Potential <i>in vivo</i> delivery routes of postbiotics

Abbasi, Amin; Hajipour, Neda; Hasannezhad, Paniz; Baghbanzadeh, Amir; Aghebati‐Maleki, Leili

doi:10.1080/10408398.2020.1865260

Cited by 38 publications

(17 citation statements)

References 187 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Also, different methods of preparing food or cooking should be implemented at temperatures above 60°C for at least 30 minutes. Besides, according to the positive effect of some food-based bioactive components in the reduction of viral (COVID-19) invasion to target sites hence, it is suggested that foods containing active elements such as postbiotics and probiotics can be used daily, as the role of these compounds in strengthening the immune system has been fully demonstrated [99,100].…”

Section: N Novel Food Processing Methods Utilized To Reduce Viral Loadmentioning

confidence: 99%

Can food matrices be considered as a potential carrier for COVID-19?

et al. 2022

View full text Add to dashboard Cite

Humanity is currently facing a life-threatening challenge from the infectious and epidemic disease SARS-CoV-2. To date, the various modes of transmission of the virus have not been fully elucidated. In this regard, there is a possibility of transmission of the virus through food products. The COVID-19 pandemic disease, like those associated with SARS and MERS, is transmitted mainly through the respiratory tract and airborne aerosol particles, but the presence of fragments of the genetic virus (RNA) in the feces of numerous patients proposes that their fecal-oral pathway may be expanded. In addition, people with gastrointestinal disorders such as atrophic gastritis and metaplasia may be susceptible to COVID-19 infection. Accordingly, food may act as a potential carrier of COVID-19 due to environmental or cross-contamination. According to the available evidence, the spread and possibility of transmission of COVID-19 contamination from humans to food SUMMARY products are possible. Beyond that, there is some evidence that some food sources of animal origin, such as pigs and rabbits, can be contaminated by COVID-19. Therefore, the transmission of the virus through some meat products may be conceivable. Due to the rapid release rate of COVID-19 and its stability in various milieus, especially food manufacturing circumstances, it may enter the matrix during different stages of traditional or industrial food processing. Therefore, preventive measures are recommended to be utilized in the food manufacturing sector. The present study explored the risk of different food matrices, including dairy products, bread, meat and meat products, vegetables, fruits, and processed foods, as potential carriers for the transmission of COVID-19.

show abstract

Section: N Novel Food Processing Methods Utilized To Reduce Viral Loadmentioning

confidence: 99%

Can food matrices be considered as a potential carrier for COVID-19?

et al. 2022

View full text Add to dashboard Cite

show abstract

“…The breakthroughs in microtechnology and especially nanotechnology, and the availability of a number of platforms in the nanometer size range have brought about revolutionary innovations in biological research techniques and medical practice. Targeted delivery systems based on nanoparticles, for example, and various carrier systems have been described for targeted delivery or/and release of postbiotics in various in vivo models [ 16 ]. However, significant pharmaceutical advances are needed for the oral and lung delivery of postbiotics.…”

Section: Tissue-specific Drug Deliverymentioning

confidence: 99%

Turning Microbial AhR Agonists into Therapeutic Agents via Drug Delivery Systems

et al. 2023

View full text Add to dashboard Cite

Developing therapeutics for inflammatory diseases is challenging due to physiological mucosal barriers, systemic side effects, and the local microbiota. In the search for novel methods to overcome some of these problems, drug delivery systems that improve tissue-targeted drug delivery and modulate the microbiota are highly desirable. Microbial metabolites are known to regulate immune responses, an observation that has resulted in important conceptual advances in areas such as metabolite pharmacology and metabolite therapeutics. Indeed, the doctrine of “one molecule, one target, one disease” that has dominated the pharmaceutical industry in the 20th century is being replaced by developing therapeutics which simultaneously manipulate multiple targets through novel formulation approaches, including the multitarget-directed ligands. Thus, metabolites may not only represent biomarkers for disease development, but also, being causally linked to human diseases, an unexploited source of therapeutics. We have shown the successful exploitation of this approach: by deciphering how signaling molecules, such as the microbial metabolite, indole-3-aldehyde, and the repurposed drug anakinra, interact with the aryl hydrocarbon receptor may pave the way for novel therapeutics in inflammatory human diseases, for the realization of which drug delivery platforms are instrumental.

show abstract

“…Furthermore, today postbiotics are also produced in a laboratory method. These methods include high pressure, thermal treatment, sonication and ionizing radiation (Abbasi et al, 2020; Aghebati Maleki, Samadi Kafil, et al, 2021). These compounds have positive antimicrobial, anticancer, immunomodulation, antioxidant, antihypertensive, cholesterol‐lowering and antiproliferative properties (Fathi‐Zavoshti et al, 2020; Hosseini et al, 2021).…”

Section: Postbioticsmentioning

confidence: 99%

Postbiotics as potential promising tools for SARS-CoV-2 disease adjuvant therapy

Khani

Soleimani

Noorkhajavi

et al. 2022

Journal of Applied Microbiology

Self Cite

View full text Add to dashboard Cite

The SARS-CoV-2 pandemic defines the global health tension of our time. There are several continuous efforts to find a definitive cure in this regard. According to some adverse effects and problems of customary SARS-CoV-2 disease therapies, bioactive compounds, for example probiotics-derived metabolites (postbiotics) have been accomplishing supreme importance by investigators for adjuvant cures in patients with SARS-CoV-2. Postbiotics inhibit angiotensin-converting enzyme 2 activity and stimulate the immune system. They also boost the SARS-CoV-2 disease treatment effectiveness and reduce its adverse effects in SARS-CoV-2 illness patients as a result of antiviral and anti-inflammatory effects. Furthermore, postbiotics having unique features such as high safety, high shelf life and stability to the gastrointestinal tract can be utilized as hopeful instruments for both adjuvant and inhibition strategies in SARS-CoV-2 patients with no earnest unfavourable adverse effects. The concept of postbiotics and their biocompatible characteristics are comprehensively discussed in the present review while highlighting the bilateral relationship between postbiotic biometabolites and respiratory tract infection with a special look at the potential biological role in the inactivation of SARS-CoV-2 and reduction of related inflammatory pathways.

show abstract

Potential in vivo delivery routes of postbiotics

Cited by 38 publications

References 187 publications

Can food matrices be considered as a potential carrier for COVID-19?

Can food matrices be considered as a potential carrier for COVID-19?

Turning Microbial AhR Agonists into Therapeutic Agents via Drug Delivery Systems

Postbiotics as potential promising tools for SARS-CoV-2 disease adjuvant therapy

Contact Info

Product

Resources

About