Postmenopausal Symptoms in Female Veterans with Type 2 Diabetes: Glucose Control and Symptom Severity

Rouen, Patricia A.; Krein, Sarah L.; Reame, Nancy E.

doi:10.1089/jwh.2014.4863

Cited by 13 publications

(12 citation statements)

References 83 publications

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“…26 Rouen et al reported that in postmenopausal women having type 2 diabetes glucose control is associated with the severity of those symptoms commonly attributed to menopause such as joint pain. 27 Hart et al also reported that in women of age 45-64 years blood glucose was associated with unilateral and bilateral knee osteoarthritis. 28 The possible explanation of link between hyperglycemia and osteoarthritis that hyperglycemia can induce an inflammatory state, and that an inflammatory state might predispose cartilage to damage that leads to osteoarthritis.…”

Section: Discussionmentioning

confidence: 95%

Status of soluble vascular cell adhesion molecule-1 in knee osteoarthritis among type 2-diabetic postmenopausal women

Shrivastava

Singh

Chandel³

et al. 2017

Int J Res Med Sci

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INTRODUCTIONKnee pain is one of the most common musculoskeletal complaints that bring people to their physician and the most common cause of knee pain is osteoarthritis. 1 Especially in females, knee osteoarthritis is the major cause of mobility impairment.2,3 Nearly, 45% of women over the age of 65 years have symptomatic findings of knee osteoarthritis while radiological evidence is found in 70% of those over 65 years.2-4 In India, average menopausal age in women is 46.3 years as compared to 54 years in western countries. 5,6 This predisposes Indian women at higher risk of developing osteoarthritis in earlier age as compared to their western counterparts. It could be due to loss of estrogen especially close to menopausal years at this time. 7,8ABSTRACT Background: Knee osteoarthritis is the most common form of joint disorder and a leading cause of pain and functional disability among elderly female population. Type 2-diabetes is frequently reported comorbidity in elderly female patients with knee osteoarthritis. VCAM-1 is emerging as a strong and independent predictor for severe osteoarthritis. VCAM-1 is an inducible cell surface sialo glycoprotein and mediates heterotypic cellular aggregation. Therefore, the aim of this study is to assess the role of soluble vascular cell adhesion molecule-1 at the onset of knee osteoarthritis among type 2 diabetic postmenopausal women. Methods: The present study includes 100 type 2-diabetic female subjects of age above 50 years as cases and 100 normal healthy female age matched individuals as controls. Osteoarthritis of knee was ascertained using the American college of rheumatology classification criteria. Serum soluble VCAM-1 concentration was measured by ELISA method in all 200 subjects. Biochemical parameters-Fasting blood sugar and lipid profile were measured using Mind ray BS-400 and HbA1c was measured by turbidimetric immunoassay method. Statistical analysis was made by student independent sample t-test. Correlation was determined by using spearman's rank correlation coefficient. Results: Serum level of soluble VCAM-1 was found statistically highly significant (p<0.001) in type 2 diabetic postmenopausal women having early stage of knee osteoarthritis as compared to control healthy subjects. The mean levels of fasting blood sugar, HbA1c, total cholesterol, TG, LDL-C and VLDL-C were also found significantly increased while HDL-C was found significantly decreased in cases as compared to controls. Conclusions: The increased level of soluble VCAM-1 in type 2 diabetic subjects shows active inflammation or cartilage damage. Therefore, it can be used as an early biomarker for osteoarthritis among type 2 diabetic postmenopausal women.

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Section: Discussionmentioning

confidence: 95%

Status of soluble vascular cell adhesion molecule-1 in knee osteoarthritis among type 2-diabetic postmenopausal women

Shrivastava

Singh

Chandel³

et al. 2017

Int J Res Med Sci

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“…Interestingly, a recent study showed that T. foenum‐graecum seed extract significantly decreased serum pro‐inflammatory cytokines (IL‐1, IL‐6 and TNF‐α) and improved metabolic symptoms (including significantly blunting elevated blood glucose levels) in a similar manner to estrogen administration, in ovariectomized rats, a standard experimental model of menopause in rodents (Abedinzade et al , ). Previous studies have reported that compromised glycemic control is also a mediator of hot flush severity during menopause and that diabetic women with elevated HbA1c demonstrated higher menopausal symptom severity scores (Rouen et al , ). Recent studies have shown that T. foenum‐graecum seed is effective in reducing the symptoms of diabetes mellitus (Verma et al , ).…”

Section: Discussionmentioning

confidence: 99%

Efficacy of a Proprietary Trigonella foenum‐graecum L. De‐Husked Seed Extract in Reducing Menopausal Symptoms in Otherwise Healthy Women: A Double‐Blind, Randomized, Placebo‐Controlled Study

Steels

Steele

Harold³

et al. 2017

Phytotherapy Research

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Trigonella foenum-graecum seed extract has demonstrated hormone modulatory activity, providing biological plausibility for relieving menopausal symptoms. The study aimed to assess efficacy of a standardized T. foenum-graecum de-husked seed extract in reducing menopausal symptoms in healthy aging women. The study was a double-blind, randomized, placebo-controlled trial that recruited 115 women aged 40 to 65 years of which 59 were allocated to active (n = 54 completed) and 56 to placebo (n = 50 completed). Active treatment was T. foenum-graecum de-husked seed extract, 600 mg per day for 12 weeks. Outcome measures included Menopause-Specific Quality of Life (MENQOL) questionnaire, frequency of hot flushes and night sweats and serum estradiol levels. There was a significant reduction in menopausal symptoms in the active group compared with placebo as assessed by total MENQOL score (p < 0.001); reflected by significant improvements in the vasomotor (p < 0.001), psychosocial (p < 0.001), physical (p < 0.001) and sexual symptoms (p < 0.001) domains. Vasomotor outcomes correlated with hot flushes, the active group reporting significantly less daytime hot flushes and night sweats at 12 weeks (p < 0.001). The average estradiol levels were similar in both the active group and placebo group after treatment. This study demonstrated that this proprietary T. foenum-graecum de-husked seed extract may reduce menopausal symptoms in healthy women. Copyright © 2017 John Wiley & Sons, Ltd.

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“…W badaniu przeprowadzonym przez Rouen i wsp. wykazano, że respondentki z podwyższonym poziomem HbA1c miały większe nasilenie objawów menopauzalnych niż pozostałe osoby [15].…”

Section: Dyskusjaunclassified

Analysis of the relationship between the severity of climacteric and depressive symptoms in healthy women and those with type 2 diabetes

Zimny

Kotwas

Schneider-Motyka

et al. 2019

Pomeranian Journal of Life Sciences

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Introduction: Menopause, being a natural period associated with the cessation of ovarian function, is one of physiological stages in a woman's life. Epidemiological studies show that this is when women are at the greatest risk of depressive disorders. Other common conditions observed in menopausal women are various metabolic disorders, including type 2 diabetes. The aim of this study was to determine the relationship between climacteric and depressive symptoms in healthy women and those with type 2 diabetes. Materials and methods: This survey-based study involved 103 women aged 44-65 years, including 33 with type 2 dia betes. Research instruments were: the Kupperman Index for the severity of climacteric symptoms, and the Beck Depression Inventory for the severity of depressive symptoms. Results: The analysis did not reveal any statistically significant relationship between the severity of depressive symptoms and type 2 diabetes. At the same time, it demonstrated that the lack of energy dependent on the severity of depressive symptoms in women with type 2 diabetes. The severity of depressive symptoms in the group of non-diabetic women contributed to the severity of sleep disorders, vertigo, and a lack of energy. Conclusions: Climacteric symptoms significantly affect biopsychosocial status of perimenopausal women, irrespective of whether they have type 2 diabetes.

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Postmenopausal Symptoms in Female Veterans with Type 2 Diabetes: Glucose Control and Symptom Severity

Abstract: In postmenopausal female veterans with diabetes, glucose control is associated with the severity of those symptoms commonly attributed to menopause. Joint pain is an important part of the postmenopausal symptom complex in this population.

Cited by 13 publications

References 83 publications

Status of soluble vascular cell adhesion molecule-1 in knee osteoarthritis among type 2-diabetic postmenopausal women

Status of soluble vascular cell adhesion molecule-1 in knee osteoarthritis among type 2-diabetic postmenopausal women

Efficacy of a Proprietary Trigonella foenum‐graecum L. De‐Husked Seed Extract in Reducing Menopausal Symptoms in Otherwise Healthy Women: A Double‐Blind, Randomized, Placebo‐Controlled Study

Analysis of the relationship between the severity of climacteric and depressive symptoms in healthy women and those with type 2 diabetes

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