Potential matrix metalloproteinase inhibitors from edible marine algae: A review

Mushrooms extracts and compounds in cosmetics, cosmeceuticals and nutricosmetics—A review

“…These generated ROS stimulate the mitogen-activated protein kinases, which stimulate the activator protein factor 1 (AP-1) causing uncontrolled expression of MMPs, responsible for collagen degradation and skin wrinkling. Hence, several studies are being conducted in order to find natural inhibitors of AP-1 as cosmeceutical ingredient to inhibit the expression of MMPs (Thomas et al, 2014). Until now very few reports are available on theanti-elastase and anti-collagenase activity of mushroom extracts or their metabolites, but several studies are available in literature for the anti-elastase activity of plant extracts (Thring et al, 2009;Moon et al, 2010;Piwowarski et al, 2011), earthworm extract (Azmi et al, 2014) and marine algae extracts (Thomas et al, 2014).…”

“…Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that degrade the extracellular matrix associated with some pathological and physiological conditions such as inflammatory and vascular diseases, carcinogenesis, wound healing and bone resorption to mention but a few (Thomas et al, 2014). MMP-1 is membrane anchored, being the main metalloproteinase that degrades collagen.…”

“…Hence, several studies are being conducted in order to find natural inhibitors of AP-1 as cosmeceutical ingredient to inhibit the expression of MMPs (Thomas et al, 2014). Until now very few reports are available on theanti-elastase and anti-collagenase activity of mushroom extracts or their metabolites, but several studies are available in literature for the anti-elastase activity of plant extracts (Thring et al, 2009;Moon et al, 2010;Piwowarski et al, 2011), earthworm extract (Azmi et al, 2014) and marine algae extracts (Thomas et al, 2014). Kim et al (2014) reported the anti-collagenase and anti-elastase activity of mycelial extract from Tricholoma matsutake (S. Ito & S. Imai) Singer by treating dermal fibroblast cells with T. matsutake extract at concentrations of 1-100 g/mL for 72 h followed by analysis of elastase, MMPs and type 1 collagen expression.…”

Marine Pharmacology in 2014–2015: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, Antiviral, and Anthelmintic Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

“…(g) Nervous system marine pharmacology: astaxanthin as a potential neuroprotective agent [342]; origin, distribution, toxicity, and therapeutic uses of the marine neurotoxin tetrodotoxin [343]; marine natural products with neuroprotective activity [344]; marine-terpenoid gracilins as promising compounds for Alzheimer's disease [345]; new marine drugs for Alzheimer's disease treatment [346]. (h) Miscellaneous molecular targets and uses: matrix metalloproteinase inhibitors isolated from edible marine algae [347]; marine natural products that targeting apoptosis signaling pathways [348]; scytonemin and emerging biomedical applications [349]; antiobesity effects of the carotenoid fucoxanthin [350]; therapeutic potential of astaxanthin [351]; pharmacological properties of marine coumarins [352].…”

Marine Pharmaceuticals: A New Wave of Anti-angiogenic Drugs

“…It is also a potent anti-proliferative and anti-angiogenic agent. It has demonstrated significant MMP-2 and MMP-9 inhibitory potential at very low doses [63]. Consequently, Dieckol has great potential to be used as an anti-cancer drug in near future.…”