T RM 160 …”

Section: Trm In Disease Pathogenesismentioning

confidence: 99%

“…Interestingly, TCR sequence overlap suggests that this population is not recruited from circulatory T CM but rather trans‐differentiates from local cytotoxic T RM . 160 …”

Section: T Rm In Disease Pathogenesismentioning

confidence: 99%

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Functional heterogeneity of human skin‐resident memory T cells in health and disease

Strobl

Haniffa

2023

Immunological Reviews

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Summary The human skin is populated by a diverse pool of memory T cells, which can act rapidly in response to pathogens and cancer antigens. Tissue‐resident memory T cells (TRM) have been implicated in range of allergic, autoimmune and inflammatory skin diseases. Clonal expansion of cells with TRM properties is also known to contribute to cutaneous T‐cell lymphoma. Here, we review the heterogeneous phenotypes, transcriptional programs, and effector functions of skin TRM. We summarize recent studies on TRM formation, longevity, plasticity, and retrograde migration and contextualize the findings to skin TRM and their role in maintaining skin homeostasis and altered functions in skin disease.

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Section: Drug Reactions and Contact Allergic Diseasementioning

confidence: 99%

Section: Trm In Disease Pathogenesismentioning

confidence: 99%

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Functional heterogeneity of human skin‐resident memory T cells in health and disease

Strobl

Haniffa

2023

Immunological Reviews

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Resident cutaneous memory T cells: a clinical review of their role in chronic inflammatory dermatoses and potential as therapeutic targets

Pham,

Wark,

Woods

et al. 2023

British Journal of Dermatology

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Resident memory T-cells (T-RMs) remain in epithelial barrier tissues after antigen exposure and the initial effector phase. These T-RMs provide effective antimicrobial and anticancer immunity, however pathogenic T-RMs have been shown to mediate various chronic inflammatory disorders in a variety of tissue types. In the skin, T-RMs are referred to as resident cutaneous memory T-cells (cT-RMs). Understanding the mechanisms leading to the development and establishment of these cT-RMs populations may allow for targeted treatments providing durable responses in chronic immune-mediated skin diseases, even after cessation. In this Review, we summarise the evidence on cT-RMs as drivers of chronic inflammatory dermatoses including psoriasis, vitiligo, atopic dermatitis, cutaneous lupus erythematosus and alopecia areata, among others. Data from in-vitro, animal model, and ex-vivo human studies are presented – with a focus on the potential for cT-RMs to trigger acute disease flares as well as recurrent disease by establishing an immune ‘memory’ in the skin. Furthermore, available data on the potential for existing and novel treatments to affect the development or survival of cT-RMs in the skin are synthesised. These suggest a dynamic and rapidly growing area in the field of dermatology; however we also discuss areas in need of greater research to allow for optimal treatment selection for long-term disease control.

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Possible Plasticity of Cytotoxic Resident Memory T Cells in Fixed Drug Eruption

Cited by 2 publications

References 16 publications

Functional heterogeneity of human skin‐resident memory T cells in health and disease

Functional heterogeneity of human skin‐resident memory T cells in health and disease

Resident cutaneous memory T cells: a clinical review of their role in chronic inflammatory dermatoses and potential as therapeutic targets

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