Postprandial coagulation activation in overweight individuals after weight loss: Acute and long-term effects of a high-monounsaturated fat diet and a low-fat diet

Bladbjerg, Else‐Marie; Larsen, Thomas Meinert; Due, Anette Pia; Jespersen, Jørgen; Stender, Steen; Astrup, Arne

doi:10.1016/j.thromres.2013.12.010

Cited by 16 publications

(5 citation statements)

References 34 publications

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“…These changes combined with a post-prandial increase in serum triglycerides creates a milieu that favors foam cell formation and the development of atherosclerotic plaques[ 19 , 31 , 33 , 34 ]. In the present study, the baseline post-prandial meal response presented outcomes that were consistent with published data from our laboratory and others[ 16 , 18 , 19 , 22 , 31 - 33 , 35 ]. Thus, the present study presented an opportunity to assess if a probiotic intervention would change disease risk biomarkers in a similar manner as endotoxin and triglycerides.…”

Section: Discussionsupporting

confidence: 92%

Oral spore-based probiotic supplementation was associated with reduced incidence of post-prandial dietary endotoxin, triglycerides, and disease risk biomarkers

McFarlin

Henning

Bowman

et al. 2017

WJGP

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AIMTo determine if 30-d of oral spore-based probiotic supplementation could reduce dietary endotoxemia.METHODSApparently healthy men and women (n = 75) were screened for post-prandial dietary endotoxemia. Subjects whose serum endotoxin concentration increased by at least 5-fold from pre-meal levels at 5-h post-prandial were considered “responders” and were randomized to receive either placebo (rice flour) or a commercial spore-based probiotic supplement [Bacillus indicus (HU36), Bacillus subtilis (HU58), Bacillus coagulans, and Bacillus licheniformis, and Bacillus clausii] for 30-d. The dietary endotoxemia test was repeated at the conclusion of the supplementation period. Dietary endotoxin (LAL) and triglycerides (enzymatic) were measured using an automated chemistry analyzer. Serum disease risk biomarkers were measured using bead-based multiplex assays (Luminex and Milliplex) as secondary, exploratory measures.RESULTSData were statistically analyzed using repeated measures ANOVA and a P < 0.05. We found that spore-based probiotic supplementation was associated with a 42% reduction in endotoxin (12.9 ± 3.5 vs 6.1 ± 2.6, P = 0.011) and 24% reduction in triglyceride (212 ± 28 vs 138 ± 12, P = 0.004) in the post-prandial period Placebo subjects presented with a 36% increase in endotoxin (10.3 ± 3.4 vs 15.4 ± 4.1, P = 0.011) and 5% decrease in triglycerides (191 ± 24 vs 186 ± 28, P = 0.004) over the same post-prandial period. We also found that spore-based probiotic supplementation was associated with significant post-prandial reductions in IL-12p70 (24.3 ± 2.2 vs 21.5 ± 1.7, P = 0.017) and IL-1β (1.9 ± 0.2 vs 1.6 ± 0.1, P = 0.020). Compared to placebo post supplementation, probiotic subject had less ghrelin (6.8 ± 0.4 vs 8.3 ± 1.1, P = 0.017) compared to placebo subjects.CONCLUSIONThe key findings of the present study is that oral spore-based probiotic supplementation reduced symptoms indicative of “leaky gut syndrome”.

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Section: Discussionsupporting

confidence: 92%

Oral spore-based probiotic supplementation was associated with reduced incidence of post-prandial dietary endotoxin, triglycerides, and disease risk biomarkers

McFarlin

Henning

Bowman

et al. 2017

WJGP

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“…Some studies have reported that reductions in fibrinogen are correlated with decreasing in fat mass [45]. Fibrinogen is an acute phase protein and its effect may change depending on the host factors [46]. It is possible that inflammatory mechanisms are involved in postprandial coagulation activation.…”

Section: Secondary Outcomesmentioning

confidence: 99%

The alternate-day fasting diet is a more effective approach than a calorie restriction diet on weight loss and hs-CRP levels

Razavi

Parvaresh

Abbasi

et al. 2021

International Journal for Vitamin and Nutrition Research

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Abstract. Background and Objective: The aim of present study was to compare, and determine, the effects of a modified alternate-day fasting diet vs. calorie restriction on inflammatory indices and coagulation factors. Methods: This was a randomized clinical trial consisting of 80 metabolic syndrome patients, who were enrolled and randomly dichotomized into a modified alternate-day fasting diet or calorie restriction group for 4 months. We measured weight, body mass index (BMI), waist circumstance (WC), waist-hip-ratio (WHR) and fat mass as primary outcomes and assessed high sensitivity C-reactive protein (hs-CRP), interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-α) and coagulation factors levels as secondary outcomes before and after intervention. Results: Compared to the calorie restriction diet, following a modified alternate-day fasting diet led to a greater reduction in body weight (kg) (–6.43 ± 4.34 vs –4.11 ± 4.27; P = 0.02), BMI (kg/m2) (–3.19 ± 2.90 vs –1.43 ± 2.72; P = 0.01), fat mass (kg) (–4.88 ± 2.09 vs –3.72 ± 2.43; P = 0.03), WC (cm) (–5.57 ± 5.64 vs –2.32 ± 5.95; P = 0.01) and WHR (–0.05 ± 0.06 vs –0.02 ± 0.07; P = 0.04). Furthermore, a greater change was found in hs-CRP levels (mg/L) (–2.06 ± 1.18 vs –0.97 ± 0.82; P = 0.03), prothrombin time (s) (1.41 ± 2.34 vs –0.41 ± 2.17; P < 0.001), activated partial thromboplastin time (s) (0.26 ± 3.70 vs –1.78 ± 3.56; P = 0.04) in modified alternate-day fasting diet when compared to calorie restriction diet. However, there was no difference in TNF-α or IL-6 and fibrinogen between groups (P > 0.05). Conclusions: These findings suggest that a modified alternate-day fasting diet can be a beneficial alternative for the management of body weight, fat mass and WC as well as hs-CRP and coagulation factors levels among metabolic syndrome patients.

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“…So far, the relationship between D-dimer and dietary habits has not been well investigated, with the exception of a few intervention studies aimed at monitoring the effects of high-fat dietary supplementation on several coagulation factors, including D-dimer. 6 The possible role of dietary habits on D-dimer on an epidemiological level has never been explored. The traditional Mediterranean diet (MD) is a healthy dietary pattern reportedly linked to lower mortality and risk of major chronic disease 7 and is characterized by a wide consumption of plant foods, cereals, legumes, fish, and olive oil.…”

mentioning

confidence: 99%

Higher adherence to the Mediterranean diet is associated with lower levels of D-dimer: findings from the MOLI-SANI study

et al. 2016

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Postprandial coagulation activation in overweight individuals after weight loss: Acute and long-term effects of a high-monounsaturated fat diet and a low-fat diet

Cited by 16 publications

References 34 publications

Oral spore-based probiotic supplementation was associated with reduced incidence of post-prandial dietary endotoxin, triglycerides, and disease risk biomarkers

Oral spore-based probiotic supplementation was associated with reduced incidence of post-prandial dietary endotoxin, triglycerides, and disease risk biomarkers

The alternate-day fasting diet is a more effective approach than a calorie restriction diet on weight loss and hs-CRP levels

Higher adherence to the Mediterranean diet is associated with lower levels of D-dimer: findings from the MOLI-SANI study

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