Potential Predictive Role of Lipid Peroxidation Markers for Type 2 Diabetes in the Adult Tunisian Population

Bouhajja, Houda; Kacem, F. Hadj; Abdelhédi, Rania; Ncir, Marwa; Dimitrov, Jordan D.; Marrakchi, Rim; Jamoussi, Kamel; Rebai, Ahmed; Feki, Abdelfattah El; Abid, M.; Ayadi, Hammadi; Kaveri, Srini V.; Mnif-Feki, Mouna; Bougacha-Elleuch, Noura

doi:10.1016/j.jcjd.2017.06.006

Cited by 14 publications

(10 citation statements)

References 36 publications

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“…To further study whether PCH, FCH, and P-FCH supplementation could alleviate hepatic oxidative stress, the levels of MDA, CGs, and 8-OHdG in liver tissues were measured. MDA is generated from lipid peroxidation and has been suggested as the main indicator of oxidative damage associated with diabetes . CGs and 8-OHdG are biomarkers for protein and DNA oxidative damage, respectively. , In our study, PCH, FCH, and P-FCH treatments significantly reduced hepatic MDA accumulation in diabetic rats ( p < 0.05).…”

Section: Discussionsupporting

confidence: 55%

“…MDA is generated from lipid peroxidation and has been suggested as the main indicator of oxidative damage associated with diabetes. 41 CGs and 8-OHdG are biomarkers for protein and DNA oxidative damage, respectively. 42,43 In our study, PCH, FCH, and P-FCH treatments significantly reduced hepatic MDA accumulation in diabetic rats (p < 0.05).…”

Section: ■ Discussionmentioning

confidence: 99%

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Evaluation and Exploration of Potentially Bioactive Peptides in Casein Hydrolysates against Liver Oxidative Damage in STZ/HFD-Induced Diabetic Rats

Wang

Zheng

et al. 2020

J. Agric. Food Chem.

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Hyperglycemia-induced oxidative stress can cause liver damage in diabetes, and protein hydrolysates with antidiabetic and antioxidant properties are emerging as a potential therapy. In this study, protective effects of casein hydrolysates against live oxidative damage in streptozotocin/high-fat-induced diabetic rats were studied and potentially bioactive peptides were explored by an integrated approach of differential peptide and in silico analysis. Results showed that different casein hydrolysates significantly alleviated liver oxidative damage (p < 0.05) via different mechanisms. Particularly, casein hydrolyzed by a papain–flavourzyme combination (P-FCH) treatment significantly improved liver antioxidant enzyme activities by enhancing nuclear factor erythroid 2-related factor 2 (Nrf2) transcription (p < 0.05). Furthermore, 18 peptides were screened as potential bioactive peptides by analyzing differential peptides among different hydrolysates combined with in silico prediction. Among them, the dipeptide WM might directly inhibit the Kelch-like ECH-associated protein 1 (Keap1)–Nrf2 interaction as potential Nrf2 activators. These results suggested that P-FCH might be an alternative way to treat liver damage in diabetes.

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Section: Discussionsupporting

confidence: 55%

Section: ■ Discussionmentioning

confidence: 99%

Evaluation and Exploration of Potentially Bioactive Peptides in Casein Hydrolysates against Liver Oxidative Damage in STZ/HFD-Induced Diabetic Rats

Wang

Zheng

et al. 2020

J. Agric. Food Chem.

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“…MDA has been confirmed as a lipid peroxidation end product marker. Several investigations have reported elevated MDA levels in diabetes [21,22]. MDA levels of the kidney and liver tissues were found to be higher in STZ-DM groups according to control groups in our study (p<0.001).…”

Section: Discussionsupporting

confidence: 50%

Antidiabetic and antioxidant effects of Lupinus albus L. seed roasting ethanol extract in streptozotocin diabetic rats

Yıldırım¹,

Ertekin²,

Kordalı³

et al. 2020

World J. Adv. Res. Rev.

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Diabetes mellitus (DM) may cause specially health problem which can effect most of tissue such as liver, kidney and brain. Thus, this research aimed to examining the effects of Lupinus albus L. seed ethanol extract (LA) on the liver and renal tissues malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione (GSH) level of diabetic rats. Sprague-Dawley, adult a total of 28 male rats were used in the study that were randomly divided into four groups with 7 animals in each group: Control, STZ-DM, LA and STZ-DM+LA group. Diabetes was induced in rats by a single dose of 60 mg/kg/i.p. Streptozotocin (STZ) injection (STZ-DM and STZ-DM+LA groups). Lupinus albus L. ethanol extract was given at a dose of 10 mg/kg/p.o. via intragastric tube for 20 days (LA and STZ-DM+LA groups). At the end of the study, biochemical and histopathological examination in kidney and liver tissues were examined. STZ application significantly increased the oxidative stress and lipid peroxidation. When the dose of 10 mg/kg of LA significantly decreased the level of plasma glucose and liver and renal MDA. Meanwhile, the levels of liver and renal CAT, SOD, GPx and GSH were significantly increased in diabetic rats treated with Lupinus albus L. seed ethanol extract. These results indicate the role of Lupinus albus L. seed extract might as antidiabetic, antioxidant and reducing of the oxidative stress and lipid peroxidation. Extracted after Lupinus albus seed' roasting is a pioneer in literature and the use of LA in ethnomedicine for diabetes.

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“…Meanwhile, we found that MDA and NO are biomarkers for T2DM disease. MDA is a lipid peroxidation product which is evaluated as an oxidative stress marker and predicts T2DM [29]. NO has a potential role in the pathogenesis of type 2 DM [30].…”

Section: Discussionmentioning

confidence: 99%

Relationship Between Orexin-A and Insulin Resistance in Patients with Type 2 Diabetes Mellitus

Sadiq

Hussein

Maulood

2021

eijs

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Background: Orexin-A is an orexigenic hormone that plays an important role in the metabolism of blood glucose, insulin, and insulin resistance (IR). The pathogenesis of type 2 diabetes mellitus (T2DM) is related to the abnormality in insulin and IR. However, no sufficient studies to date have clearly shown the association of orexin-A with biochemical parameters related to T2DM. Objectives: The aim of this study was to determine the relation of orexin-A with IR and how they associate with physiological changes in T2DM patients. Understanding this relation will offer some pharmacological tools to reduce some complications in diabetes. Materials and Methods: A total of 41 T2DM and 43 non-DM subjects, aged between 40-60 years with body mass index (BMI) ≤25 kg/m2, participated in the present study. Fasting serum orexin-A, IR, fasting blood glucose (FBG), glycated hemoglobin (HbA1C), lipid profile, liver enzymes (alanine aminotransferase (ALT) and aspartate transaminase (AST)), nitric oxide (NO), and malondialdehyde (MDA) parameters were evaluated. Orexin-A was evaluated by using enzyme-linked immunosorbent assay (ELISA). For statistical analysis, GraphPad Prism 7.0 and SPSS version 24.0 programs were used. Results: Orexin-A was positively correlated with blood pressure, FBG, HbA1c, insulin, and IR but inversely related to insulin sensitivity (IS), leptin, and gender. Stepwise multiple regression presented HOMA-IR, diastolic blood pressure, and very-low-density lipoprotein-cholesterol as predictors for orexin-A. The area under control value showed orexin-A, FBG, HbA1c, HOMA-IR, IS, ALT, AST, NO and MDA as biomarkers for T2DM disease. Conclusion: Orexin-A has a predictive ability to diagnose T2DM, as it is significantly associated with hyperglycemia, IR, and IS.

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Potential Predictive Role of Lipid Peroxidation Markers for Type 2 Diabetes in the Adult Tunisian Population

Cited by 14 publications

References 36 publications

Evaluation and Exploration of Potentially Bioactive Peptides in Casein Hydrolysates against Liver Oxidative Damage in STZ/HFD-Induced Diabetic Rats

Evaluation and Exploration of Potentially Bioactive Peptides in Casein Hydrolysates against Liver Oxidative Damage in STZ/HFD-Induced Diabetic Rats

Antidiabetic and antioxidant effects of Lupinus albus L. seed roasting ethanol extract in streptozotocin diabetic rats

Relationship Between Orexin-A and Insulin Resistance in Patients with Type 2 Diabetes Mellitus

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