Potential prebiotic activity of <i>Tenebrio molitor</i> insect flour using an optimized <i>in vitro</i> gut microbiota model

Carvalho, Nelson Mota de; Teixeira, Francisco José Soares; Silva, Sara; Madureira, Ana Raquel; Pintado, Manuela

doi:10.1039/c8fo01536h

Cited by 24 publications

(19 citation statements)

References 35 publications

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“…Bifidobacterium and Lactobacillus , found in the human gastrointestinal microbiota, play an essential role in health promotion. Considering bacterial potential beneficial effects, they are often used in probiotic preparations or considered as target microorganisms for prebiotic substrates [ 48 ].…”

Section: Resultsmentioning

confidence: 99%

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Bioactivity and Bioaccessibility of Bioactive Compounds in Gastrointestinal Digestion of Tomato Bagasse Extracts

Damasceno

Oliveira

Coscueta

et al. 2022

Foods

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A nutrient-rich diet is a key to improving the chemical signals, such as antioxidants, which modulate pathogens’ resistance in the gut and prevent diseases. A current industrial problem is the generation of undervalued by-products, such as tomato bagasse, which are rich in bioactive compounds and of commercial interest (carotenoids and phenolic compounds). This work analyzed the effect of gastrointestinal digestion on the bioactivity and bioaccessibility of carotenoids and phenolic compounds from tomato bagasse extracts. Thus, the extraction by ohmic heating (OH) technology was compared with conventional (organic solvents). The results showed that the main phenolic compounds identified by UPLC-qTOF-MS were p-coumaric acid, naringenin, and luteolin. A higher recovery index for total phenolic compounds throughout the gastrointestinal digestion was observed for OH while for carotenoids, a strong reduction after stomach conditions was observed for both extracts. Furthermore, colon-available fraction exhibited a prebiotic effect upon different Bifidobacterium and Lactobacillus, but a strain-dependent and more accentuated effect on OH. Thus, the extraction technology highly influenced bioaccessibility, with OH demonstrating a positive impact on the recovery of bioactive compounds and related health benefits, such as antioxidant, anti-hypertensive, prebiotic, and anti-inflammatory properties. Of these properties, the last is demonstrated here for the first time.

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Section: Resultsmentioning

confidence: 99%

“…Also, the presence of both extracts had no impact on this bifidobacterial growth comparatively with the positive control (FOS), presenting similar results to the negative control (bacteria growth). As established by some studies, different Bifidobacterium strains may have different carbohydrate utilizing abilities [ 48 , 49 ].…”

Section: Resultsmentioning

confidence: 99%

Bioactivity and Bioaccessibility of Bioactive Compounds in Gastrointestinal Digestion of Tomato Bagasse Extracts

Damasceno

Oliveira

Coscueta

et al. 2022

Foods

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“…Moreover, extracts from Acheta domesticus and Tenebrio molitor were able to inhibit pancreatic lipase (30) , while Pachymerus nucleorum larvae showed tryptic activity together with absence of anti-nutritional factors as well as anti-tryptic and chymotryptic activity (19) . Lastly, flour from Tenebrio molitor affected the growth of Lactobacillus and Bifidobacterium, improving short-chain fatty acid (SCFA) production and viability in nutritive stress conditions (42) .…”

Section: Other Activities In Vitromentioning

confidence: 99%

Functional properties of edible insects: a systematic review

et al. 2021

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Consumption of edible insects has been widely suggested as an environmentally sustainable substitute for meat to reduce GHG emissions. However, the novel research field for edible insects rely on the content of bioactive ingredients and on the ability to induce a functional effect in humans. The goal of this manuscript was to review the available body of evidence on the properties of edible insects in modulating oxidative and inflammatory stress, platelet aggregation, lipid and glucose metabolism and weight control. A search for literature investigating the functional role of edible insects was carried out in the PUBMED database using specific keywords. A total of 55 studies, meeting inclusion criteria after screening, were divided on the basis of the experimental approach: in vitro studies, cellular models/ex vivo studies or in vivo studies. In the majority of the studies, insects demonstrated the ability to reduce oxidative stress, modulate antioxidant status, restore the impaired activity of antioxidant enzymes and reduce markers of oxidative damage. Edible insects displayed anti-inflammatory activity reducing cytokines and modulating specific transcription factors. Results from animal studies suggest that edible insects can modulate lipid and glucose metabolism. The limited number of studies focused on the assessment of anticoagulation activity of edible insects make it difficult to draw conclusions. More evidence from dietary intervention studies in humans is needed to support the promising evidence from in vitro and animal models about the functional role of edible insects consumption.

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“…The bacterial numbers rise from duodenum (10 2 bacteria/g) to colon (10 12 bacteria/g), and the total weight of bacteria can attain ca. 1 kg in an average adult, comprising of up to 5,000 species (de Carvalho et al, 2019). Throughout the digestive tract, the composition and numbers of these communities vary, and every individual has their specie collection, which in turn leads to adjustments over lifetime and is affected by the host lifestyle and nutritional diet (Madureira and Pintado, 2018).…”

Section: Human Gut Microbiotamentioning

confidence: 99%

Intake of nanoparticles and impact on gut microbiota: in vitro and animal models available for testing

Campos

Gómez-García

Oliveira³

2021

Gut. Microb.

Self Cite

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The oral delivery of compounds associated with diet or medication have an impact on the gut microbiota balance, which in turn, influences the physiologic process. Several reports have shown significant advances in clarifying the impact, interactions and outcomes of oral intake of nanoparticles and the human gut. These interactions may affect the bioavailability of the delivered compounds. In addition, there is a considerable breakthrough in the development of antimicrobial nanoparticles for intestinal pathogenic bacteria. Several in vitro fermentation and in vivo models have been developed throughout the years and were used to test these systems. The methodologies and studies carried out so far on the modulation of human and animal gut microbiome by oral delivery nanosized materials were reviewed. Overall, the available in vitro studies mimic the real physiological events enabling to select the best production conditions of nanoparticulate systems in a preliminary stage of research. On the other hand, animal studies can be used to access the dosage effect, safety and correlation between haematological, biochemical and symptoms, with gut microbiota groups and metabolites.

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Potential prebiotic activity of Tenebrio molitor insect flour using an optimized in vitro gut microbiota model

Abstract: Potential prebiotic activity of Tenebrio molitor insect flour using an optimized in vitro gut microbiota model.

Cited by 24 publications

References 35 publications

Bioactivity and Bioaccessibility of Bioactive Compounds in Gastrointestinal Digestion of Tomato Bagasse Extracts

Bioactivity and Bioaccessibility of Bioactive Compounds in Gastrointestinal Digestion of Tomato Bagasse Extracts

Functional properties of edible insects: a systematic review

Intake of nanoparticles and impact on gut microbiota: in vitro and animal models available for testing

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