Potential of Ethanolic Extract from Ripe Musa balbisiana Colla Fruit Using Ultrasound-Assisted Extraction as An Antioxidant and Anti-Gout

Irawan, Candra; Utami, Andita; Styani, Erna; Putri, Imalia Dwi; Putri, Ratna Komala; Dewanta, Avisani; Ramadhanti, Annisa

doi:10.5530/pj.2021.13.168

Cited by 9 publications

(7 citation statements)

References 23 publications

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“…The IC 50 values (the concentration at which 50% of radicals were recovered) of methanol extract in DPPH and ABTS assays were 112.57 μg/mL and 14.49 μg/mL, respectively 10 Journal of Food Processing and Preservation (Figures 2 and 4). The DPPH radical scavenging activity of extract-enriched polyphenols and saponins was better than that of polyphenols in the ethanolic extract of M. balbisiana fruit with an IC 50 value of 150:24 ± 0:03 mg/mL [31]. The figure for ABTS scavenging activity was greater than that of the extract from banana flesh and plantain flesh in three solvents aqueous, ethanol, and acetone [32].…”

Section: Antioxidant Activities Of the Extractmentioning

confidence: 88%

Phytochemical Screening, Extraction, and Determination of the Bioactivities of the Extract-Enriched Polyphenols and Saponins from Musa balbisiana Fruit

Hoang

Phan

et al. 2023

Journal of Food Processing and Preservation

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Many parts of Musa balbisiana have been used widely in traditional medicine, food, or cosmetic purposes. The present study is aimed at obtaining the extract-enriching bioactive compounds from M. balbisiana and determining the bioactive activities of the extract. Total polyphenols and saponins in the extracts were quantified. The response surface method (RSM) was used to optimize the extraction with methanol support. The optimal extraction conditions were at 120 min in 65°C at the material/solvent ratio of 1/36 ( w / v ). The obtained extract containing 51.72 mg/gGAE of total polyphenols (TPC) and 41.66 mg/g of saponins (TSC) was evaluated for antioxidant, antibacterial, antifungal, and antidiabetic abilities. The extract of M. balbinasia fruit exhibited strong antioxidant activity. The IC50 112.57 μg/mL (DPPH) and 14.49 μg/mL (ABTS). The absorbance of the extract was 1.653 ± 0.030 at 250 ppm (RP assay). The antibacterial and antifungal inhibition exhibited a correlation with TPC and TSC. The extract inhibited Gram (+) S. aureus better than Gram (-) E. coli, while the inhibition percentage (I%) against A. flavus reached over 70% at 800 ppm. The IC50 value of the extract for anti-inflammatory activity was 187.91 μg/mL. The antidiabetic assessment revealed that methanolic extract showed quite strong inhibition with α-amylase (IC50 68.26 μg/mL) and α-glucosidase (IC50 72.61 μg/mL). The results of the study showed that M. balbinasia fruit is a potential source of bioactive phytochemicals, which can be used as a plant-based antioxidant, antibacterial, antifungal, anti-flammatorial, and antidiabetic agent. This is valuable information to support further studies to exploit and apply it in functional food, pharmaceutical, and cosmetic industries.

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Section: Antioxidant Activities Of the Extractmentioning

confidence: 88%

Phytochemical Screening, Extraction, and Determination of the Bioactivities of the Extract-Enriched Polyphenols and Saponins from Musa balbisiana Fruit

Hoang

Phan

et al. 2023

Journal of Food Processing and Preservation

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“…Test for antioxidants: the DPPH method refers to the method used by Irawan. 13 An amount of 5 mg of stem bark extract was dissolved with methanol pa in a 5 mL measuring flask, resulting in a sample solution with a concentration of 1,000 mg/L. DPPH 39 mg/L solution was added to five 5 mL measuring flasks, then each was put into five 5 mL measuring flasks, then each was added 2 mL of DPPH 39 mg/L solution, then measured with methanol pa, and homogenized (sample concentrations of 40, 80, 160,320 and 640 mg/L).…”

Section: Antioxidant Activity Test Using 11-diphenyl-2-pikrilhidrazil...mentioning

confidence: 99%

Antioxidant Activity of DPPH, CUPRAC, and FRAP Methods, as well as Activity of Alpha-Glucosidase Inhibiting Enzymes from Tinospora crispa (L.) Stem Ultrasonic Extract

Irawan¹,

Putri²,

Sukiman³

et al. 2022

Pharmacogn J.

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Aims:The goal of this work was to get the stem extract of Tinospora crispa (L.) using ultrasoundassisted extraction (UAE) with duration and amplitude changes to achieve optimal extraction conditions. The antioxidant potential of the extract as measured by 2,2-diphenyl-1-picrylhydrazyl (DPPH), CUPRAC (Cupric Ion Reducing Antioxidant Capacity), FRAP (Ferric Reducing Ability of Plasma), and its antidiabetic potential. Results: The third test of antioxidant methods showed that the measurement of antioxidant activity with, DPPH, CUPRAC, and FRAP gave significantly different results, but CUPRAC and FRAP gave the same response to the ethanol extract of Tinospora crispa stems, it can be concluded that the extract of Tinospora crispa stems in all treatments had strong antioxidant activity using either the CUPRAC or methods FRAP. In addition, it is very active as an antidiabetic by inhibiting alpha glucosidase. The optimum extract selected was extract B (extraction time was 35 minutes and amplitude 65%) with IC 50 values for antioxidant activity in the CUPRAC method of 72.53 ± 0.18 mg/L and the FRAP method of 152.29 ± 2.16 mg/L, while the inhibition of alpha glucosidase was 0.30 ± 0.006 mg/L.

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“…The total phenolic content of fruit peel Phaleria macrocarpa was determined using the Folin-Ciocalteu method. 17 The crude extract solution with a concentration of 1000 ppm was pipetted as much as 400 µL and put into a measuring flask with a capacity of 10 mL. The solution was added with distilled water up to 5 mL, then shaken until homogeneous, then 1 mL of Folin-Ciocalteu reagent was added and shaken again until homogeneous, then allowed to stand for 3 minutes.…”

Section: Total Phenolic Contentmentioning

confidence: 99%

“…Antioxidant testing of the FRAP method using the procedure that has been used by Irawan et al 17 The work was done on the crude ethanol extracts of treatments A, B, C, and D that were obtained during the extraction process with the UAE. A solution of fruit peel ethanol extract with a concentration range of 40 to 160 mg/L was prepared from a mother liquor of 1000 mg/L fruit peel ethanol extract.…”

Section: Antioxidant Activity Test Using Ferric Reducing Antioxidant ...mentioning

confidence: 99%

Antioxidant Capacity and Potential as an Alpha-Glucosidase Inhibitor in Phaleria macrocarpa (Scheff.) Boerl Fruit Peel Ultrasonic Extract

Irawan¹,

Sukiman²,

Ismail³

et al. 2022

Pharmacogn. J.

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Phaleria macrocarpa (Scheff.) Boerl is native to the tropical region of Papua Island, Indonesia, and has traditionally been used as a herbal drink, either alone or in combination with other medicinal plants, to treat diseases such as cancer, hypertension, and diabetes mellitus. This study aimed to obtain the fruit peel extract of Phaleria macrocarpa (Scheff.) Boerl. through the application of ultrasound-assisted extraction (UAE) with variations in time and amplitude to produce optimal extraction conditions. The potential of the extract as an antioxidant using the cupric ion reducing antioxidant capacity (CUPRAC) and ferric reducing antioxidant power (FRAP) methods, and its potential as an antidiabetic through alpha glucosidase inhibition. The optimum extract selected was extract C (extraction time was 45 minutes and amplitude 60%) with IC 50 values for antioxidant activity in the CUPRAC method of 39.63 ± 0.009 mg/L and the FRAP method of 77.37 ± 0.8 mg/L, while the inhibition of alpha glucosidase was 0.45 ± 0.007 mg/L. It can be concluded that the ethanol extract of Phaleria macrocarpa fruit peel has the potential as a source of antioxidants and anti-diabetic.

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Potential of Ethanolic Extract from Ripe Musa balbisiana Colla Fruit Using Ultrasound-Assisted Extraction as An Antioxidant and Anti-Gout

Abstract: The antioxidant activity found in Musa balbisiana Colla may be related to anti-gout activity, where

Cited by 9 publications

References 23 publications

Phytochemical Screening, Extraction, and Determination of the Bioactivities of the Extract-Enriched Polyphenols and Saponins from Musa balbisiana Fruit

Phytochemical Screening, Extraction, and Determination of the Bioactivities of the Extract-Enriched Polyphenols and Saponins from Musa balbisiana Fruit

Antioxidant Activity of DPPH, CUPRAC, and FRAP Methods, as well as Activity of Alpha-Glucosidase Inhibiting Enzymes from Tinospora crispa (L.) Stem Ultrasonic Extract

Antioxidant Capacity and Potential as an Alpha-Glucosidase Inhibitor in Phaleria macrocarpa (Scheff.) Boerl Fruit Peel Ultrasonic Extract

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