Potent antiplasmodial extracts from Cameroonian Annonaceae

Boyom, Fabrice Fekam; Fokou, Patrick Valère Tsouh; Yamthé, Lauve Rachel Tchokouaha; Mfopa, Alvine Ngoutane; Kemgne, Eugénie Madiesse; Mbacham, Wilfred Fon; Tsamo, Etienne; Zollo, Paul Henri Amvam; Gut, Jiří; Rosenthal, Philip J.

doi:10.1016/j.jep.2011.01.020

Cited by 52 publications

(42 citation statements)

References 23 publications

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“…The results achieved in this investigation indicated that methanol fractions (acetogenin-rich fractions) have the overall best activity against P. falciparum K1. This potency of acetogeninrich fractions has previously been reported (Boyom et al, 2011) in a similar study targeting the Chloroquine-resistant P. falciparum W2 strain. Globally, the observed inhibitory effect of methanolic fractions could be attributed to the presence of acetogenins.…”

Section: Discussionsupporting

confidence: 82%

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In vitro and in vivo antiplasmodial activity of extracts from Polyalthia suaveolens, Uvaria angolensis and Monodora tenuifolia (Annonaceae)

Mfopa¹,

Mbouna²,

Tchokouaha³

et al. 2017

Int. J. Bio. Chem. Sci

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The present study aimed at investigating the in vitro and in vivo susceptibility of malaria parasites to crude extracts and fractions from Polyalthia suaveolens, Uvaria angolensis, and Monodora tenuifolia. The ethanolic extracts were partitioned using water, dichloromethane, hexane, and methanol. The most promising fraction was subjected to column chromatography. The antiplasmodial effect of extracts, fractions and subfractions against P. falciparum Chloroquine resistant (PfK1) strain was determined using SYBR green florescence assay. The promising fraction was assessed for cytotoxicity against Human Foreskin Fibroblast (HFF) cells and further for safety in Swiss albino mice and suppressive effect against P. berghei. The methanol sub-fraction of P. suaveolens [PStw(Ace)] showed the highest potency with IC 50 of 3.24 µg/mL. Sub-fraction PS8 from PStw(Ace) was the most active with IC 50 of 4.42 µg/mL. Oral administration of PStw(Ace) at 5000 mg/kg b.w in mice showed no signs of toxicity. Also, it exerted the highest suppressive effect against P. berghei at 400 mg/kg b.w throughout the 4 days experiment. Overall, the results achieved supported the use of the three plants in the traditional treatment of malaria in Cameroon. More interestingly, the PStw(Ace) fraction might be of interest in future development of an antimalarial phytodrug.

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Section: Discussionsupporting

confidence: 82%

“…However, the methanol (acetogenin-rich) fractions from a closely related species, M. myristica have previously showed moderate antiplasmodial activities with IC 50 values ranging 5.52-9.03 µg/mL (Boyom et al, 2011). Also, recent studies on other Uvaria spp., viz.…”

Section: Discussionmentioning

confidence: 99%

In vitro and in vivo antiplasmodial activity of extracts from Polyalthia suaveolens, Uvaria angolensis and Monodora tenuifolia (Annonaceae)

Mfopa¹,

Mbouna²,

Tchokouaha³

et al. 2017

Int. J. Bio. Chem. Sci

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“…Results from the current study do not support the relatively low antiplasmodial activity (IC50 ≥ 10 μg/ml) reported previously for R. caffra (Clarkson et al, 2004). Boyom et al (2011) reported on the potency of methanol leaf and stem extracts of X. parviflora from Cameroon. In agreement with the results obtained in this study, these extracts showed high in vitro antiplasmodial activity (IC50 ≤ 5 μg/ml).…”

Section: Resultscontrasting

confidence: 99%

In vitro antiplasmodial screening of ethnopharmacologically selected South African plant species used for the treatment of malaria

Bapela

Meyer

Kaiser

2014

Journal of Ethnopharmacology

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Abstract:Ethnopharmacological relevance: The investigated plant species are traditionally used by Venda people of South Africa, in the treatment of malaria and associated symptoms.Aim of the study: To evaluate the in vitro antiplasmodial efficacy and cytotoxic properties of indigenous medicinal plants used by Venda people against malaria. Materials and methods:In vitro antiplasmodial activity and cytotoxic properties were evaluated on twenty indigenous plant species. Ground plant material was extracted in dichloromethane: 50% methanol (1:1). Antiplasmodial activity was evaluated against the chloroquine-sensitive strain of Plasmodium falciparum (NF54). The cytotoxicity of the plant extracts were assessed against mammalian L-6 rat skeletal myoblast cells. The selectivity index (SI) values were then calculated.Results: Of the 43 plant extracts evaluated, 10 exhibited pronounced antiplasmodial activity (IC 50 ≤ 5μg/ml) with good therapeutic indices (SI ≥ 10). Lipophilic plant extracts were relatively more potent than polar extracts. Tabernaemontana elegans Stapf. (Apocynaceae) and Vangueria infausta Burch. subsp. infausta (Rubiaceae) extracts displayed significant antiplasmodial activity (IC 50 < 2 μg/ml). Conclusion:Findings of this study partly support the ethnomedical use of the investigated plant species by Venda people as antimalarial remedies. The study also highlights some of the knowledge gaps that require further phytochemical studies on the specified plant species.

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“…Amongst the extracts with activity, many were volatile extracts from Cleistopholis patens (Boyom et al, 2011b), Xylopia aethiopica, Hexalobus crispiflorus, (Boyom et al, 2003), Xylopia staudtii, Xylopia aethiopica, Xylopia parviflora, Monodora brevipes, Monodora myristica, Polyalthia suaveolens, Annickia chlorantha, Annona senegalensis (Boyom, 2004). Non-volatile extracts from Annickia chlorantha, Annona muricata, Anonidium mannii, Monodora myristica, Polyalthia suaveolens, Uvaria banmanni, Xylopia aethiopica, and Xylopia parviflora also showed potency against Plasmodium falciparum in vitro (Boyom et al, 2009(Boyom et al, , 2011a. Some of these Annonaceae species from different origins were also investigated for antimalarial activity, including Annona muricata (Leaman et al, 1995;Bidla et al, 2004), Annona squamosa (Bagavan et al, 2011;Johns et al, 2011), Xylopia sp.…”

Section: Discussionmentioning

confidence: 99%

“…In daily practice, the huge majority of the Cameroonian people recognizes and utilizes the properties of several plants to combat malaria and other diseases (Tsabang, 2008). Amongst these, current trends indicate that the Annonaceae are increasingly used and have been proved to be promising source of antimalarial agents (Boyom et al, 2003(Boyom et al, , 2009(Boyom et al, , 2011aBoyom, 2004).…”

Section: Introductionmentioning

confidence: 99%

Ethnopharmacological survey of Annonaceae medicinal plants used to treat malaria in four areas of Cameroon

Tsabang

Fokou

Tchokouaha

et al. 2012

Journal of Ethnopharmacology

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Potent antiplasmodial extracts from Cameroonian Annonaceae

Cited by 52 publications

References 23 publications

<i>In vitro</i> and <i>in vivo</i> antiplasmodial activity of extracts from <i>Polyalthia suaveolens, Uvaria angolensis and Monodora tenuifolia</i> (Annonaceae)

<i>In vitro</i> and <i>in vivo</i> antiplasmodial activity of extracts from <i>Polyalthia suaveolens, Uvaria angolensis and Monodora tenuifolia</i> (Annonaceae)

In vitro antiplasmodial screening of ethnopharmacologically selected South African plant species used for the treatment of malaria

Ethnopharmacological survey of Annonaceae medicinal plants used to treat malaria in four areas of Cameroon

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