Postsynaptic blocking of glutamatergic and cholinergic synapses as a common property of Araneidae spider venoms

Usmanov, P. B.; Kalikulov, D; Shadyeva, N G; Nenilin, A B; Tashmukhamedov, B A

doi:10.1016/0041-0101(85)90038-8

Cited by 20 publications

(5 citation statements)

References 6 publications

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“…The venoms of three Argiope species have been analysed, to various degrees: A . lobata (Pallas 1772) [ 106 , 107 ], a species with a near global distribution–although the species delimitation in southern Africa between A . lobata and A .…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…The venoms of three Argiope species have been analysed, to various degrees: A. lobata (Pallas 1772) [106,107], a species with a near global distribution-although the species delimitation in southern Africa between A. lobata and A. australis is not clear [108]; A. aurantia [109] with a continental North American distribution; and A. bruennichi (Scopoli 1772) [110], a Palearctic distributed species. Lu ¨ddecke et al [110] concluded that Argiope bruennichi has a "simple venom", which they hypothesized was because the spider relies on silk, rather than venom, to subdue its prey, as a silk-venom energy trade-off.…”

Section: Plos Onementioning

confidence: 99%

“…Research of Argiope venoms led to the discovery of postsynaptic neurotoxins, termed argiotoxins (neurotoxins that block Glutamate Receptors, GLuRs) [111]. Argiotoxins have since been described from other species that belong to the Araneidae [107,111]. Three patents have been registered based on Argiope venom [112: Table 4]: A. aurantia, "composition comprising toxins that block calcium channels"; A. lobata, "spider toxin that inhibits glutamate receptor", and "toxin to treat cancer".…”

Section: Plos Onementioning

confidence: 99%

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Orb-web spider Argiope (Araneidae) as indigenous arrow poison of G/ui and G//ana San hunters in the Kalahari

Bird

Moeti²,

Hitchcock

et al. 2023

PLoS ONE

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Hunting has been crucial in early human evolution. Some San (Bushmen) of southern Africa still practice their indigenous hunting. The use of poisons is one remarkable aspect of their bow-and-arrow hunting but the sources, taxonomic identifications of species used, and recipes, are not well documented. This study reports on fieldwork to investigate recent indigenous hunting practices of G/ui and G//ana San communities in the Central Kalahari Game Reserve (CKGR), Botswana. Here we discuss their use of spider poison. The hunters use the contents of the opisthosoma (‘abdomen’) of a spider as sole ingredient of the arrow poison and discard the prosoma that contains the venom-glands. Using taxonomic keys, we identified the spider as the garden orb-web spider Argiope australis (Walckenaer 1805) (Araneidae). The hunters’ choice of this species is remarkable given the scientific perception that A. australis is of little medical importance. The species choice raises questions about how the spider fluids could kill game, particularly when the prosoma, which contains the venom glands, is not used. Possibilities include trauma, as a source of pathogens, or abdomen-containing toxins. Based on characteristics of Argiope Audouin 1826, we hypothesize that the choice of this species for arrow poisons might have evolved from the recognition of aposematic signalling or spiritual symbolism. Indigenous knowledge (IK) is an important source for advances in biotechnology but is in decline worldwide. The study contributes to the documentation of the San people, and their ancient IK, which is threatened by marginalization, political pressures, and climate change.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Plos Onementioning

confidence: 99%

Section: Plos Onementioning

confidence: 99%

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Orb-web spider Argiope (Araneidae) as indigenous arrow poison of G/ui and G//ana San hunters in the Kalahari

Bird

Moeti²,

Hitchcock

et al. 2023

PLoS ONE

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“…Because of a format of current publication, biophysical properties of Araneidae venoms need more detailed observation than we would like to present now. It should be mentioned that electrophysiological experiments demonstrated an ability of JSTX-3, NSTX-3, argiopine (argiotoxin 636 ) of binding the glutamate receptors of the post-synaptic membrane, blocking the processes, normally initiated in it by the glutamate [23,69,78,92,93]. JSTX-3 can be accumulated in the area of synaptic contacts [24].…”

Section: Brief Review Of Chemical Composition and Biophysical Propertmentioning

confidence: 99%

Investigation of chemical substances of terrestrial arthropods

Klyuchko

2019

Biol. Stud.

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Klyuchko O.M. Investigation of chemical substances of terrestrial arthropods. Studia Biolo gica, 2019: 13(1); 129-144 • DOI: https://doi.org/10. 30970/sbi.1301.594 Millions of Arthropods are inhabitants of the Earth and some biochemical products which they produce are valuable for human practice. The aim of this work was to summarize current information about chemical substances produced by Arthropods such as venoms, toxins and some other chemical compounds that may be used in practice. Today such products are obtained and purified using standard biochemical methods. In this article, the information about species of the terrestrial Arthropods -producers of substances acting on the nervous system and used in electrophysiological investigations is presented. Some versions of arthropods' toxins classification and the table with Araneids toxins and effects they occur are suggested as well. Main attention was paid to some Araneidae venoms and toxins that block synaptic transmission in glutamatergic synapses. A review of chemical composition and some biophysical properties of such venoms and toxins was suggested and their chemical structures namely of toxins from spiders of Nephila family and toxins from A. lobata venom were described. Some biophysical properties of Araneidae venoms and toxins are characterized. Other components of Arthropods' venoms were also observed. Contemporary applications of such chemical compounds in agriculture and in the environmental monitoring systems were considered as well. The obtained results evidence that the terrestrial Arthropods is a valuable source of chemical compounds for biophysical laboratories and their great potential has to attract more attention of investigators.

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Glutamate

Duce¹

1988

Comparative Invertebrate Neurochemistry

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Postsynaptic blocking of glutamatergic and cholinergic synapses as a common property of Araneidae spider venoms

Cited by 20 publications

References 6 publications

Orb-web spider Argiope (Araneidae) as indigenous arrow poison of G/ui and G//ana San hunters in the Kalahari

Orb-web spider Argiope (Araneidae) as indigenous arrow poison of G/ui and G//ana San hunters in the Kalahari

Investigation of chemical substances of terrestrial arthropods

Glutamate

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