The SARS-CoV-2 pandemic defines the global health tension of our time. There are several continuous efforts to find a definitive cure in this regard. According to some adverse effects and problems of customary SARS-CoV-2 disease therapies, bioactive compounds, for example probiotics-derived metabolites (postbiotics) have been accomplishing supreme importance by investigators for adjuvant cures in patients with SARS-CoV-2. Postbiotics inhibit angiotensin-converting enzyme 2 activity and stimulate the immune system. They also boost the SARS-CoV-2 disease treatment effectiveness and reduce its adverse effects in SARS-CoV-2 illness patients as a result of antiviral and anti-inflammatory effects. Furthermore, postbiotics having unique features such as high safety, high shelf life and stability to the gastrointestinal tract can be utilized as hopeful instruments for both adjuvant and inhibition strategies in SARS-CoV-2 patients with no earnest unfavourable adverse effects. The concept of postbiotics and their biocompatible characteristics are comprehensively discussed in the present review while highlighting the bilateral relationship between postbiotic biometabolites and respiratory tract infection with a special look at the potential biological role in the inactivation of SARS-CoV-2 and reduction of related inflammatory pathways.

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Food degradation made by mycotoxigenic molds represents a significant challenge too food security. Postbiotics are associated with soluble compounds liberated by living bacterial cells or their construction release after lysis, and these metabolites offer the host biological action and specific physiological benefits. In this work, the postbiotics from tree strains of Lactobacillus spp. (Limosilactobacillus reuteri ATCC 367, Lacticaseibacillus casei431and Limosilactobacillus reuteri ATCC) were lyophilized, filtered, and tested to evaluate the antimicrobial and anti-biofilm activity in vitro and milk against P. expansoum. Also, to assess the antioxidant efficacy and the free radical scavenging possibility of the postbiotic, DPPH and ABTS + methods were used. Antimicrobial activity and biofilm removal activity of postbiotics depended on the Lactobacillus strains used. The minimum inhibitory concentration (MIC) of the prepared postbiotic was determined to be 70ug/ml. The lowest minimum effective concentration (MEC) of postbiotics were significantly differed, in the food matrix, and a low MEC index (100 mg/ml) was detected for postbiotic of L. brevis. Postbiotics derived from L. brevis showed the highest antimicrobial activity compared to L. casei and L. reuteri. The postbiotic extracted from Lactobacillus strain may have functional properties (potential antimicrobial and anti-biofilm) in vitro and food models.

In recent years, the field of probiotics and postbiotics has attracted the attention of many. On the one hand, probiotics when administered in adequate amounts, confer a range of a health benefits on the host but concerns have been reported about the administration of live microorganism and its associated risks. On the other hand, postbiotics with desirable traits as inactivated microbial cells or cell fractions, could non-cytotoxically benefit the consumer when ingested in sufficient amounts. In this document authors have attempted to question and answer the protentional of postbiotic as safe alternatives to live probiotic microbes in functional foods, nutraceuticals, and pharmaceutical products.

Maternal postpartum depression, one of the most prevalent and incapacitating side effects of motherhood, is frequently underdiagnosed and undertreated. However, treatment results are still far from ideal. It has recently come to light that dietary changes are linked to changes in gut flora, which raises health risks and makes people more susceptible to a number of diseases. The gut microbiota plays a significant regulating role in the progression of psychiatric illnesses such postpartum depression. Probiotics and prebiotics have recently acquired popularity in studies on mental health and disease. In this review, the authors explore the connection between postpartum depression and gut microbiota, risk factors and how probiotic bacteria work to lessen symptoms, as well as the possibility of using probiotic bacteria as a useful postpartum depression therapy component.