Post-Mortem Compared with Clinical Diagnosis of Genito-Urinary Tuberculosis in Adult Males

Medlar, E. M.; Spain, David M.; Holliday, R.W.

doi:10.1016/s0022-5347(17)69186-9

Cited by 94 publications

(30 citation statements)

References 2 publications

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“…In our study, both renal transplant patients, as already reported [7,8], and AIDS patients had features of urogenital tuberculosis that differed In urogenital tuberculosis, renal lesions are initially bilateral, cortical, glomerular, and pericapillary, characterizing a hematogenic origin, a fact reinforced by the simultaneous occurrence of other hematogenic foci in the prostate and other organs beyond the urogenital system [10,11]. This phase is usually subclinical, the patient entering a latent period.…”

Section: Discussionsupporting

confidence: 67%

“…This accounts for the greater frequency of unilateral renal involvement [12,13]. Contiguous spread to the collecting system leads to bacilluria and downward spread to the ureter, bladder, and genital organs [10]. Bladder contraction and the associated reflux injure the contralateral kidney [14].…”

Section: Discussionmentioning

confidence: 99%

“…Although the initial bacillemia with metastatic spread to parenchymatous organs secondary to pulmonary tuberculosis infection is usually subclinical, in the context of immunosuppression, miliary tuberculosis may develop, with consequent systemic symptoms and visceral abscess formation [1]. In 25-62% of the patients with miliary tuberculosis, there is renal lesion with multiple bilateral foci [10,19]. A higher incidence of tuberculosis prostate and renal abscesses has been reported in AIDS patients, highlighting this clinical manifestation with parenchymatous involvement following hematogenic spread [20].…”

Section: Discussionmentioning

confidence: 99%

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Urogenital tuberculosis in immunocompromised patients

et al. 2008

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Section: Discussionsupporting

confidence: 67%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Urogenital tuberculosis in immunocompromised patients

et al. 2008

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“…The clinical symptoms of GUTB vary according to interactions between the host and M. tuberculosis . Dysuria, hesitancy, and frequency commonly occur in renal and prostatic tuberculosis, and some cases of renal tuberculosis present with dysuria and flank pain [12]. …”

Section: Discussionmentioning

confidence: 99%

Clinical Characteristics of Genitourinary Tuberculosis during a Recent 10-Year Period in One Center

Lee

Park

et al. 2011

Korean J Urol

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PurposeThis study was conducted to analyze the clinical characteristics and treatments of patients with genitourinary tuberculosis (GUTB) over the past 10 years.Materials and MethodsThe study population comprised 101 patients who were diagnosed with GUTB and hospitalized from January 2000 to December 2009. Acid-fast bacilli (AFB) smear, urine tuberculosis culture, urine tuberculosis polymerase chain reaction (PCR), intravenous urography, cystoscopy, and histopathologic findings were used for patient selection. Yearly proportion, gender, patient distribution according to age, history of tuberculosis, and presence of other organ tuberculosis were analyzed.ResultsThe patients hospitalized with GUTB counted for 0.9% of all patients admitted to the department of urology. The sex ratio was 1:1.53 (male:female), and the patients' mean age was 45.57±12.55 years (range, 19-81 years). Among the patients, there was one immunocompromised patient. A total of 22 patients (21.8%) had a medical history of tuberculosis, mostly pulmonary tuberculosis (90.9%). The sensitivity of AFB stain, tuberculosis culture, and PCR was 41.6%, 55.4%, 33.7%, respectively. A total of 54 patients required additional surgical treatment: 30 cases of nephrectomy, 8 cases of epididymectomy, 8 cases of ureteral stent, 5 cases of nephrostomy, 1 case of ureterectomy, 1 case of augmentation cystoplasty, and 1 case of transurethral resection of prostate.ConclusionsThe frequency of GUTB tended to decrease progressively. However, GUTB is still a threat to public health. There was no previous history of tuberculosis in two-thirds of the cases of GUTB and more than half of them required further surgical treatment.

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“…Stelle der extrapulmonalen Manifestationen [7,8,9,17,19]. Die durch Nierentuberkulose bedingten Organveränderungen präsentieren sich meist einseitig; Postmortem-Studien zeigten jedoch häufig einen beidseitigen tuberkulösen Organbefall [20].…”

Section: Epidemiologieunclassified

Urogenitaltuberkulose in Deutschland

Lenk¹

2011

Urologe

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Genitourinary tuberculosis (GUTB) usually results from the reactivation of old, dormant tuberculous diseases by pathogens of the Mycobacterium tuberculosis complex. The diagnosis of tuberculosis of the urinary tract is based on the case history, the finding of pyuria in the absence of infection as judged by culture on routine media and by radiological imaging. A positive yellow egg culture and/or histological analysis of biopsy specimens possibly combined with the polymerase chain reaction (PCR) is still required in most patients to establish a definitive diagnosis of GUTB. Antituberculous drug treatment is based on an initial 2 month intensive phase with three or four drugs daily followed by a 4 month continuation phase with only two drugs. Surgery as a treatment option in GUTB might be indicated in complicated urinary tuberculosis. After antituberculous treatment of GUTB a follow-up surveillance over 5 years is recommended. Although the incidence of GUTB in Germany is relatively low, it is still necessary to impart and deepen scientific knowledge of the diagnosis and therapy of GUTB.

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Post-Mortem Compared with Clinical Diagnosis of Genito-Urinary Tuberculosis in Adult Males

Cited by 94 publications

References 2 publications

Urogenital tuberculosis in immunocompromised patients

Urogenital tuberculosis in immunocompromised patients

Clinical Characteristics of Genitourinary Tuberculosis during a Recent 10-Year Period in One Center

Urogenitaltuberkulose in Deutschland

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