Post-thrombotic syndrome and venous disease-specific quality of life in patients with vascular Behçet's disease

Alıbaz-Öner, Fatma; Aldağ, Belgin; Aldağ, Mustafa; Ünal, AU; Mutis, Aydan; Toptaş, Tayfur; Ergun, Tülin; Direşkeneli, Haner

doi:10.1016/j.jvsv.2016.01.003

Cited by 22 publications

(17 citation statements)

References 32 publications

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“…The work‐day loss among those with vascular complaints reaches to almost 2 months during the preceding year. Vasculitis as a primary pathologic feature affects both arterial and venous systems with all sized vessels in BS and venous involvement is reported to be more common in young male patients . Since vascular involvement is a severe health problem leading to mortality and morbidity, the primary goal of treatment protocols for vascular disease is to control disease‐related symptoms, increase survival and to prevent relapses in BS.…”

Section: Discussionmentioning

confidence: 99%

“…Systemic IS medications are used to reduce inflammation and endothelial damage leading to the formation of thrombus. Since venous stasis, leg pain, ulcers on the leg, limitation in walking capacity and mobility are critical problems affecting daily life of patients with vascular involvement, increase in work‐day loss could be predicted.…”

Section: Discussionmentioning

confidence: 99%

“…Vasculitis as a primary pathologic feature affects both arterial and venous systems with all sized vessels in BS and venous involvement is reported to be more common in young male patients. 29 Since vascular involvement is a severe health problem leading to mortality and morbidity, 17,19 the pri-…”

Section: Patients Without Work-day Lossmentioning

confidence: 99%

“…A severe disease course is commonly seen in males and treated with immunosuppressive medications (IS) . Occurrence of unpredictable relapses and life‐threatening conditions are crucial components of the disease pattern; workplace problems could be seen in patients with severe organ involvement, especially young males . Since workplace problems are thought to be an indicator to modify treatment protocols of employed patients for physicians, the evaluation of employment life of BS patients is critical in disease management .…”

Section: Introductionmentioning

confidence: 99%

“…17,18 Occurrence of unpredictable relapses and life-threatening conditions are crucial components of the disease pattern; workplace problems could be seen in patients with severe organ involvement, especially young males. 9,[19][20][21][22][23][24][25][26][27][28][29][30][31][32] Since workplace problems are thought to be an indicator to modify treatment protocols of employed patients for physicians, the evaluation of employment life of BS patients is critical in disease management. 2,24,25 In this perspective, the mean sick leave days or disabled days as workdays lost for the last year were reported as 173 ± 79 for neurological involvement, 134 ± 87 for ocular involvement and 75 ± 100 for vascular involvement in BS in a previous study.…”

Section: Introductionmentioning

confidence: 99%

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Predictive factors for work‐day loss in Behçet's syndrome: A multi‐center study

et al. 2019

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Objective The aim of this multi‐center study was to assess predictive factors for work‐day loss as an indirect cost element in Behçet's syndrome (BS). Methods In this cross‐sectional, multi‐center study, 834 BS patients (F/M: 441/393, age mean: 38.4 ± 10.9 years) were included. Data were collected by a questionnaire regarding treatment protocols, disease duration, smoking pattern, frequency of medical visits during the previous year and self‐reported work‐day loss during the previous year. Results Work‐day loss was observed in 16.2% of patients (M/F: 103/32). The percentages of being a smoker (81.8%), using immunosuppressive (IS) medications (82%), and having disease duration <5 years (74%) were higher in male patients with work‐day loss (P < .05). The majority of males (90.9%) had more than four clinic visits during the previous year. Moreover, the mean work‐day loss (30.8 ± 57.7 days) was higher in patients with vascular involvement (56.1 ± 85.9) than those without (26.4 ± 50.6 days) (P = .046). In addition, increased frequency of ocular involvement (25.9%) was also observed in patients with work‐day loss compared to others (8.6%) (P = .059). Conclusion Work‐day loss was associated with both vascular and ocular involvement. Close associations were observed among male gender, early period of the disease, frequent medical visits, being a smoker and treatment with IS medications in patients with work‐day loss.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Patients Without Work-day Lossmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Predictive factors for work‐day loss in Behçet's syndrome: A multi‐center study

et al. 2019

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A systematic review and meta‐analysis of the association between the D‐dimer and rheumatic diseases

Zinellu,

Mangoni

2024

Immunity Inflam & Disease

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IntroductionThere is good evidence that specific autoimmune rheumatic diseases (RDs), for example, rheumatoid arthritis and systemic lupus erythematosus (SLE), are associated with a state of hypercoagulability and an increased risk of venous thromboembolism (VTE). However, limited information regarding this association is available for other autoimmune or autoinflammatory RDs. We sought to address this issue by conducting a systematic review and meta‐analysis of the association between the d‐dimer, an established marker of hypercoagulability and VTE, and RDs and the possible clinical and demographic factors mediating this association.MethodsWe searched the electronic databases PubMed, Web of Science, and Scopus from inception to January 31, 2024. The risk of bias and the certainty of evidence were assessed using the Joanna Briggs Institute Critical Appraisal Checklist and GRADE, respectively.ResultsIn 31 studies selected for analysis (2724 RD patients and 3437 healthy controls), RD patients had overall significantly higher d‐dimer concentrations when compared to controls (standard mean difference = 0.93, 95% CI 0.76−1.10, p < .001; I2 = 86.1%, p < .001; moderate certainty of evidence). The results were stable in a sensitivity analysis. Significant associations were observed between the effect size of the between‐group differences in d‐dimer concentration and age, specific RD and RD category, RD duration, fibrinogen, plasminogen activator inhibitor, C‐reactive protein, and erythrocyte sedimentation rate.ConclusionsOverall, patients with RDs have significantly higher d‐dimer concentrations when compared with healthy controls, indicating a state of hypercoagulability. The alterations in d‐dimer concentrations are mediated by age, specific RD and RD category, RD duration, and markers of anticoagulation and inflammation. Further research is warranted to investigate d‐dimer concentrations across the spectrum of RDs and their utility in predicting and managing VTE in these patients (PROSPERO registration number: CRD42024517712).

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The psychological impact of Behçet's disease

Hasbani

Uthman

Jawad³

et al. 2022

Musculoskeletal Care

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Background Bechet's disease (BD), a chronic multiorgan involving disease, has a significant impact on quality of life in spite of effective treatment modalities. Disease manifestations such as arthritis, orogenital ulcerations, rashes, angiitis, and neurological involvement affect health‐related quality of life (HRQoL) through its impact on depression, anxiety, and fatigue. Objectives We aimed explore the psychological impact of BD, taking into consideration the effect on the HRQoL, as well as the association with depression, anxiety, wellbeing, and fatigue. Methods This is a narrative review of the literature that looks into the association of BD on the HRQoL including all studies that have assessed such as association. Results/Findings Depression and anxiety are prevalent among patients with BD, and contribute significantly to fatigue, a common symptom among BD patients. In addition, the psychological wellbeing is affected by the disease, however, more studies are needed to assess this relationship. Conclusion Depression and anxiety are strongly associated with BD, and contribute significantly to fatigue, a common symptom among BD patients. In addition, the psychological wellbeing is affected by the disease, however, more studies are needed to assess this relationship. Besides, the controlling factors of the psychological impact are still to be deciphered.

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Post-thrombotic syndrome and venous disease-specific quality of life in patients with vascular Behçet's disease

Cited by 22 publications

References 32 publications

Predictive factors for work‐day loss in Behçet's syndrome: A multi‐center study

Predictive factors for work‐day loss in Behçet's syndrome: A multi‐center study

A systematic review and meta‐analysis of the association between the D‐dimer and rheumatic diseases

The psychological impact of Behçet's disease

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