Possible role of d-serine in the pathophysiology of Alzheimer's disease

Hashimoto, Kenji; Fukushima, Takeshi; Shimizu, Eiji; Okada, Shinichi; Komatsu, Naoya; Okamura, Naoe; Koike, Kaori; Koizumi, Hiroki; Kumakiri, Chikara; Imai, Kazuhiro; Iyo, Masaomi

doi:10.1016/j.pnpbp.2003.11.009

Cited by 99 publications

(61 citation statements)

References 21 publications

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“…Under the Sumichiral separation conditions described in this report, however, the dabsyl citrulline emerged after the glutamine peak and hence did not interfere with the quantitative analysis of d-and l-serine. There have been reports on CSF d-serine analysis in pathophysiology of diseases such as Alzheimer disease and schizophrenia (7,8,21,22 ). We chose to evaluate the possible roles of d-serine in pain, a multidimensional sensory experience.…”

Section: Discussionmentioning

confidence: 99%

Simultaneous Analysis of d- and l-Serine in Cerebrospinal Fluid by Use of HPLC

et al. 2007

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Section: Discussionmentioning

confidence: 99%

Simultaneous Analysis of d- and l-Serine in Cerebrospinal Fluid by Use of HPLC

et al. 2007

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“…[122][123][124] Insufficient use of oral administrated drugs for AD, such as tacrine, memantine, rivastigmine etc, pulls the door open for nanomedicine in neurodegenerative disorders. 125,126 Cerium oxide nanoparticles, 127 SLN of ferulic acid, 128 tempol loaded PLGA nanoparticles, 129 and epigallocatechin-3-gallate (EGCG) phenol coated nanolipids 130 reported to show antioxidant property and degrade amyloid-β.…”

Section: Alzheimer's Diseasementioning

confidence: 99%

Nanomedicine in Central Nervous System (CNS) Disorders: A Present and Future Prospective

Soni¹,

Ruhela²,

Medhi³

2016

Adv Pharm Bull

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“…Thus, more rigorous peptide purification protocols must be designed. The role of D-Ser in the pathophysiology of AD was also studied [81]. The reason of the study was that D-Ser may function as an endogenous agonist of the Gly site on the NMDA receptor that was implicated in the pathophysiology of AD.…”

Section: Chromatographic Determination Of Aas As Possible Biomarkers mentioning

confidence: 99%

Enantiomeric Ratio of Amino Acids as a Tool for Determination of Aging and Disease Diagnostics by Chromatographic Measurement

2016

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Abstract:Occurrence of D-amino acids in living organisms is a useful indicator of various changes, diseases, or disorders. Determination of amino acid enantiomers, namely the enantiomeric ratio of amino acids or excess of certain D-amino acids, represents a useful tool in the studies of aging processes or biomarkers in disease/disorder diagnosis in humans. The amount of D-amino acids is usually very low. Therefore, suitable sample pretreatment, often derivatization, and highly selective and sensitive separation methods are essential for D-amino acid analysis in this field. Chromatographic techniques offer appropriate choices for solving these tasks. This review covers the advances in methodology and development of improved instrumental chromatographic methods focused on D,L-amino acid separation and determination. New findings in the area of possible D-amino acid biomarkers are also included.

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Possible role of d-serine in the pathophysiology of Alzheimer's disease

Cited by 99 publications

References 21 publications

Simultaneous Analysis of d- and l-Serine in Cerebrospinal Fluid by Use of HPLC

Simultaneous Analysis of d- and l-Serine in Cerebrospinal Fluid by Use of HPLC

Nanomedicine in Central Nervous System (CNS) Disorders: A Present and Future Prospective

Enantiomeric Ratio of Amino Acids as a Tool for Determination of Aging and Disease Diagnostics by Chromatographic Measurement

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