2015
DOI: 10.1016/j.peptides.2015.05.003
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Postnatal weight gain induced by overfeeding pups and maternal high-fat diet during the lactation period modulates glucose metabolism and the production of pancreatic and gastrointestinal peptides

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Cited by 31 publications
(36 citation statements)
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“…Our data confirm previous findings showing that maternal HFD feeding during lactation in rodents results in metabolic alterations in the offspring (5, 6, 8, 43). From postnatal d 1 to 21, offspring from HFD‐fed mothers gained 23% more body weight than those from CD‐fed dams (Fig.…”
Section: Resultssupporting
confidence: 92%
See 1 more Smart Citation
“…Our data confirm previous findings showing that maternal HFD feeding during lactation in rodents results in metabolic alterations in the offspring (5, 6, 8, 43). From postnatal d 1 to 21, offspring from HFD‐fed mothers gained 23% more body weight than those from CD‐fed dams (Fig.…”
Section: Resultssupporting
confidence: 92%
“…Maternal obesity results in multiple alterations, most of them unknown, in milk composition, including changes in the lipid profile and in hormone and cytokine levels. Milk from obese humans and rodents has a higher content of long‐chain saturated FA and higher levels of insulin and leptin (3, 7, 8, 46, 5962). PRL is an important regulator of milk composition; it promotes the expression of β‐casein (63), whey acidic protein (64), lactoglobulin (65), and α‐lactalbumin (66), leading, in turn, to increased lactose biosynthesis and milk volume (likely through enhanced production of lactose) (52, 67).…”
Section: Discussionmentioning
confidence: 99%
“…Pups cross-fostered to dams fed a high fat diet during lactation develop symptoms of metabolic disease including hypertension, 89 diet-induced obesity, 90 and insulin resistance. 91 While the mechanisms underlying these findings are poorly understood, dietary-mediated changes to human milk composition likely represent a major contributing factor. Given the significant association between microbiome composition and metabolic disease outcomes, 92 maternal dietary influence on offspring disease outcomes may be partially explained by the dietary modulation of human milk components impacting the offspring gut microbiome.…”
Section: Impact Of Maternal Nutrition During Breastfeedingmentioning
confidence: 99%
“…Rodents raised in small litters (SLs) are consistently overfed during lactation and develop late-onset obesity, hepatic steatosis, insulin resistance, impaired glucose tolerance, and renal and cardiac metabolic alterations (10). The long-term metabolic derangements caused by neonatal overfeeding are likely due to a combination of disturbances in the CNS, which may alter food intake (11)(12)(13), and the peripheral tissues (14)(15)(16)(17).…”
mentioning
confidence: 99%