Postprandial lipemia as an early predictor of cardiovascular complications in childhood obesity

Su, Jenny; Nzekwu, Mary-Magdelene Ugo; Ball, Geoff D.C.; Jetha, Mary; Proctor, Spencer D.

doi:10.1016/j.jacl.2009.02.006

Cited by 10 publications

(8 citation statements)

References 67 publications

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“…However, the increasing prevalence of pediatric overweight and obesity 29 and the notion that obesity in childhood predicts cardiovascular disease, led the focus of attention to preventive early approaches. Some observations have suggested that apoB48 level may be an important clinical indicator of CVD risk in overweight children, even in the presence of normal LDL-C levels 30 .…”

Section: Physiological Factorsmentioning

confidence: 99%

Postprandial lipemia as a cardiometabolic risk factor

Pirillo

Norata

Catapano

2014

Current Medical Research and Opinion

104

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High levels of fasting circulating triglycerides (TG) represent an independent risk factor for cardiovascular disease. In western countries, however, people spend most time in postprandial conditions, with continuous fluctuation of lipemia due to increased levels of TG-rich lipoproteins (TRLs), including chylomicrons (CM), very low density lipoproteins (VLDL), and their remnants. Several factors contribute to postprandial lipid metabolism, including dietary, physiological, pathological and genetic factors. The presence of coronary heart disease, type 2 diabetes, insulin resistance and obesity is associated with higher postprandial TG levels compared with healthy conditions; this association is present also in subjects with normal fasting TG levels. Increasing evidence indicates that impaired metabolism of postprandial lipoproteins contributes to the pathogenesis of coronary artery disease, suggesting that lifestyle modifications as well as pharmacological approaches aimed at reducing postprandial TG levels might help to decrease the cardiovascular risk.

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Section: Physiological Factorsmentioning

confidence: 99%

Postprandial lipemia as a cardiometabolic risk factor

Pirillo

Norata

Catapano

2014

Current Medical Research and Opinion

104

View full text Add to dashboard Cite

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“…The potential impact of the “residual risk” hypothesis is perhaps most appreciated during conditions of increased atherosclerotic risk. For example, subjects with insulin resistance, T1DM, or T2DM showed raised plasma concentrations of fasting remnant lipoproteins and an ensuing impairment in postprandial lipoprotein metabolism [25, 26]. The remnant lipoproteins are able to penetrate arterial tissue and become entrapped within the subendothelial space [27].…”

Section: Residual Risk Of Cardiovascular Disease After Ldl Cholestmentioning

confidence: 99%

Understanding Postprandial Inflammation and Its Relationship to Lifestyle Behaviour and Metabolic Diseases

Klop

Proctor

Mamo

et al. 2012

International Journal of Vascular Medicine

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Postprandial hyperlipidemia with accumulation of remnant lipoproteins is a common metabolic disturbance associated with atherosclerosis and vascular dysfunction, particularly during chronic disease states such as obesity, the metabolic syndrome and, diabetes. Remnant lipoproteins become attached to the vascular wall, where they can penetrate intact endothelium causing foam cell formation. Postprandial remnant lipoproteins can activate circulating leukocytes, upregulate the expression of endothelial adhesion molecules, facilitate adhesion and migration of inflammatory cells into the subendothelial space, and activate the complement system. Since humans are postprandial most of the day, the continuous generation of remnants after each meal may be one of the triggers for the development of atherosclerosis. Modulation of postprandial lipemia by lifestyle changes and pharmacological interventions could result in a further decrease of cardiovascular mortality and morbidity. This paper will provide an update on current concepts concerning the relationship between postprandial lipemia, inflammation, vascular function, and therapeutic options.

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“…The overproduction of remnant lipoproteins has recently been described in a handful of preclinical and clinical studies, suggesting that intestinal adaptations may contribute to whole body cholesterol homeostasis (22). To our knowledge, postprandial metabolism of remnant lipoproteins originating from the intestine has yet to be characterized in young children with obesity who are at increased risk for CVD relative to their normal-weight peers (23). We propose that exploring remnant lipoprotein profiles in paediatrics may offer a unique perspective to better appreciate of potential subclinical CVD risk in young children (12)(13)(14).…”

Section: Introductionmentioning

confidence: 99%

Elevated remnant lipoproteins may increase subclinical CVD risk in pre‐pubertal children with obesity: a case‐control study

et al. 2012

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Elevated apoB48-containing remnant lipoprotein is a stronger biomarker for paediatric CVD risk compared to traditional cholesterol parameters and may be associated with early adaptation of the intestine during obesity. Further investigation of abnormalities associated with the secretion and/or clearance of atherogenic remnant lipoproteins during the postprandial state may yield insight into our understanding of and therapeutic targets for managing risk for CVD in children with obesity.

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Postprandial lipemia as an early predictor of cardiovascular complications in childhood obesity

Cited by 10 publications

References 67 publications

Postprandial lipemia as a cardiometabolic risk factor

Postprandial lipemia as a cardiometabolic risk factor

Understanding Postprandial Inflammation and Its Relationship to Lifestyle Behaviour and Metabolic Diseases

Elevated remnant lipoproteins may increase subclinical CVD risk in pre‐pubertal children with obesity: a case‐control study

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