Potential prospect of a therapeutic agent against spring viraemia of carp virus in aquaculture

Qiu, Tian-Xiu; Song, Dawei; Shan, Li-Peng; Liu, Guanglu; Liu, Lei

doi:10.1016/j.aquaculture.2019.734558

Cited by 37 publications

(20 citation statements)

References 36 publications

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“…In this study, WSSV replication in naïve recipient larvae was significantly downregulated after C2 and C7 exposure at each time point ( Figure 7 ). Taken together with the results of earlier studies [ 24 , 33 ], our findings suggest that antiviral coumarins are suitable for static aquaculture systems and for the culture of shrimp seedlings.…”

Section: Resultssupporting

confidence: 86%

“…Moreover, the component complexity and cost-effectivity of these strategies remain limitations of these approaches [ 28 ]. Thus, naturally occurring biological compounds have been isolated and purified from plants or synthesized as potential antiviral agents [ 19 , 21 , 24 , 31 , 32 , 33 ]. For example, epigallocatechin gallate is a promising therapeutic agent against grass carp reovirus (GCRV) infection by blocking its binding to laminin receptors [ 34 ]; saikosaponin D efficiently suppressed spring viremia of carp virus (SVCV) replication in vivo, prolonging the survival of zebrafish and common carp [ 35 ].…”

Section: Resultsmentioning

confidence: 99%

“…Earlier synthetic coumarins with a variety of pharmacophoric groups at the C-3, C-4, and C-7 positions have been screened intensively for antiviral effects, based on the correlation between structural characteristics and biological activities [ 21 ]. In addition to its application in human viral diseases, it has the advantages of being stable, soluble, and of low molecular weight, without any adverse side effects and toxicity, making coumarin derivatives candidate drugs for use against aquatic viruses [ 18 , 19 , 22 , 23 , 24 ], including WSSV.…”

Section: Introductionmentioning

confidence: 99%

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Small Molecule Inhibitors of White Spot Syndrome Virus: Promise in Shrimp Seedling Culture

Liu

Shan

Zhou

et al. 2021

IJMS

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Rapid production of prawn (Litopenaeus vannamei) under artificial pressure can result in a series of obvious challenges and is vulnerable to serious losses related to aquatic environmental issues and the unrestrained outbreak of white spot syndrome (WSS). However, to date, there are no therapeutic strategies to contain the spread of the virus. Here, we synthesized 27 coumarin deriv-atives and evaluated their anti-white spot syndrome virus (WSSV) activity in L. vannamei larvae. We demonstrated that electron-withdrawing and electron-giving substituent groups play an im-portant role in reducing toxicity and WSSV replication, respectively. Two coumarin C2 (2-amino-5-oxo-4-(p-tolyl)-4H,5H-pyrano[3,2-c]chromene-3-carbonitrile) and C7 (2-amino-4-(4-chlorophenyl)-5-oxo-4H,5H-pyrano[3,2-c]chromene-3-carbonitrile) were regarded as the most promising anti-WSSV compounds with maximum antiviral response <5% and median effective concentration <10 mg/L. The mortality of WSSV-infected larvae decreased by more than 60% after exposure to C2 and C7. With continuous immersion of C2 and C7 exchange, the mortality further decreased to 40% at 120 h.Additionally, C2 and C7 are the relatively stable in aquacultural water, making these agents

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Section: Resultssupporting

confidence: 86%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Small Molecule Inhibitors of White Spot Syndrome Virus: Promise in Shrimp Seedling Culture

Liu

Shan

Zhou

et al. 2021

IJMS

Self Cite

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“…C2 and B4 were also tested in vivo; C2 injected i.p. into zebrafish reduced the horizontal transmission of SVCV (Liu et al 2019a), and B4 enhanced the survival rate of zebrafish and common carp through both bath and injection treatments and reduced the horizontal transmission of SVCV (Qiu et al 2020). Another coumarin derivative, D5, was found to have an impact on SVCV glycoprotein structure, disrupting binding to EPC cells and inhibiting viral translocation into the cytosol, but D5 also inhibited SVCV-induced autophagy, which is needed for SVCV replication (Chen et al 2018a).…”

Section: Implementation Of Natural Compounds As Antiviralsmentioning

confidence: 99%

“…2017, 2018b; 2019a, 2019b, 2020a, 2020b; Qiu et al . 2020). Numerous coumarin derivatives were first tested in vitro , and then, the two compounds with the highest antiviral activity in EPC cells were selected: coumarins termed B4 and C2 (Liu et al .…”

Section: Implementation Of Natural Compounds As Antiviralsmentioning

confidence: 99%

Compilation of antiviral treatments and strategies to fight fish viruses

Pereiro

Figueras

Novoa

2020

Reviews in Aquaculture

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The implementation of antiviral treatments and prophylaxis strategies in fish aquaculture needs to be established. The absence of commercial vaccines for most viral diseases affecting economically relevant fish species, and the total lack of treatments to fight these diseases once they have emerged in a fish farm remains one of the main bottlenecks in fish aquaculture production. However, although no antivirals are currently applied on farms, a great number of investigations have been conducted to assess the potential use of antiviral treatments against several fish viruses. Although most of these works were based on in vitro approaches, some included in vivo experiments to demonstrate the potential applicability of these treatments. This review summarizes the investigations conducted both in vitro and in vivo in the field of antiviral treatments against fish viruses. The highlighted works include those using piscine and non-piscine proteins with antimicrobial functions, metabolites, chemical compounds (some of which are used in medicine to treat human viruses), bioactive compounds mainly isolated from plants and bacteria, and emerging DNA-and RNA-based therapeutics. This information can be used for developing both specific and broad-spectrum antiviral strategies to be further used in the aquaculture industry, and it may even provide interesting indications for biomedical research.

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Evaluation of the Differential Postbiotic Potential of Shewanella putrefaciens Pdp11 Cultured in Several Growing Conditions

Domínguez-Maqueda,

García-Márquez,

Tapia-Paniagua

et al. 2023

Mar Biotechnol

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The increased knowledge of functional foods has led to the development of a new generation of health products, including those containing probiotics and products derived from them. Shewanella putrefaciens Pdp11 (SpPdp11) is a strain described as a probiotic that exerts important beneficial effects on several farmed fish. However, the use of live probiotic cells in aquaculture has limitations such as uncertain survival and shelf life, which can limit their efficacy. In addition, its efficacy can vary across species and hosts. When probiotics are administered orally, their activity can be affected by the environment present in the host and by interactions with the intestinal microbiota. Furthermore, live cells can also produce undesired substances that may negatively impact the host as well as the risk of potential virulence reversion acquired such as antibiotic resistance. Therefore, new alternatives emerged such as postbiotics. Currently, there is no knowledge about the postbiotic potential of SpPdp11 in the aquaculture industry. Postbiotic refers to the use of bacterial metabolites, including extracellular products (ECPs), to improve host physiology. However, the production of postbiotic metabolites can be affected by various factors such as cultivation conditions, which can affect bacterial metabolism. Thus, the objective of this study was to evaluate the postbiotic potential of ECPs from SpPdp11 under different cultivation conditions, including culture media, temperature, growth phase, and salinity. We analyzed their hydrolytic, antibacterial, antiviral, and cytotoxic capacity on several fish cell lines. The results obtained have demonstrated how each ECP condition can exert a different hydrolytic profile, reduce the biofilm formation by bacterial pathogens relevant to fish, lower the titer of nervous necrosis virus (NNV), and exert a cytotoxic effect on different fish cell lines. In conclusion, the ECPs obtained from SpPdp11 have different capacities depending on the cultivation conditions used. These conditions must be considered in order to recover the maximum number of beneficial capacities or to choose the appropriate conditions for specific activities.

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Potential prospect of a therapeutic agent against spring viraemia of carp virus in aquaculture

Cited by 37 publications

References 36 publications

Small Molecule Inhibitors of White Spot Syndrome Virus: Promise in Shrimp Seedling Culture

Small Molecule Inhibitors of White Spot Syndrome Virus: Promise in Shrimp Seedling Culture

Compilation of antiviral treatments and strategies to fight fish viruses

Evaluation of the Differential Postbiotic Potential of Shewanella putrefaciens Pdp11 Cultured in Several Growing Conditions

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