Possible therapeutic effects of
            <i>Nigella sativa</i>
            and its thymoquinone on COVID-19

Khazdair, Mohammad Reza; Ghafari, Shokouh; Sadeghi, Mahmood

doi:10.1080/13880209.2021.1931353

Cited by 61 publications

(46 citation statements)

References 79 publications

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“… 47 N. sativa L. has immunoregulatory and anti-inflammatory effects via decreasing many pro-inflammatory cytokine responses. 11 , 29 , 48 In addition, N. sativa L. may have therapeutic effects against immune disturbance, autophagy dysfunction, oxidative stress, ischemia, and inflammation in the COVID-19 associated comorbidities such as diabetes, cardiovascular disorders, and co-infections with bacterial and viral pathogens. 47 The most common comorbidities found in this study were obesity, allergic disorders, smoking, hypertension, diabetes, and asthma.…”

Section: Discussionmentioning

confidence: 99%

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Nigella sativa for the treatment of COVID-19: An open-label randomized controlled clinical trial

Koshak

Mobeireek

et al. 2021

Complementary Therapies in Medicine

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Background Effective treatment for Coronavirus Disease-2019 (COVID-19) is under intensive research. Nigella sativa oil (NSO) is a herbal medicine with antiviral and immunomodulatory activities, and has been recommended for the treatment of COVID-19. This study aimed to evaluate the efficacy of NSO treatment in patients with COVID-19. Methods All adult patients with mild COVID-19 symptoms presented to King Abdulaziz University Hospital, Jeddah, Saudi Arabia, were recruited for an open label randomized clinical trial (RCT). They were randomly divided into control or treatment groups, with the latter receiving 500 mg NSO (MARNYS® Cuminmar) twice daily for 10 days. Symptoms were daily monitored via telecommunication. The primary outcome focused on the percentage of patients who recovered (symptom-free for 3 days) within 14-days. The trial was registered at clinicaltrials.gov (NCT04401202). Results A total of 173 patients were enrolled for RCT. The average age was 36(±11) years, and 53% of patients were males. The control and NSO groups included 87 and 86 patients respectively. The percentage of recovered patients in NSO group (54[62%]) was significantly higher than that in the control group (31[36%]; p = 0.001). The mean duration to recovery was also shorter for patients receiving NSO (10.7 ± 3.2 days) compared with the control group (12.3 ± 2.8 days); p = 0.001. Conclusions NSO supplementation was associated with faster recovery of symptoms than usual care alone for patients with mild COVID-19 infection. These potential therapeutic benefits require further exploration with placebo-controlled, double-blinded studies.

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Section: Discussionmentioning

confidence: 99%

“… 9 Particularly, Nigella sativa L is suggested as a potential phytomedicine owing to its several pharmacological activities such as anti-inflammatory, anti-viral, and immunomodulatory effects. 10 , 11 …”

Section: Introductionmentioning

confidence: 99%

Nigella sativa for the treatment of COVID-19: An open-label randomized controlled clinical trial

Koshak

Mobeireek

et al. 2021

Complementary Therapies in Medicine

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“…Thymoquinone is the main active component of Nigella sativa and has demonstrated several pharmacological effects, such as immunomodulation, anticancer, anti-inflammatory, antiasthmatic, and antioxidant effects [ 9 , 10 , 11 , 12 , 13 ]. Recently, research has been focused on its benefits for the prevention and cure of COVID-19 [ 4 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Novel Thymoquinone Nanoparticles Using Poly(ester amide) Based on L-Arginine-Targeting Pulmonary Drug Delivery

et al. 2022

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Thymoquinone (TQ), the main active constituent of Nigella sativa, has demonstrated broad-spectrum antimicrobial, antioxidant, and anti-inflammatory effects, which suggest its potential use in secondary infections caused by COVID-19. However, clinical deployment has been hindered due to its limited aqueous solubility and poor bioavailability. Therefore, a targeted delivery system to the lungs using nanotechnology is needed to overcome limitations encountered with TQ. In this project, a novel TQ-loaded poly(ester amide) based on L-arginine nanoparticles was prepared using the interfacial polycondensation method for a dry powder inhaler targeting delivery of TQ to the lungs. The nanoparticles were characterized by FTIR and NMR to confirm the structure. Transmission electron microscopy and Zetasizer results confirmed the particle diameter of 52 nm. The high-dose formulation showed the entrapment efficiency and loading capacity values of TQ to be 99.77% and 35.56%, respectively. An XRD study proved that TQ did not change its crystallinity, which was further confirmed by the DSC study. Optimized nanoparticles were evaluated for their in vitro aerodynamic performance, which demonstrated an effective delivery of 22.7–23.7% of the nominal dose into the lower parts of the lungs. The high drug-targeting potential and efficiency demonstrates the significant role of the TQ nanoparticles for potential application in COVID-19 and other respiratory conditions.

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“…Экстракты из растений нигеллы посевной могут быть использованы в качестве антималярийного средства [62]. Особый интерес вызывают последние исследования ряда ученых [63][64], показывающих большую перспективность нигеллы посевной в профилактике и лечении COVID-19, что еще раз подтверждает уникальность этого растения.…”

Section: рис2 структурные формулы изохинолиновых и пиразоловых алкалоидов Fig 2 Structural Formulas Of Isoquinoline and Pyrazole Alkaloidunclassified

Nigella is a valuable economically useful crop (literature review)

Прохоров

2021

Ovoŝi Rossii

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The most important task for the sustainable development of modern agriculture is to increase the biological diversity of cultivated crops. In recent years, due to global climate change, the possibilities of using more thermophilic crops in new agro-ecological zones have expanded. The problem of increasing the biological diversity of vegetable products largely depends on the introduction of non-traditional plant species, with a simultaneous assessment of the initial material for its use in economically useful purposes and the creation of varieties and hybrids adapted to local conditions. In this regard, Nigella L. is of great interest among rare plant species. It is one of the most famous spicy-aromatic crops in the Mediterranean and Central Asia, possessing a wide range of biologically active compounds and unique medicinal properties. The review article provides information on the origin, biological characteristics and breeding of the culture. A brief review of food, medicinal and other economically useful properties is given, as well as the main elements of the technology for growing nigella are considered. It is shown that the cultivation of this culture will provide an opportunity to expand the range of non-traditional plants and be a promising renewable source of valuable plant raw materials, which will find application in various fields: in agriculture, in the food, pharmaceutical, perfumery and cosmetic industries, as well as in ornamental gardening.

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Possible therapeutic effects of Nigella sativa and its thymoquinone on COVID-19

Cited by 61 publications

References 79 publications

Nigella sativa for the treatment of COVID-19: An open-label randomized controlled clinical trial

Nigella sativa for the treatment of COVID-19: An open-label randomized controlled clinical trial

Novel Thymoquinone Nanoparticles Using Poly(ester amide) Based on L-Arginine-Targeting Pulmonary Drug Delivery

Nigella is a valuable economically useful crop (literature review)

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