Potential Cardioprotective Effects of Sumac Capsule in Patients With Hyperlipidemia: A Triple-Blind Randomized, Placebo-Controlled Crossover Trial

Asgary, Sedigheh; Salehizadeh, Leila; Keshvari, Mahrokh; Taheri, Marzieh; Spence, Nicholas; Farvid, Maryam S.; Rafieian-Kopaei, Mahmoud; Sarrafzadegan, Nizal

doi:10.1080/07315724.2017.1394237

Cited by 32 publications

(40 citation statements)

References 27 publications

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“…The biochemical biomarkers were adjusted for mean change of energy intake and physical activity (Table 5). (Ardakani, Vahidi, Karimi-Nazari, Dehghani, & Nadjarzadeh, 2016;Ardalani et al, 2016;Asgary et al, 2018;Heydari et al, 2019;Jaradat et al, 2017). In accordance with this study, the beneficial effects of sumac on weight and BMI were previously observed among hyperlipidemic obese (Asgary et al, 2018) and overweight or obese individuals (Heydari et al, 2019).…”

Section: Effects On Biochemical Assessmentssupporting

confidence: 86%

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The beneficial effects of sumac (Rhus coriaria L.) supplementation along with restricted calorie diet on anthropometric indices, oxidative stress, and inflammation in overweight or obese women with depression: A randomized clinical trial

Hariri

Ghahroudi

Jahangiri³

et al. 2020

Phytotherapy Research

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Background: Oxidative stress and inflammation play pivotal roles in the pathophysiology of obesity and depression. This study aimed to evaluate the effects of sumac (Rhus coriaria L.) on anthropometric indices, oxidative stress, inflammation, and depression in overweight or obese depressed women. Methods: This randomized, double-blind, placebo-controlled clinical trial was conducted on overweight or obese women aged 20-65 years with mild to moderate depression. The participants (n = 62) were assigned to receive a restricted calorie diet (RCD) plus 3 g/day of either sumac or placebo for 12 weeks. Anthropometric measurements, biochemical biomarkers, and the Beck depression inventory were assessed during the study. Results: Sumac significantly reduced weight, body mass index, body fat (p < .001), visceral fat level (p = .03), waist and hip circumference, and malondialdehyde levels (p = .03, p = .002, and p = .006, respectively) in comparison with the placebo group. The levels of interleukin-6 and tumor necrosis factor-α decreased only in the sumac group (11 and 32%, respectively); however, these reductions were not significant. The high-sensitivity c-reactive protein levels (p = .007 and p = .01, respectively) and Beck scores (p < .001) decreased significantly in both the sumac and the placebo group without any significant difference between the two groups. Conclusion: Sumac can be considered as a functional food that along with RCD could have beneficial effects on obesity management, through the possible modulatory effects on oxidative stress in overweight or obese depressed women.

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Section: Effects On Biochemical Assessmentssupporting

confidence: 86%

“…could not find any significant changes in hyperlipidemic patients after supplementation with 1,000 mg/day sumac powder for 4 weeks (Asgary et al, 2018). In the current study, body fat and visceral fat level also reduced significantly after sumac supplementation along with RCD.…”

Section: Discussionmentioning

confidence: 84%

The beneficial effects of sumac (Rhus coriaria L.) supplementation along with restricted calorie diet on anthropometric indices, oxidative stress, and inflammation in overweight or obese women with depression: A randomized clinical trial

Hariri

Ghahroudi

Jahangiri³

et al. 2020

Phytotherapy Research

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“…The study indicated that short term supplementation with R. coriaria fruit capsules (500 mg, twice daily) can effectively improve blood pressure, endothelial functions and hyperlipidemia in patients with hypercholesterolemia. It was also noticed that sumac augmented the effects of antihypertensive and antihyperlipidemic drugs in dyslipidemic patients without any serious side effects and indicated that the plant is an effective therapeutic adjuvant . A summary of the recently published information about the biological activities in literature is illustrated in Table .…”

Section: Bioactivity Studiesmentioning

confidence: 99%

Phytochemical Diversity and Pharmacological Properties of Rhus coriaria

Elagbar

Shakya

Barhoumi

et al. 2020

Chemistry & Biodiversity

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Rhus coriaria L. (Anacardiaceae), sumac, is a common condiment, appetizer and souring agent in the Mediterranean region that has a long history in traditional medicine. R. coriaria has been prescribed for the treatment of many ailments including diarrhea, ulcer, hemorrhoids, hemorrhage, wound healing, hematemesis, and eye ailments like ophthalmia and conjunctivitis. The plant is also used as diuresis, antimicrobial, abortifacient and as a stomach tonic. Sumac is known to be rich in different classes of phytochemicals including tannins, polyphenols, flavonoids, organic acids and essential oils and continues to be a hot topic for extensive research work designed for revealing its phytochemical constituents and evaluating its bioactive properties. This review summarizes the recent phytochemical and diverse bioactivity studies on R. coriaria, especially those concerned with antitumor, antioxidant, hypoglycemic, antimicrobial, and anti-inflammatory studies.

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“…The red fruits of sumac are used as a very popular spice in Persian countries, either in their pure form or in combination with other spices, due to their sour lemon taste. According to the literature, sumac fruits possess a multitude of biological activities, including beneficial effects in vivo in streptozotocin-induced diabetes [23], lipid-lowering effects in hypercholesterolemic rats [24], cardioprotective effects in hyperlipidemic patients [25], and prevention of necrotizing enterocolitis [26]. Recently, our group demonstrated the beneficial effect of Rhus coriaria L. fruit extracts as preventive agents in the treatment of keratinocyte inflammation through their inhibition of skin pro-inflammatory mediators, including IL-8, MMP-9, ICAM-1, and VEGF [27].…”

Section: Recent Advances On the Role Of Polyphenols In Inflammatory Cmentioning

confidence: 99%

Special Issue: Anti-Inflammatory Activity of Plant Polyphenols

Sangiovanni

Dell’Agli

2020

Biomedicines

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Potential Cardioprotective Effects of Sumac Capsule in Patients With Hyperlipidemia: A Triple-Blind Randomized, Placebo-Controlled Crossover Trial

Abstract: Sumac consumption may decrease cardiovascular risk factors in persons with mild to moderate hyperlipidemia.

Cited by 32 publications

References 27 publications

The beneficial effects of sumac (Rhus coriaria L.) supplementation along with restricted calorie diet on anthropometric indices, oxidative stress, and inflammation in overweight or obese women with depression: A randomized clinical trial

The beneficial effects of sumac (Rhus coriaria L.) supplementation along with restricted calorie diet on anthropometric indices, oxidative stress, and inflammation in overweight or obese women with depression: A randomized clinical trial

Phytochemical Diversity and Pharmacological Properties of Rhus coriaria

Special Issue: Anti-Inflammatory Activity of Plant Polyphenols

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