Postnatal development of GABA-immunoreactive terminals in the reticular and ventrobasal nuclei of the rat thalamus: A light and electron microscopic study

Biasi, S. De; Amadeo, Alida; Arcelli, P.; Frassoni, Carolina; Spreafico, Roberto

doi:10.1016/s0306-4522(96)00376-4

Cited by 28 publications

(30 citation statements)

References 46 publications

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“…Although they do not express all the features of mature synaptic boutons, they are quite numerous. This is in contrast to the findings of De Biasi et al [10] in the rat somatosensory thalamus where GABAergic synapses were very scarce at P0. Moreover, the profiles with electron-transparent cytoplasm with a few vesicles and vacuoles identified as GABAergic growth cones by De Biasi et al [10] were not identified at P0 in the nuclei studied here.…”

Section: Discussioncontrasting

confidence: 99%

“…This is in contrast to the findings of De Biasi et al [10] in the rat somatosensory thalamus where GABAergic synapses were very scarce at P0. Moreover, the profiles with electron-transparent cytoplasm with a few vesicles and vacuoles identified as GABAergic growth cones by De Biasi et al [10] were not identified at P0 in the nuclei studied here. Instead, the structures identified as growth cones at P0 in our study were filled with organelles and had rather dense cytoplasm similar to that described by Gotow and Sotelo [16] in the rat inferior olive.…”

Section: Discussioncontrasting

confidence: 99%

“…The degenerating profiles observed in the VM and VA nuclei at P14 displayed the whole spectrum of this sequence. De Biasi et al [10] did not mention degenerating reticular boutons in the VB nucleus between P0 and P21. However, Aggelopoulus et al [23] found degenerating synaptic profiles in the rat lateral geniculate nucleus between P10 and P20, which is roughly the same stage at which degenerating boutons were observed in this study.…”

Section: Discussionmentioning

confidence: 99%

“…This study was undertaken since little, if anything, is known on the synaptogenesis of GABAergic systems in the motor thalamic nuclei in any species. The postnatal development of GABAergic synapses has been analyzed at the electron microscopic level in the rat somatosensory thalamus [ventrobasal (VB) nucleus] where the single source of the GABAergic input is the reticular thalamic nucleus [10]. The questions asked in this study were: (1) when in the postnatal development identifiable basal ganglia afferent terminals can be recognized in the two thalamic regions: VM nucleus and the region anterior to the VL nucleus, which we call VA nucleus; (2) at what stage they acquire adult features, and (3) how their maturation is comparable with that of GABAergic terminals of the reticular nucleus described by De Biasi et al [10] in the postnatal development of the rat somatosensory thalamus.…”

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confidence: 99%

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Postnatal Development of GABAergic Synapses in the Nigral and Entopeduncular Afferent Territory of the Rat Thalamus

Kultas‐Ilinsky

Verney

2003

Neuroembryol Aging

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The time course of the development of GABAergic synapses in the basal ganglion afferent territories of the rat thalamus (the projection zones of the nigro- and entopedunculothalamic afferents) was analyzed at the electron microscopic level. The analysis was carried out in conventionally processed tissue and the tissue was processed for postembedding immunocytochemistry for GABA. It was primarily focused on the development of axosomatic synapses known as the main termination mode of the basal ganglion thalamic afferents. In neonatal rats (P0), small-to-medium-sized axons and large axonal growth cone-like GABA-immunoreactive structures were found engaged in symmetrical synapses with neuronal somata and proximal dendrites. At P7, the size of the axosomatic profiles was considerably increased and synapses appeared more mature. Between P7 and P14, there were numerous degenerating GABA-positive synaptic profiles displaying symmetrical synaptic contacts. Normal-looking GABA-positive terminals were large, extending for several micrometers along the somata and primary dendrites of thalamic neurons. By P21, these boutons acquired the appearance of axosomatic boutons in the adult, i.e., of a large elongated shape, numerous mitochondria, multiple synaptic contacts of pleomorphic vesicles and numerous puncta adherentia. The time course was different from the one described in the somatosensory thalamus by other authors, implying that anatomical and connectional differences between thalamic nuclei are also reflected in the patterns of their synaptogenesis.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Postnatal Development of GABAergic Synapses in the Nigral and Entopeduncular Afferent Territory of the Rat Thalamus

Kultas‐Ilinsky

Verney

2003

Neuroembryol Aging

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“…While the development of TRN-MGB synaptic properties has not been studied to date, GABA immunoreactivity has been reported in all sensory sectors of the TRN from P0 (De Biasi et al 1997). In the VB nucleus of rodents, TRN-VB IPSPs are composed of GABA A and GABA B components, both present from P0 (Evrard and Ropert 2009;).…”

Section: Development Of Ic-mgb Inhibition Versus Other Sources Of Inhmentioning

confidence: 99%

Postnatal development of synaptic properties of the GABAergic projection from the inferior colliculus to the auditory thalamus

Venkataraman

Bartlett

2013

Journal of Neurophysiology

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Immunocytochemical and ultrastructural study of the rat perireticular thalamic nucleus during postnatal development

et al. 1998

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The perireticular thalamic nucleus (PRT) consists of scattered neurons that are located in the internal capsule adjacent to the gamma aminobutyric acid (GABA)-immunoreactive (ir) reticular thalamic nucleus (RT) and whose number decreases during development. The common feature of PRT neurons in different species is the immunoreactivity for the calcium binding protein parvalbumin (PV), which is also expressed by RT cells. In this study, we analyzed, at the light and electron microscopic level, the distribution and morphology of PV-ir neurons and their relationship with GABA in adult and developing rats. We found that the rostrocaudal distribution and the morphology of PV-ir neurons of the PRT were different at each stage of postnatal development examined. The adult configuration of the PV-ir population in the PRT was achieved at postnatal day 21. With electron microscopy, the developing PRT was observed to contain PV-ir neuronal cell bodies and dendrites contacted by several PV-negative synaptic terminals, some of which were GABA-ir, whereas the adult PRT contained also large PV-ir boutons, generally GABA-ir. Very few GABA-ir neurons were found in the PRT region and only during the first postnatal week, thus indicating that the PV-ir neurons of PRT represent a distinct population from those of RT. Our results demonstrate a morphological, neurochemical, and ultrastructural complexity of the PRT not only during development, but also in adulthood. These findings provide new data supporting the suggested roles of the PRT during postnatal development, and may indicate that in adult life it can play other so far unknown functions.

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Postnatal development of GABA-immunoreactive terminals in the reticular and ventrobasal nuclei of the rat thalamus: A light and electron microscopic study

Cited by 28 publications

References 46 publications

Postnatal Development of GABAergic Synapses in the Nigral and Entopeduncular Afferent Territory of the Rat Thalamus

Postnatal Development of GABAergic Synapses in the Nigral and Entopeduncular Afferent Territory of the Rat Thalamus

Postnatal development of synaptic properties of the GABAergic projection from the inferior colliculus to the auditory thalamus

Immunocytochemical and ultrastructural study of the rat perireticular thalamic nucleus during postnatal development

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