Postmenopausal virilization due to ovarian hyperthecosis

Αγοραστός, Θεόδωρος; Argyriadis, N.; Fraggidis, G.; Vakiani, Andromache; Zournatzi, V.; Bontis, J.

doi:10.1007/bf00634494

Cited by 9 publications

(2 citation statements)

References 5 publications

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“…Most of our knowledge on the clinical, endocrinological, and pathological features of hyperthecosis is derived from single case reports5–7 or small series8, 9. Therefore, the prevalence of the disease is unknown.…”

Section: Introductionmentioning

confidence: 99%

Ovarian hyperthecosis on grayscale and color Doppler ultrasound

Rousset

Gompel

Christin-Maître

et al. 2008

Ultrasound in Obstet & Gyne

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Section: Introductionmentioning

confidence: 99%

Ovarian hyperthecosis on grayscale and color Doppler ultrasound

Rousset

Gompel

Christin-Maître

et al. 2008

Ultrasound in Obstet & Gyne

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“…Not all patients with elevated serum testosterone levels suffer from androgenetic alopecia. There has been a case report of a postmenopausal woman who suffered from virilization without androgenetic alopecia as a result of ovarian hyperthecosis 14 . This may be related to individual differences in the sensitivity of hair follicles to dihydrotestosterone.…”

Section: Discussionmentioning

confidence: 99%

Androgenetic alopecia in a postmenopausal woman as a result of ovarian hyperthecosis

Kim

Marjoniemi²,

Diamond

et al. 2003

Aust J Dermatology

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A 65-year-old woman presented with an 8-year history of progressive frontotemporal alopecia and hirsutism. She had elevated serum levels of testosterone, androstenedione and estradiol. Ultrasound and computed tomography imaging suggested a right ovarian mass, while bilateral ovarian venous sampling demonstrated increased testosterone levels originating from both ovarian veins. Histology obtained following bilateral oophorectomy demonstrated bilateral ovarian hyperthecosis. Six months after surgery, the patient remains well with no progression of the alopecia. Ovarian hyperthecosis is a rare cause of androgenetic alopecia in postmenopausal women. The role of hyperthecosis and its relationship to androgenetic alopecia is reviewed.

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Acute goserelin administration inhibits gonadotropin and androgen secretion in post-menopausal women with ovarian hyperandrogenism

Bisceglie

Brocato

Tagliabue

et al. 2003

J Endocrinol Invest

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The aim of this study was to verify the effect of goserelin, a GnRH agonist, in women with post-menopausal virilization. Six patients with post-menopausal virilization and increase in 17-hydroxyprogesterone (17-OHP), total (TT) and free testosterone (FT) levels underwent single subcutaneous administration of goserelin, 3.6 mg. Serum 17-OHP, TT, FT, LH, FSH, E2, delta4 and 3alpha-andro-stanediol glucuronide levels were measured before and 4, 8 and 18 days after goserelin administration. Goserelin administration was followed by progressive inhibition of FSH and LH, which fell to premenopausal levels on day 18, and progressive normalization of androgen parameters. The low E2 levels recorded at baseline were further reduced by goserelin administration. Four patients then underwent ovariectomy while in two patients, rejecting surgical treatment, goserelin treatment was protracted up to 6 and 12 months, respectively, with remission of hyperandrogenism. This study shows that in post-menopausal patients with virilization GnRH agonist allows to confirm the diagnosis of gonadotropin-dependent ovarian hyperandrogenism: its administration induces inhibition of gonadotropin levels, normalization of androgen parameters, and remission of virilization when the treatment is protracted in patients waiting for surgery.

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Postmenopausal virilization due to ovarian hyperthecosis

Cited by 9 publications

References 5 publications

Ovarian hyperthecosis on grayscale and color Doppler ultrasound

Ovarian hyperthecosis on grayscale and color Doppler ultrasound

Androgenetic alopecia in a postmenopausal woman as a result of ovarian hyperthecosis

Acute goserelin administration inhibits gonadotropin and androgen secretion in post-menopausal women with ovarian hyperandrogenism

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