Potential benefits of L. acidophilus in dyslipidemic rats

Abstract

Several studies have shown that probiotics and synbiotics ameliorate dyslipidemia. However, the molecular mechanisms mediating their effects remain to be determined. Therefore, we aimed to compare the effects of a probiotic, a prebiotic, and a synbiotic in dyslipidemic Sprague–Dawley rats, and explore the mechanisms involved using a proteomic approach. The rats were allocated to five groups: a control group that was fed normal chow, and four high-fat diet-fed groups, three of which were administered a probiotic (Lactobacillus acidophilus), a prebiotic (inulin), or a combination of the two (a synbiotic) for 30 days. We showed that the administration of inulin, and especially L. acidophilus, improved the lipid profile and reduced the serum concentrations of inflammatory markers in high-fat diet-fed rats. Proteomic analysis showed changes in lipid elongation, glycerolipid metabolism, activation of antioxidants, and a reduction in the activation of the mitogen-activated protein kinase signaling pathway in the livers of rats administered L. acidophilus, which likely mediate its beneficial effects on inflammation and dyslipidemia by reduced the levels of 18.56% CRP, 35.71% TNF-α 25.6% LDL-C and 28.57% LDL-C/HDL-C ratio when compared to HF group. L. acidophilus and inulin may represent effective natural means of maintaining inflammation and dyslipidemia.

Electronic and Conventional Cigarette Exposure Aggravate Metabolic Parameters in High-Fat Diet-Induced Rats

“…HFD formulated from a mixture of oxidized palm oil and quail egg yolk is revealed to cause profile lipid impairment, increased glucose, uric acid, urea, creatinine, AST, and ALT levels; this finding was in line with previous studies [3], [4], [5]. It is also well known to promote the development of metabolic syndrome, atherosclerosis, and cardiovascular disease through ROS and inflammation [21], [22]. Meanwhile, cigarettes and e-cigarette exposure aggravated the HFD negative effect.…”

“…HFD administration is associated with lipid profile impairment and contributes to cardiovascular disease development [21], [22]. In the present study, cigarettes and e-cigarettes exposure for 6 weeks aggravated lipid profile impairment in rats previously administered HFD formulated of the mixture of oxidized palm oil and quail egg yolk.…”

Physicochemical and Functional Characterization of Newly Designed Biopolymeric-Based Encapsulates with Probiotic Culture and Charantin

“…Free cells demonstrated a lipase activity of (42%), which was in agreement with previous studies reporting that lactic acid bac-teria, among which is L. acidophilus, demonstrated pancreatic lipase inhibitory activities in vivo [65]. Reamtong et al [66] found that probiotic L. acidophilus improved the lipid profile in high-fat diet-fed rats. Their study revealed that lipase expression was downgraded in high-fat diet rats fed with probiotic L. acidophilus.…”

Effects of probiotic Lactiplantibacillus plantarum IMC 510 supplementation on metabolic factors in otherwise healthy overweight and obese individuals

“…plantarum IMC 510 can improve the blood parameters and suggest that its benefits are possibly limited in subjects showing haematologic alterations. Notably, a large number of studies showed that certain probiotics may be able to lower glycaemia and serum lipids, particularly in diabetic or hypercholesterolemic subjects in clinical (Jones et al, 2012; Khalili et al, 2022; Kocsis et al, 2020; Wang et al, 2018; Wu et al, 2017; Zhang et al, 2022) and in pre‐clinical research (Cabello‐Olmo et al, 2022; Marques et al, 2020; Ooi & Liong, 2010; Reamtong et al, 2021; Wang et al, 2012). Notably, last year, three probiotics were tested in a healthy rabbit (see details in Kadja et al, 2021) and improved the biochemical and haematological profiles.…”