Potential antioxidant and cytoprotective effects of essential oil extracted from Cymbopogon citratus on OxLDL and H 2 O 2 LDL induced Human Peripheral Blood Mononuclear Cells (PBMC)

Jamuna, Sanker; Sadullah, Sakeena Sadullah Mohammed; Ashokkumar, R.; Shanmuganathan, Gokul; Mozhi, Senguttuvan Sivan; Devaraj, S. Niranjali

doi:10.1016/j.fshw.2017.02.001

Cited by 24 publications

(6 citation statements)

References 33 publications

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“…The results of this study show that the reducing power and antioxidant potential of EOCC (IC50 = 73.16±12.89 μg/mL) is a viable candidate for anti-inflammatory and antioxidant therapy comparable to that of standard vitamin C (Lascorbic acid), suggesting its role in free radical inhibition as a proton donator. These findings are in consonance with previous studies (Hasim et al, 2015;Jamuna et al, 2017;Salaria et al, 2020). The antioxidant properties of EOCC are ascribable to phytochemicals with redox potential such as phenolic compounds (Unuigbe et al, 2019), flavonoids, alkaloids and sulphides (Hasim et al, 2015).…”

Section: In Vitro Antioxidant Activities Of Eoccsupporting

confidence: 90%

“…Our study shows significant levels of citral in EOCC, suggesting the suitability of EOCC as a preventive and therapeutic anti-inflammatory agent. Antioxidant phytochemicals perform vital functions against age-related ailments, including cancer, high blood pressure and cardiovascular disease, either by stimulating the release of endogenous antioxidants or acting directly to scavenge reactive oxygen species and free radicals (Jamuna et al, 2017). The results of this study show that the reducing power and antioxidant potential of EOCC (IC50 = 73.16±12.89 μg/mL) is a viable candidate for anti-inflammatory and antioxidant therapy comparable to that of standard vitamin C (Lascorbic acid), suggesting its role in free radical inhibition as a proton donator.…”

Section: In Vitro Antioxidant Activities Of Eoccmentioning

confidence: 99%

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Essential Oil of Cymbopogon Citratus Grown in Umuahia: A Viable Candidate for Anti-Inflammatory and Antioxidant Therapy

Onyedikachi

Awah

Chukwu

et al. 2021

Acta Universitatis Cibiniensis. Series E: Food Technology

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The essential oils of Cymbopogon citratus (EOCC) has found use in medicine, food and chemical industry. This study attempts to provide evidence of its suitability for antioxidant and anti-inflammatory therapy. Total phenol and total flavonoid of EOCC was 49.83±0.39mg GAE/g of extract and 352.82±3.45 µg QEC/g of extract respectively. Gas chromatography-mass spectrometry (GC-MS) analysis of its essential oil (EOCC) showed 25 peaks with myrcenyl acetate (9.703%), caryophyllene (8.997%), citronella (6.383%) been the most abundant. The in vitro anti-inflammatory assay using human red blood cell (HRBC) membrane stabilization shows that at 200µg/mL, the percentage inhibition of EOCC was significantly higher compared to diclofenac both for heat-induced and hypotonic induced haemolysis. 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) assays showed a comparable and dose-dependent increase from 50 to 400 μg/mL in relation to vitamin C. Half maximal inhibitory concentration (IC50) of EOCC (73.16±12.89 μg/mL and 656.01±0.01 μmol Fe (II)/L) was remarkably higher compared to that of vitamin C (69.09±4.52 μg/mL and 246.79±0.01 μmol Fe (II)/L) both for DPPH and FRAP assays respectively. In conclusion, results from this study establish preliminary evidence on the therapeutic potential of EOCC in managing inflammation and oxidative stress caused by free radicals.

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Section: In Vitro Antioxidant Activities Of Eoccsupporting

confidence: 90%

Section: In Vitro Antioxidant Activities Of Eoccmentioning

confidence: 99%

Essential Oil of Cymbopogon Citratus Grown in Umuahia: A Viable Candidate for Anti-Inflammatory and Antioxidant Therapy

Onyedikachi

Awah

Chukwu

et al. 2021

Acta Universitatis Cibiniensis. Series E: Food Technology

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“…The antioxidant activity against DPPH of the EOCc was slight (IC 50 = 48 mg/mL), which is close to the result of the study of a sample from Minas Gerais (Brazil) that showed a minor inhibitory effect in DPPH radical assay [36]. However, various results have been reported with samples from other places; such as India, 69% of inhibition at 0.1 mg/mL of concentration; West Africa, 67.6% at 8 mg/mL; Egypt, IC 50 = 1 mg/mL, and Saudi Arabia, IC 50 = 6.9 mg/mL [37]. On the other hand, in this study, carvacrol showed antioxidant activity with an IC 50 = 145 µg/mL (Figure 2).…”

Section: Discussionmentioning

confidence: 99%

The Essential Oil of Cymbopogon citratus Stapt and Carvacrol: An Approach of the Antitumor Effect on 7,12-Dimethylbenz-[α]-anthracene (DMBA)-Induced Breast Cancer in Female Rats

et al. 2020

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C. citratus essential oil and carvacrol have shown an antitumor effect on breast tumor cell lines; the main objective of this research was to evaluate the antitumor effect of the essential oil of Cymbopogon citratus (EOCc) and carvacrol on 7,12-dimethylbenz [a] anthracene (DMBA)-induced breast cancer in female rats. Cancer was induced by a single administration of DMBA at dose of 80 mg/kg body weight (BW). A total of 54 female Holtzman rats were randomly assigned into 9 groups (n = 6). Group I: PS (Physiological saline); Group II: DMBA; Groups III, IV, and V: DMBA + EOCc at doses of 50, 100 and 200 mg/kg/day BW, respectively; Groups VI, VII, and VIII: DMBA + carvacrol at doses of 50, 100 and 200 mg/kg/day BW, respectively; and group IX: DMBA + EOCc + carvacrol at doses of 100 mg/kg/day BW. The treatment lasted 14 weeks. As results, EOCc showed a reduction in tumors as well as necrosis and mitosis. Animals treated with carvacrol did not show necrosis, mitosis, or infiltration. Carvacrol at dose of 100 mg/kg/day BW revealed a significant decrease in the cumulative tumor volume down to 0.11 ± 0.05 cm3 compared to 0.38 ± 0.04 cm3 of the DMBA group (p < 0.01). It is concluded that EOCc and carvacrol had an antitumor effect on DMBA-induced breast cancer in female rats.

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“…C-H stretching of alkane was observed at 2923.029 (CNPs), 2925.80 (Plant extract) corresponding to an alkyl saturated aliphatic group. Peak at 2849.921 (CNPs), 2854.73 (Plant extract) related to symmetric and asymmetric stretching of CH 2 , presence of similar carbon stretch was reported by Wany et al (2014) and Jamuna et al (2017). Observed spectra within 1400–1000 range correspond to N-H stretch of amines (1° and 2°) and C-O stretch (groups of polyphenols like flavanoid, terpenoids and polysaccharides) (Vankar and Shukla, 2012).…”

Section: Resultsmentioning

confidence: 68%

Analytical Investigation of Cymbopogon citratus and Exploiting the Potential of Developed Silver Nanoparticle Against the Dominating Species of Pathogenic Bacteria

et al. 2019

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Indian biodiversity is a hub for medicinal plants. Extensive research has been carried out to select plants with numerous properties which can be used for human welfare. Present research is about Cymbopogon citratus , an economically valuable medicinal plant. In this study Cymbopogon citratus was elected as a subject plant over the five selected plants ( Azadirachta indica , Plumeria obtuse , Sapindus mukorossi , Capsicum annuum and Phyllanthus emblica ) on the basis of antibacterial effect against dominating pathogenic species of gram positive ( Bacillus cereus, Bacillus licheniformis ) and gram negative ( Pseudomonas aeruginosa, Escherichia coli ) bacteria. Further, bioactive agents behind antibacterial potential of Cymbopogon citratus was analyzed using analytical method (Phyto-chemical, FTIR, NMR and GC-MS). Due to the broad antimicrobial spectrum, silver nanoparticles have turned into a noteworthy decision for the improvement of new medication. Therefore, this investigation further elaborated in the development of Cymbopogon citratus silver nano-particles (CNPs). Antibacterial potential of CNPs examine in a range of C 25 –C 150 (μg/ml) through minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) where, C 25 (μg/ml) concentration of CNPs were recorded as the MIC for all bacterial species and C 25 (μg/ml) and C 50 (μg/ml) noted as the MBC for Pseudomonas aeruginosa, Escherichia coli and Bacillus cereus, Bacillus licheniformis , respectively. In agar disk diffusion assay of CNPs, maximum diameter of zone of inhibition was observed for C 150 (μg/ml) concentration Bacillus cereus (20.12 ± 0.42), Bacillus licheniformis (22.34 ± 0.4), Pseudomonas aeruginosa (35.23 ± 0.46) and Escherichia coli (31.87 ± 0.24). Involvement of bioactive component as a reducing and capping agent can be confirmed through FTIR spectrum of CNPs. Moreover XRD, EDXRF and SEM showed crystalline and cuboidal nature of CNPs with ∼ 35 nm sizes. Prominently, cytotoxic analysis was conducted to understand the toxic effect of CNPs. This research highlights the potential of CNPs due to the bioactive components present in Cymbopogon citratus extract: Polyphenols (phenol; 1584.56 ± 16.32 mg/L, Flavanoids) and mixture of terpenoids (Citral, Myrcene, Farnesol, β-myrcene and β –Pinene)

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Potential antioxidant and cytoprotective effects of essential oil extracted from Cymbopogon citratus on OxLDL and H 2 O 2 LDL induced Human Peripheral Blood Mononuclear Cells (PBMC)

Cited by 24 publications

References 33 publications

Essential Oil of Cymbopogon Citratus Grown in Umuahia: A Viable Candidate for Anti-Inflammatory and Antioxidant Therapy

Essential Oil of Cymbopogon Citratus Grown in Umuahia: A Viable Candidate for Anti-Inflammatory and Antioxidant Therapy

The Essential Oil of Cymbopogon citratus Stapt and Carvacrol: An Approach of the Antitumor Effect on 7,12-Dimethylbenz-[α]-anthracene (DMBA)-Induced Breast Cancer in Female Rats

Analytical Investigation of Cymbopogon citratus and Exploiting the Potential of Developed Silver Nanoparticle Against the Dominating Species of Pathogenic Bacteria

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