to investigate the effect of organic (Elkhairat (T) and Elkhasseb (X)) and microbial (Azospirillin (A) and Phosphobacterin (B)) bio-fertilizers and their combinations on S. hermonthica growth and development in Maize.Results showed that all treatments reduced emergence of the parasite, except inoculation with A which enhanced Striga emergence compared to control. Treating maize plants with Striga, irrespective to treatments reduced maize height as compared with free maize. Plants fertilized with T sustained the highest plant growth at 4 weeks after sowing (WAS). It increased maize height by 79% as compared to infested control. At 6 WAS fertilization with X, B+T and A+B+T were significantly increased plant heights as compared to infested control. Leaf number was affected due to Striga infestation. At 6 WAS, all treatments significantly increased leaf numbers except B, A+B and X as compared to infested control. While at 10 WAS, results showed that only A+B+T was significantly increased leaf numbers compared to infested control. Averaged across all fertilization treatments, maize plants infested with Striga had smaller leaf areas than did uninfected plants. At 6 and 10 WAS, X sustained the highest leaf area index compared to all other treatments. Maize treated with X and A+B+T sustained the highest shoot dry weight as compared to infested control . Maize fertilized with X, A+T and A+X showed the highest root dry weight as compared to infested control.